Department Directory

  • Richard Clinton Becker, MD
  • Professor of Medicine
  • Academic Office:
    University of Cincinnati College of Medicine
    231 Albert Sabin Way
    Cincinnati, OH 45267
  • Phone: 513.558.1067
  • Email: richard.becker@uc.edu

    Research/Clinical Interests:

  • My research focuses on platelets, coagulation proteins, nucleic acids, cell-free DNA-histone complexes and oligonucleotides as reversable antithrombotic agents.

    Education/Credentials:

  • MD: University of Cincinnati College of Medicine, 1982

Board Certifications & Licenses:

  • Internal Medicine
  • Cardiovascular Disease

Peer Reviewed Publications (in chronological order):

  • Voora, D., Cyr, D., Lucas, J., Chi, J., Dungan, J., McCaffrey, T. A., Katz, R., Newby, L. K., Kraus, W. E., Becker, R. C., Ortel, T. L., & Ginsburg, G. S. (2013). Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. . Journal of the American College of Cardiology , 62 (14) , 1267-76.
  • Åkerblom, A., Wallentin, L., Larsson, A., Siegbahn, A., Becker, R. C., Budaj, A., Himmelmann, A., Horrow, J., Husted, S., Storey, R. F., Asenblad, N., & James, S. K. (2013). Cystatin C- and creatinine-based estimates of renal function and their value for risk prediction in patients with acute coronary syndrome: results from the PLATelet Inhibition and Patient Outcomes (PLATO) study. . Clinical Chemistry , 59 (9) , 1369-75.
  • Jackson, L. R., & Becker, R. C. (2013). Novel oral anticoagulants: pharmacology, coagulation measures, and considerations for reversal. . Journal of Thrombosis and Thrombolysis.
  • Povsic, T. J., Vavalle, J. P., Aberle, L. H., Kasprzak, J. D., Cohen, M. G., Mehran, R., Bode, C., Buller, C. E., Montalescot, G., Cornel, J. H., Rynkiewicz, A., Ring, M. E., Zeymer, U., Natarajan, M., Delarche, N., Zelenkofske, S. L., Becker, R. C., & Alexander, J. H. (2013). A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial. . European Heart Journal , 34 (31) , 2481-9.
  • James, S. K., Storey, R. F., Pieper, K. S., Cannon, C. P., Becker, R. C., Steg, P. G., Wallentin, L., & Harrington, R. A. (2013). Response to letter regarding article, "Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials". . Stroke; A Journal of Cerebral Circulation , 44 (8) , e95-6.
  • Mentz, R. J., & Becker, R. C. (2013). Funding opportunities for clinical investigators in the early stages of career development in cardiovascular research. . Journal of Thrombosis and Thrombolysis.
  • Dewald, T. A., & Becker, R. C. (2013). The pharmacology of novel oral anticoagulants. . Journal of Thrombosis and Thrombolysis.
  • Mahaffey, K. W., Wojdyla, D., Hankey, G. J., White, H. D., Nessel, C. C., Piccini, J. P., Patel, M. R., Berkowitz, S. D., Becker, R. C., Halperin, J. L., Singer, D. E., Califf, R. M., Fox, K. A. A., Breithardt, G., & Hacke, W. (2013). Clinical outcomes with rivaroxaban in patients transitioned from vitamin K antagonist therapy: a subgroup analysis of a randomized trial. . Annals of Internal Medicine , 158 (12) , 861-8.
  • Rodés-Cabau, J., Dauerman, H. L., Cohen, M. G., Mehran, R., Small, E. M., Smyth, S. S., Costa, M. A., Mega, J. L., O'Donoghue, M. L., Ohman, E. M., & Becker, R. C. (2013). Antithrombotic Treatment in Transcatheter Aortic Valve Implantation: Insights for Cerebrovascular and Bleeding Events. . Journal of the American College of Cardiology.
  • Singer, D. E., Hellkamp, A. S., Piccini, J. P., Mahaffey, K. W., Lokhnygina, Y., Pan, G., Halperin, J. L., Becker, R. C., Breithardt, G., Hankey, G. J., Hacke, W., Nessel, C. C., Patel, M. R., Califf, R. M., & Fox, K. A. A. (2013). Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial. . Journal of the American Heart Association , 2 (1) , e000067.
  • Patel, M. R., Hellkamp, A. S., Lokhnygina, Y., Piccini, J. P., Zhang, Z., Mohanty, S., Singer, D. E., Hacke, W., Breithardt, G., Halperin, J. L., Hankey, G. J., Becker, R. C., Nessel, C. C., Berkowitz, S. D., Califf, R. M., Fox, K. A. A., & Mahaffey, K. W. (2013). Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation). . Journal of the American College of Cardiology , 61 (6) , 651-8.
  • Becker, Richard C (2013). A thought experiment in contemporary drug development: informed bench-to-bedside strategies. . Journal of the American Heart Association , 2 (1) , e000031.
  • Bernacki, G. M., & Becker, R. C. (2013). Oral anticoagulants in older adults with atrial fibrillation. . Journal of Thrombosis and Thrombolysis.
  • Piccini, J. P., Stevens, S. R., Chang, Y., Singer, D. E., Lokhnygina, Y., Go, A. S., Patel, M. R., Mahaffey, K. W., Halperin, J. L., Breithardt, G., Hankey, G. J., Hacke, W., Becker, R. C., Nessel, C. C., Fox, K. A. A., & Califf, R. M. (2013). Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts. . Circulation , 127 (2) , 224-32.
  • Krishnan, A., Vogler, E. A., Sullenger, B. A., & Becker, R. C. (2013). The effect of surface contact activation and temperature on plasma coagulation with an RNA aptamer directed against factor IXa. . Journal of Thrombosis and Thrombolysis , 35 (1) , 48-56.
  • Berger, J. S., Becker, R. C., Kuhn, C., Helms, M. J., Ortel, T. L., & Williams, R. (2013). Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation. . Thrombosis and Haemostasis , 109 (1) , 85-92.
  • Chan, M. Y., Lin, M., Lucas, J., Moseley, A., Thompson, J. W., Cyr, D., Ueda, H., Kajikawa, M., Ortel, T. L., & Becker, R. C. (2012). Plasma proteomics of patients with non-valvular atrial fibrillation on chronic anti-coagulation with warfarin or a direct factor Xa inhibitor. . Thrombosis and Haemostasis , 108 (6) , 1180-91.
  • Husted, S., James, S., Becker, R. C., Horrow, J., Katus, H., Storey, R. F., Cannon, C. P., Heras, M., Lopes, R. D., Morais, J., Mahaffey, K. W., Bach, R. G., Wojdyla, D., & Wallentin, L. (2012). Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial. . Circulation. Cardiovascular Quality and Outcomes , 5 (5) , 680-8.
  • Angiolillo, D. J., Schneider, D. J., Bhatt, D. L., French, W. J., Price, M. J., Saucedo, J. F., Shaburishvili, T., Huber, K., Prats, J., Liu, T., Harrington, R. A., & Becker, R. C. (2012). Pharmacodynamic effects of cangrelor and clopidogrel: the platelet function substudy from the cangrelor versus standard therapy to achieve optimal management of platelet inhibition (CHAMPION) trials. . Journal of Thrombosis and Thrombolysis , 34 (1) , 44-55.
  • Wisler, J. W., & Becker, R. C. (2012). A guidance pathway for the selection of novel anticoagulants in the treatment of atrial fibrillation. . Critical Pathways in Cardiology , 11 (2) , 55-61.
  • Rowley, J. W., Finn, A. V., French, P. A., Jennings, L. K., Bluestein, D., Gross, P. L., Freedman, J. E., Steinhubl, S. R., Zimmerman, G. A., Becker, R. C., Dauerman, H. L., & Smyth, S. S. (2012). Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. . Circulation. Cardiovascular Interventions , 5 (2) , 296-304.
  • Wisler, J. W., Washam, J. B., & Becker, R. C. (2012). Evaluation of dose requirements for prolonged bivalirudin administration in patients with renal insufficiency and suspected heparin-induced thrombocytopenia. . Journal of Thrombosis and Thrombolysis , 33 (3) , 287-95.
  • Hankey, G. J., Patel, M. R., Stevens, S. R., Becker, R. C., Breithardt, G., Carolei, A., Diener, H., Donnan, G. A., Halperin, J. L., Mahaffey, K. W., Mas, J., Massaro, A., Norrving, B., Nessel, C. C., Paolini, J. F., Roine, R. O., Singer, D. E., Wong, L., Califf, R. M., Fox, K. A. A., & Hacke, W. (2012). Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. . Lancet Neurology , 11 (4) , 315-22.
  • Chan, M. Y., Tan, K., Tan, H., Huan, P., Li, B., Phua, Q., Lee, H., Lee, C., Low, A., Becker, R. C., Ong, W., Richards, M. A., Salim, A., Tai, E., & Koay, E. (2012). CYP2C19 and PON1 polymorphisms regulating clopidogrel bioactivation in Chinese, Malay and Indian subjects. . Pharmacogenomics , 13 (5) , 533-42.
  • Wisler, J. W., & Becker, R. C. (2012). Oral factor Xa inhibitors for the long-term management of ACS. . Nature Reviews. Cardiology , 9 (7) , 392-401.
  • Nimjee, S. M., Lohrmann, J. D., Wang, H., Snyder, D. J., Cummings, T. J., Becker, R. C., Oney, S., & Sullenger, B. A. (2012). Rapidly regulating platelet activity in vivo with an antidote controlled platelet inhibitor. . Molecular Therapy : the Journal of the American Society of Gene Therapy , 20 (2) , 391-7.
  • Akerblom, Å., Wallentin, L., Siegbahn, A., Becker, R. C., Budaj, A., Buck, K., Giannitsis, E., Horrow, J., Husted, S., Katus, H. A., Steg, P. G., Storey, R. F., Åsenblad, N., & James, S. K. (2012). Cystatin C and estimated glomerular filtration rate as predictors for adverse outcome in patients with ST-elevation and non-ST-elevation acute coronary syndromes: results from the Platelet Inhibition and Patient Outcomes study. . Clinical Chemistry , 58 (1) , 190-9.
  • Storey, R. F., Becker, R. C., Harrington, R. A., Husted, S., James, S. K., Cools, F., Steg, P. G., Khurmi, N. S., Emanuelsson, H., Lim, S. T., Cannon, C. P., Katus, H. A., & Wallentin, L. (2011). Pulmonary function in patients with acute coronary syndrome treated with ticagrelor or clopidogrel (from the Platelet Inhibition and Patient Outcomes [PLATO] pulmonary function substudy). . The American Journal of Cardiology , 108 (11) , 1542-6.
  • Storey, R. F., Becker, R. C., Harrington, R. A., Husted, S., James, S. K., Cools, F., Steg, P. G., Khurmi, N. S., Emanuelsson, H., Cooper, A., Cairns, R., Cannon, C. P., & Wallentin, L. (2011). Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes. . European Heart Journal , 32 (23) , 2945-53.
  • Fox, K. A. A., Piccini, J. P., Wojdyla, D., Becker, R. C., Halperin, J. L., Nessel, C. C., Paolini, J. F., Hankey, G. J., Mahaffey, K. W., Patel, M. R., Singer, D. E., & Califf, R. M. (2011). Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment. . European Heart Journal , 32 (19) , 2387-94.
  • Povsic, T. J., Wargin, W. A., Alexander, J. H., Krasnow, J., Krolick, M., Cohen, M. G., Mehran, R., Buller, C. E., Bode, C., Zelenkofske, S. L., Rusconi, C. P., & Becker, R. C. (2011). Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy. . European Heart Journal , 32 (19) , 2412-9.
  • Faxon, D. P., Eikelboom, J. W., Berger, P. B., Holmes, D. R., Bhatt, D. L., Moliterno, D. J., Becker, R. C., & Angiolillo, D. J. (2011). Consensus document: antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting. A North-American perspective. . Thrombosis and Haemostasis , 106 (4) , 572-84.
  • Ahmad, T., Voora, D., & Becker, R. C. (2011). The pharmacogenetics of antiplatelet agents: towards personalized therapy? . Nature Reviews. Cardiology , 8 (10) , 560-71.
  • Lopes, R. D., Becker, R. C., Alexander, J. H., Armstrong, P. W., Califf, R. M., Chan, M. Y., Crowther, M., Granger, C. B., Harrington, R. A., Hylek, E. M., James, S. K., Jolicoeur, E. M., Mahaffey, K. W., Newby, L. K., Peterson, E. D., Pieper, K. S., Van de Werf, F., Wallentin, L., White, H. D., Carvalho, A. C., Giraldez, R. R., Guimaraes, H. P., Nader, H. B., Kalil, R. A. K., Bizzachi, J. M. A., Lopes, A. C., & Garcia, D. A. (2011). Highlights from the III International Symposium of Thrombosis and Anticoagulation (ISTA), October 14-16, 2010, São Paulo, Brazil. . Journal of Thrombosis and Thrombolysis , 32 (2) , 242-66.
  • Woodruff, R. S., Sullenger, B., & Becker, R. C. (2011). The many faces of the contact pathway and their role in thrombosis. . Journal of Thrombosis and Thrombolysis , 32 (1) , 9-20.
  • Becker, Richard C (2011). Early-onset obesity and the unwanted promise of thrombosis. . Journal of Thrombosis and Thrombolysis , 32 (1) , 125-8.
  • Held, C., Asenblad, N., Bassand, J. P., Becker, R. C., Cannon, C. P., Claeys, M. J., Harrington, R. A., Horrow, J., Husted, S., James, S. K., Mahaffey, K. W., Nicolau, J. C., Scirica, B. M., Storey, R. F., Vintila, M., Ycas, J., & Wallentin, L. (2011). Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. . Journal of the American College of Cardiology , 57 (6) , 672-84.
  • Povsic, T. J., Cohen, M. G., Mehran, R., Buller, C. E., Bode, C., Cornel, J. H., Kasprzak, J. D., Montalescot, G., Joseph, D., Wargin, W. A., Rusconi, C. P., Zelenkofske, S. L., Becker, R. C., & Alexander, J. H. (2011). A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial. . American Heart Journal , 161 (2) , 261-268.e1-2.
  • Williams, M. S., Weiss, E. J., Sabatine, M. S., Simon, D. I., Bahou, W. F., Becker, L. C., Parise, L. V., Dauerman, H. L., French, P. A., Smyth, S. S., & Becker, R. C. (2010). Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. . Arteriosclerosis, Thrombosis, and Vascular Biology , 30 (12) , 2372-84.
  • Povsic, T. J., Sullenger, B. A., Zelenkofske, S. L., Rusconi, C. P., & Becker, R. C. (2010). Translating nucleic acid aptamers to antithrombotic drugs in cardiovascular medicine. . Journal of Cardiovascular Translational Research , 3 (6) , 704-16.
  • Steg, P. G., James, S., Harrington, R. A., Ardissino, D., Becker, R. C., Cannon, C. P., Emanuelsson, H., Finkelstein, A., Husted, S., Katus, H., Kilhamn, J., Olofsson, S., Storey, R. F., Weaver, W. D., & Wallentin, L. (2010). Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. . Circulation , 122 (21) , 2131-41.
  • Wallentin, L., James, S., Storey, R. F., Armstrong, M., Barratt, B. J., Horrow, J., Husted, S., Katus, H., Steg, P. G., Shah, S. H., & Becker, R. C. (2010). Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. . Lancet , 376 (9749) , 1320-8.
  • Cohen, M. G., Purdy, D. A., Rossi, J. S., Grinfeld, L. R., Myles, S. K., Aberle, L. H., Greenbaum, A. B., Fry, E., Chan, M. Y., Tonkens, R. M., Zelenkofske, S., Alexander, J. H., Harrington, R. A., Rusconi, C. P., & Becker, R. C. (2010). First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention. . Circulation , 122 (6) , 614-22.
  • Woodruff, B., Sullenger, B., & Becker, R. C. (2010). Antithrombotic therapy in acute coronary syndrome: how far up the coagulation cascade will we go? . Current Cardiology Reports , 12 (4) , 315-20.
  • Lopes, R. D., Garcia, D., Becker, R. C., Granger, C. B., Newby, L. K., Alexander, J. H., Jolicoeur, E. M., Handler, A., Pieper, K. S., Carvalho, A. C., Guimaraes, H. P., Chamone, D. A. F., Baruzzi, A. C., Machado, F. S., Timerman, A., & Lopes, A. C. (2010). Highlights from the II International Symposium of Thrombosis and Anticoagulation (ISTA), October 22-23, 2009, São Paulo, Brazil. . Journal of Thrombosis and Thrombolysis , 29 (4) , 395-408.
  • Brummett, B. H., Boyle, S. H., Ortel, T. L., Becker, R. C., Siegler, I. C., & Williams, R. B. (2010). Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall. . Psychosomatic Medicine , 72 (4) , 333-9.
  • Rao, S. V., Melloni, C., Myles-Dimauro, S., Broderick, S., Kosinski, A. S., Kleiman, N. S., Dzavík, V., Tanguay, J. F., Chandna, H., Gammon, R., Rivera, E., Alexander, J. H., Fier, I., Roach, J., & Becker, R. C. (2010). Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial. . Circulation , 121 (15) , 1713-21.
  • Krishnan, A., Lopes, R. D., Alexander, J. H., Becker, R. C., & Goldstein, L. B. (2010). Antithrombotic therapy for ischemic stroke: guidelines translated for the clinician. . Journal of Thrombosis and Thrombolysis , 29 (3) , 368-77.
  • Chan, M. Y., Becker, R. C., Sim, L., Tan, V., Lee, C., Low, A. F. H., Teo, S., Ng, K., Tan, H., & Yeo, T. (2010). Reperfusion strategy and mortality in ST-elevation myocardial infarction among patients with and without impaired renal function. . Annals of the Academy of Medicine, Singapore , 39 (3) , 179-84.
  • Mackman, N., & Becker, R. C. (2010). DVT: a new era in anticoagulant therapy. . Arteriosclerosis, Thrombosis, and Vascular Biology , 30 (3) , 369-71.
  • Becker, R. C., & Gurbel, P. A. (2010). Platelet P2Y12 receptor antagonist pharmacokinetics and pharmacodynamics: A foundation for distinguishing mechanisms of bleeding and anticipated risk for platelet-directed therapies. . Thrombosis and Haemostasis , 103 (3) , 535-44.
  • Katz, J. N., Shah, B. R., Volz, E. M., Horton, J. R., Shaw, L. K., Newby, L. K., Granger, C. B., Mark, D. B., Califf, R. M., & Becker, R. C. (2010). Evolution of the coronary care unit: clinical characteristics and temporal trends in healthcare delivery and outcomes. . Critical Care Medicine , 38 (2) , 375-81.
  • Cannon, C. P., Harrington, R. A., James, S., Ardissino, D., Becker, R. C., Emanuelsson, H., Husted, S., Katus, H., Keltai, M., Khurmi, N. S., Kontny, F., Lewis, B. S., Steg, P. G., Storey, R. F., Wojdyla, D., & Wallentin, L. (2010). Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. . Lancet , 375 (9711) , 283-93.
  • Kiefer, T. L., & Becker, R. C. (2009). Inhibitors of platelet adhesion. . Circulation , 120 (24) , 2488-95.
  • Becker, R. C., Scheiman, J., Dauerman, H. L., Spencer, F., Rao, S., Sabatine, M., Johnson, D. A., Chan, F., Abraham, N. S., & Quigley, E. M. M. (2009). Management of platelet-directed pharmacotherapy in patients with atherosclerotic coronary artery disease undergoing elective endoscopic gastrointestinal procedures. . The American Journal of Gastroenterology , 104 (12) , 2903-17.
  • Becker, R. C., & Chan, M. Y. (2009). REG-1, a regimen comprising RB-006, a Factor IXa antagonist, and its oligonucleotide active control agent RB-007 for the potential treatment of arterial thrombosis. . Current Opinion in Molecular Therapeutics , 11 (6) , 707-15.
  • Smyth, S. S., McEver, R. P., Weyrich, A. S., Morrell, C. N., Hoffman, M. R., Arepally, G. M., French, P. A., Dauerman, H. L., & Becker, R. C. (2009). Platelet functions beyond hemostasis. . Journal of Thrombosis and Haemostasis : JTH , 7 (11) , 1759-66.
  • Chan, M. Y., Weitz, J. I., Merhi, Y., Harrington, R. A., & Becker, R. C. (2009). Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs. . Journal of Thrombosis and Thrombolysis , 28 (3) , 366-80.
  • Wallentin, L., Becker, R. C., Budaj, A., Cannon, C. P., Emanuelsson, H., Held, C., Horrow, J., Husted, S., James, S., Katus, H., Mahaffey, K. W., Scirica, B. M., Skene, A., Steg, P. G., Storey, R. F., Harrington, R. A., Freij, A., & Thorsén, M. (2009). Ticagrelor versus clopidogrel in patients with acute coronary syndromes. . The New England Journal of Medicine , 361 (11) , 1045-57.
  • Berger, J. S., Elliott, L., Gallup, D., Roe, M., Granger, C. B., Armstrong, P. W., Simes, R. J., White, H. D., Van de Werf, F., Topol, E. J., Hochman, J. S., Newby, L. K., Harrington, R. A., Califf, R. M., Becker, R. C., & Douglas, P. S. (2009). Sex differences in mortality following acute coronary syndromes. . JAMA : the Journal of the American Medical Association , 302 (8) , 874-82.
  • Smyth, S. S., Woulfe, D. S., Weitz, J. I., Gachet, C., Conley, P. B., Goodman, S. G., Roe, M. T., Kuliopulos, A., Moliterno, D. J., French, P. A., Steinhubl, S. R., & Becker, R. C. (2009). G-protein-coupled receptors as signaling targets for antiplatelet therapy. . Arteriosclerosis, Thrombosis, and Vascular Biology , 29 (4) , 449-57.
  • Berger, J. S., Frye, C. B., Harshaw, Q., Edwards, F. H., Steinhubl, S. R., & Becker, R. C. (2008). Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis. . Journal of the American College of Cardiology , 52 (21) , 1693-701.
  • Becker, R. C., & Sane, D. (2008). Early career investigator's circle: identifying and nurturing the next generation of scientists and scientific writers. . Journal of Thrombosis and Thrombolysis , 26 (2) , 165.
  • Lohrmann, J., & Becker, R. C. (2008). New anticoagulants--the path from discovery to clinical practice. . The New England Journal of Medicine , 358 (26) , 2827-9.
  • Douketis, J. D., Berger, P. B., Dunn, A. S., Jaffer, A. K., Spyropoulos, A. C., Becker, R. C., & Ansell, J. (2008). The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). . Chest , 133 (6 Suppl) , 299S-339S.
  • Chan, M. Y., Becker, R. C., Harrington, R. A., Peterson, E. D., Armstrong, P. W., White, H., Fox, K. A. A., Ohman, E. M., & Roe, M. T. (2008). Noninvasive, medical management for non-ST-elevation acute coronary syndromes. . American Heart Journal , 155 (3) , 397-407.
  • Gurbel, P. A., Becker, R. C., Mann, K. G., Steinhubl, S. R., & Michelson, A. D. (2007). Platelet function monitoring in patients with coronary artery disease. . Journal of the American College of Cardiology , 50 (19) , 1822-34.
  • Becker, Richard C (2007). Off-target properties of pharmacotherapy and the importance of mechanistic investigations in early clinical phase drug development. . Journal of Thrombosis and Thrombolysis , 23 (2) , 159-61.
  • Katz, J. N., Turer, A. T., & Becker, R. C. (2007). Cardiology and the critical care crisis: a perspective. . Journal of the American College of Cardiology , 49 (12) , 1279-82.
  • Dyke, C. K., Steinhubl, S. R., Kleiman, N. S., Cannon, R. O., Aberle, L. G., Lin, M., Myles, S. K., Melloni, C., Harrington, R. A., Alexander, J. H., Becker, R. C., & Rusconi, C. P. (2006). First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity. . Circulation , 114 (23) , 2490-7.
  • Patel, M. R., Meine, T. J., Lindblad, L., Griffin, J., Granger, C. B., Becker, R. C., Van de Werf, F., White, H., Califf, R. M., & Harrington, R. A. (2006). Cardiac tamponade in the fibrinolytic era: analysis of >100,000 patients with ST-segment elevation myocardial infarction. . American Heart Journal , 151 (2) , 316-22.
  • Krishnan, R., Becker, R. J., Beighley, L. M., & López-Candales, A. (2005). Impact of body mass index on markers of left ventricular thickness and mass calculation: results of a pilot analysis. . Echocardiography (Mount Kisco, N.Y.) , 22 (3) , 203-10.
  • Becker, R. C., Alexander, J. H., Li, Y., Robertson, T., Kunitada, S., Spencer, F. A., Yang, H., & Harrington, R. A. (2004). Vascular endothelial tissue factor pathway inhibitor kinetics in culture following exposure to DX-9065a--a selective and direct factor Xa inhibitor. . Journal of Thrombosis and Thrombolysis , 18 (3) , 193-7.
  • Dyke, C. K., Becker, R. C., Kleiman, N. S., Hochman, J. S., Bovill, E. G., Lincoff, A. M., Gerstenblith, G., Dzavik, V., Gardner, L. H., Hasselblad, V., Zillman, L. A., Shimoto, Y., Robertson, T. L., Kunitada, S., Armstrong, P. W., & Harrington, R. A. (2002). First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation. . Circulation , 105 (20) , 2385-91.

    Research Grants:

  • U01HL0807229NHLBI. BRIDGE Trial Determine the safety and efficacy of bridging anticoagulant therapy in patients with atrial fibrillation who require cessation of an oral anticoagulant for surgery or invasive procedure, Co-PI
  • R01-HL065222NHLBI. Antithrombotic Aptamers and Antidotes Develop and test coagulation protein and platelet directed aptamers and their complementary antidotes - Grant, Co-investigator, Active.
  • P01-HL036587NIH. genetic and Environmental influences on the expression of CVD endophenotypes Identify genetic variants that interact with environmental and psycho-social conditions and increase cardiovascular risk. Study the effects of mental stress on platelet biology., Project PI
  • U54-HL112307NHLBI. Translational Research centers for Thrombotic and hemostatic Disorders Translate a von Willebrand factor aptamer and antidote to first in human studies, PI
  • U54-HL112307NHLBI. TRC-THD Administrative Coordinating Center Serve as ACC for U54 grant that includes 5 sites studying translational platforms for thrombotic and hemostatic disorders. - Grant, PI, Active.
  • 2033678 / P01 HL036587 National Heart, Lung and Blood Institute. Genes, Environmental Stressors and the Biobehavioral Pathways to CHD, PI, Awarded.
CARE/Crawley Building

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Email: ucintmed@uc.edu