Department Directory

  • Jason Blackard, PhD
  • Associate Professor of Medicine
    (Digestive Diseases); Director, Office of Global Health
  • Academic Office:
    Office 7210 Medical Sciences Building
    231 Albert Sabin Way
    Cincinnati, OH 45267-0595
  • Phone: (513)558-4389
  • Email: jason.blackard@uc.edu

    Research/Clinical Interests:

  • Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV) Co-infection on Liver Fibrosis, HCV RNA levels, HCV Disease Progression and Response Rates to HCV treatment, Cell Culture, Immunologic and Molecular Virology Techniques, Hepatitis B (HBV), Hepatitis E (HEV) and Hepatitis G (HGV/GBV-C).

    Education/Credentials:

  • Bachelor's Degree: University of Arkansas, 1994
  • Doctoral Degree: Harvard University, 2000
  • Fellowship: Gastrointestinal Unit Harvard Medical School/Massachusetts General Hospital , 2005

Peer Reviewed Publications (in chronological order):

  • Gededzha, M. P., Selabe, S. G., Blackard, J. T., Kyaw, T., & Mphahlele, M. J. (2013). Near full-length genome analysis of HCV genotype 5 strains from South Africa. . Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases , 21C , 118-123.
  • Penton, P. K., & Blackard, J. T. (2013). Analysis of HIV Quasispecies Suggests Compartmentalization in the Liver. . AIDS Research and Human Retroviruses.
  • Blackard, J. T., Kong, L., Huber, A. K., & Tomer, Y. (2013). Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of hepatitis C virus and thyroiditis. . Thyroid : Official Journal of the American Thyroid Association , 23 (7) , 863-70.
  • Sengupta, S., Powell, E., Kong, L., & Blackard, J. T. (2013). Effects of HCV on basal and tat-induced HIV LTR activation. . PloS One , 8 (6) , e64956.
  • Blackard, J. T., Martin, C. M., Sengupta, S., & Forrester, J. (2013). Limited infection with occult hepatitis B virus in drug users in the USA. . Hepatology Research : the Official Journal of the Japan Society of Hepatology , 43 (4) , 413-7.
  • Mayaphi, S. H., Martin, D. J., Mphahlele, M. J., Blackard, J. T., & Bowyer, S. M. (2013). Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV. . Journal of Medical Virology , 85 (11) , 1883-92.
  • Kong, L., & Blackard, J. T. (2013). Interferon alfa partially inhibits HIV replication in hepatocytes in vitro. . The Journal of Infectious Diseases , 208 (5) , 865-6.
  • Martin, C. M., Welge, J. A., Rouster, S. D., Shata, M. T., Sherman, K. E., & Blackard, J. T. (2012). Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro. . Journal of Viral Hepatitis , 19 (10) , 716-23.
  • Kong, L., Cardona Maya, W., Moreno-Fernandez, M. E., Ma, G., Shata, M. T., Sherman, K. E., Chougnet, C., & Blackard, J. T. (2012). Low-level HIV infection of hepatocytes. . Virology Journal , 9 , 157.
  • Blackard, Jason T (2012). HIV compartmentalization: a review on a clinically important phenomenon. . Current HIV Research , 10 (2) , 133-42.
  • Blackard, J. T., Ma, G., Welge, J. A., Martin, C. M., Sherman, K. E., Taylor, L. E., Mayer, K. H., & Jamieson, D. J. (2012). Analysis of a non-structural gene reveals evidence of possible hepatitis C virus (HCV) compartmentalization. . Journal of Medical Virology , 84 (2) , 242-52.
  • Blackard, Jason T (2012). HCV superinfection and reinfection. . Antiviral Therapy , 17 (7 Pt B) , 1443-8.
  • Schwarze-Zander, C., Blackard, J. T., & Rockstroh, J. K. (2012). Role of GB virus C in modulating HIV disease. . Expert Review of Anti-infective Therapy , 10 (5) , 563-72.
  • Gededzha, M. P., Selabe, S. G., Kyaw, T., Rakgole, J. N., Blackard, J. T., & Mphahlele, M. J. (2012). Introduction of new subtypes and variants of hepatitis C virus genotype 4 in South Africa. . Journal of Medical Virology , 84 (4) , 601-7.
  • Martin, C. M., Welge, J. A., & Blackard, J. T. (2011). (In Press). Hepatitis B virus (HBV) X gene diversity and evidence of recombination in HBV/HIV co-infected persons. . Journal of Medical Virology , 83 (7) , 1142-50.
  • Blackard, J. T., Ma, G., Martin, C. M., Rouster, S. D., Shata, M. T., & Sherman, K. E. (2011). (In Press). HIV Variability in the Liver and Evidence of Possible Compartmentalization. . AIDS Research and Human Retroviruses.
  • Neibecker, M., Schwarze-Zander, C., Rockstroh, J. K., Spengler, U., & Blackard, J. T. (2011). (In Press). Evidence for extensive genotypic diversity and recombination of GB virus C (GBV-C) in Germany. . Journal of Medical Virology , 83 (4) , 685-94.
  • Blackard, J. T., Welge, J. A., Taylor, L. E., Mayer, K. H., Klein, R. S., Celentano, D. D., Jamieson, D. J., Gardner, L., & Sherman, K. E. (2011). (In Press). HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - in women. . Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America , 52 (5) , 674-80.
  • Taylor, L. E., DeLong, A. K., Maynard, M. A., Chapman, S., Gholam, P., Blackard, J. T., Rich, J., & Mayer, K. H. (2011). Acute hepatitis C virus in an HIV clinic: a screening strategy, risk factors, and perception of risk. . AIDS Patient Care and STDs , 25 (10) , 571-7.
  • Blackard, J. T., Ma, G., Limketkai, B. N., Welge, J. A., Dryer, P. D., Martin, C. M., Hiasa, Y., Taylor, L. E., Mayer, K. H., Jamieson, D. J., & Sherman, K. E. (2010). (In Press). Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women. . Journal of Clinical Microbiology , 48 (11) , 4256-9.
  • Martin, C. M., Welge, J. A., Shire, N. J., Rouster, S. D., Shata, M. T., Sherman, K. E., & Blackard, J. T. (2010). (In Press). Genomic variability associated with the presence of occult hepatitis B virus in HIV co-infected individuals. . Journal of Viral Hepatitis , 17 (8) , 588-97.
  • Sherman, K. E., Rouster, S. D., Stanford, S., Blackard, J. T., Shire, N., Koziel, M., Peters, M., & Chung, R. T. (2010). (In Press). Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens. . The Journal of Infectious Diseases , 201 (5) , 712-9.
  • Schwarze-Zander, C., Neibecker, M., Othman, S., Tural, C., Clotet, B., Blackard, J. T., Kupfer, B., Luechters, G., Chung, R. T., Rockstroh, J. K., & Spengler, U. (2010). (In Press). GB virus C coinfection in advanced HIV type-1 disease is associated with low CCR5 and CXCR4 surface expression on CD4(+) T-cells. . Antiviral Therapy , 15 (5) , 745-52.
  • Moreno-Fernandez, M. E., Zapata, W., Blackard, J. T., Franchini, G., & Chougnet, C. A. (2009). (In Press). Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain. . Journal of Virology , 83 (24) , 12925-33.
  • Dryer, P. D., Limketkai, B. N., Martin, C. M., Ma, G., Sherman, K. E., Taylor, L. E., Mayer, K. H., Jamieson, D. J., & Blackard, J. T. (2009). (In Press). Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women. . The Journal of Antimicrobial Chemotherapy , 64 (5) , 945-8.
  • Blackard, J. T., Rouster, S. D., Nady, S., Galal, G., Marzuuk, N., Rafaat, M. M., Daef, E., El Din, S. S., Purcell, R. H., Emerson, S. U., Sherman, K. E., & Shata, M. T. (2009). (In Press). Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt. . Journal of Clinical Virology : the Official Publication of the Pan American Society For Clinical Virology , 46 (2) , 140-4.
  • Martin, C. M., Welge, J. A., Shire, N. J., Shata, M. T., Sherman, K. E., & Blackard, J. T. (2009). (In Press). Cytokine expression during chronic versus occult hepatitis B virus infection in HIV co-infected individuals. . Cytokine , 47 (3) , 194-8.
  • Akeno, N., Blackard, J. T., & Tomer, Y. (2008). (In Press). HCV E2 protein binds directly to thyroid cells and induces IL-8 production: a new mechanism for HCV induced thyroid autoimmunity. . Journal of Autoimmunity , 31 (4) , 339-44.
  • Blackard, J. T., & Sherman, K. E. (2008). (In Press). HCV/ HIV co-infection: time to re-evaluate the role of HIV in the liver? . Journal of Viral Hepatitis , 15 (5) , 323-30.
  • Blackard, J. T., Welles, S. L., Ackerman, A., Kalia, N., Cohen, D. E., & Mayer, K. H. (2008). (In Press). Immunological rebound after initiation of highly active antiretroviral therapy in treatment-naive patients. . AIDS Research and Human Retroviruses , 24 (3) , 499-504.
  • Blackard, J. T., Shata, M. T., Shire, N. J., & Sherman, K. E. (2008). (In Press). Acute hepatitis C virus infection: a chronic problem. . Hepatology (Baltimore, Md.) , 47 (1) , 321-31.
  • Rutherford, A. E., Hynan, L. S., Borges, C. B. S., Forcione, D. G., Blackard, J. T., Lin, W., Gorman, A. R., Shaikh, O. S., Reuben, A., Harrison, E., Reddy, K. R., Le, W. M., & Chung, R. T. (2007). (In Press). Serum apoptosis markers in acute liver failure: a pilot study. . Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association , 5 (12) , 1477-83.
  • Tomer, Y., Blackard, J. T., & Akeno, N. (2007). (In Press). Interferon alpha treatment and thyroid dysfunction. . Endocrinology and Metabolism Clinics of North America , 36 (4) , 1051-66; x-xi.
  • Blackard, J. T., Hiasa, Y., Smeaton, L., Jamieson, D. J., Rodriguez, I., Mayer, K. H., & Chung, R. T. (2007). (In Press). Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection. . The Journal of Infectious Diseases , 195 (12) , 1765-73.
  • Blackard, J. T., Kang, M., St Clair, J. B., Lin, W., Kamegaya, Y., Sherman, K. E., Koziel, M. J., Peters, M. G., Andersen, J., & Chung, R. T. (2007). (In Press). Viral factors associated with cytokine expression during HCV/HIV co-infection. . Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research , 27 (4) , 263-9.
  • Shire, N. J., Rouster, S. D., Stanford, S. D., Blackard, J. T., Martin, C. M., Fichtenbaum, C. J., & Sherman, K. E. (2007). (In Press). The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients. . Journal of Acquired Immune Deficiency Syndromes (1999) , 44 (3) , 309-14.
  • Blackard, J. T., & Sherman, K. E. (2007). (In Press). Hepatitis C virus coinfection and superinfection. . The Journal of Infectious Diseases , 195 (4) , 519-24.
  • Blackard, J. T., Kang, M., Sherman, K. E., Koziel, M. J., Peters, M. G., & Chung, R. T. (2006). (In Press). Effects of HCV treatment on cytokine expression during HCV/HIV coinfection. . Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research , 26 (11) , 834-8.
  • Lin, W., Kim, S. S., Yeung, E., Kamegaya, Y., Blackard, J. T., Kim, K. A., Holtzman, M. J., & Chung, R. T. (2006). (In Press). Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. . Journal of Virology , 80 (18) , 9226-35.
  • Schwarze-Zander, C., Blackard, J. T., Zheng, H., Addo, M. M., Lin, W., Robbins, G. K., Sherman, K. E., Zdunek, D., Hess, G., & Chung, R. T. (2006). (In Press). GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype. . The Journal of Infectious Diseases , 194 (4) , 410-9.
  • Blackard, J. T., Kemmer, N., & Sherman, K. E. (2006). (In Press). Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences. . Hepatology (Baltimore, Md.) , 44 (1) , 15-22.
  • Hiasa, Y., Blackard, J. T., Lin, W., Kamegaya, Y., Horiike, N., Onji, M., Schmidt, E. V., & Chung, R. T. (2006). (In Press). Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication. . Journal of Virological Methods , 132 (1-2) , 195-203.
  • Blackard, J. T., Komurian-Pradel, F., Perret, M., Sodoyer, M., Smeaton, L., St Clair, J. B., Chapman, S., Taylor, L. E., Paranhos-Baccalà, G., & Chung, R. T. (2006). (In Press). Intrahepatic cytokine expression is downregulated during HCV/HIV co-infection. . Journal of Medical Virology , 78 (2) , 202-7.
  • Koulinska, I. N., Villamor, E., Msamanga, G., Fawzi, W., Blackard, J., Renjifo, B., & Essex, M. (2006). Risk of HIV-1 transmission by breastfeeding among mothers infected with recombinant and non-recombinant HIV-1 genotypes. . Virus Research , 120 (1-2) , 191-8.
  • Blackard, J. T., Smeaton, L., Hiasa, Y., Horiike, N., Onji, M., Jamieson, D. J., Rodriguez, I., Mayer, K. H., & Chung, R. T. (2005). (In Press). Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons. . The Journal of Infectious Diseases , 192 (2) , 258-65.
  • Lin, W., Choe, W. H., Hiasa, Y., Kamegaya, Y., Blackard, J. T., Schmidt, E. V., & Chung, R. T. (2005). (In Press). Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. . Gastroenterology , 128 (4) , 1034-41.
  • Kamegaya, Y., Hiasa, Y., Zukerberg, L., Fowler, N., Blackard, J. T., Lin, W., Choe, W. H., Schmidt, E. V., & Chung, R. T. (2005). (In Press). Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis. . Hepatology (Baltimore, Md.) , 41 (3) , 660-7.
  • Blackard, J. T., Yang, Y., Bordoni, P., Sherman, K. E., & Chung, R. T. (2004). (In Press). Hepatitis C virus (HCV) diversity in HIV-HCV-coinfected subjects initiating highly active antiretroviral therapy. . The Journal of Infectious Diseases , 189 (8) , 1472-81.
  • Blackard, J. T., & Mayer, K. H. (2004). (In Press). HIV superinfection in the era of increased sexual risk-taking. . Sexually Transmitted Diseases , 31 (4) , 201-4.
  • Meyer-Olson, D., Brady, K. W., Blackard, J. T., Allen, T. M., Islam, S., Shoukry, N. H., Hartman, K., Walker, C. M., & Kalams, S. A. (2003). (In Press). Analysis of the TCR beta variable gene repertoire in chimpanzees: identification of functional homologs to human pseudogenes. . Journal of Immunology (Baltimore, Md. : 1950) , 170 (8) , 4161-9.
  • Blackard, J. T., Cohen, D. E., & Mayer, K. H. (2002). (In Press). Human immunodeficiency virus superinfection and recombination: current state of knowledge and potential clinical consequences. . Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America , 34 (8) , 1108-14.
  • Blackard, J. T., Renjifo, B., Fawzi, W., Hertzmark, E., Msamanga, G., Mwakagile, D., Hunter, D., Spiegelman, D., Sharghi, N., Kagoma, C., & Essex, M. (2001). (In Press). HIV-1 LTR subtype and perinatal transmission. . Virology , 287 (2) , 261-5.
  • Blackard, J. T., Renjifo, B., Chaplin, B., Msamanga, G., Fawzi, W., & Essex, M. (2000). (In Press). Diversity of the HIV-1 long terminal repeat following mother-to-child transmission. . Virology , 274 (2) , 402-11.
  • Renjifo, B., Blackard, J. T., Klaskala, W., Chaplin, B. R., Shah, P., McLane, M. F., Barin, F., Esparza, J., Zelaya, J. E., Osmanov, S., Soto, R., Fernandez, J. A., Baum, M. K., & Essex, M. E. (1999). (In Press). HIV-1 subtype B in Honduras. . Virus Research , 60 (2) , 191-7.
  • Blackard, J. T., Renjifo, B. R., Mwakagile, D., Montano, M. A., Fawzi, W. W., & Essex, M. (1999). (In Press). Transmission of human immunodeficiency type 1 viruses with intersubtype recombinant long terminal repeat sequences. . Virology , 254 (2) , 220-5.
  • Maeda, N., Kawamura, T., Hoshino, H., Yamada, N., Blackard, J., Kushida, S., Miyano-Kurosaki, N., Yamamoto, N., Makino, K., Yokota, T., Uchida, K., & Miwa, M. (1998). Inhibition of human T-cell leukemia virus type 1 replication by antisense env oligodeoxynucleotide. . Biochemical and Biophysical Research Communications , 243 (1) , 109-12.
  • Montano, M. A., Novitsky, V. A., Blackard, J. T., Cho, N. L., Katzenstein, D. A., & Essex, M. (1997). (In Press). Divergent transcriptional regulation among expanding human immunodeficiency virus type 1 subtypes. . Journal of Virology , 71 (11) , 8657-65.
  • Choudhury, S., Montano, M. A., Womack, C., Blackard, J. T., Maniar, J. K., Saple, D. G., Tripathy, S., Sahni, S., Shah, S., Babu, G. P., & Essex, M. (In Press). Increased promoter diversity reveals a complex phylogeny of human immunodeficiency virus type 1 subtype C in India. . Journal of Human Virology , 3 (1) , 35-43.

    Research Grants:

  • R21 AI081564 NIH/NIAID. Clinical Relevance of GB Virus C Interactions with HIV and Hepatitis C Virus in High Risk Women The major goals of this project are to determine the role of GBV-C co-infection on HIV disease progression in women, as well as evaluate the role of GBV-C genotype in HIV disease, PI
  • Investigator Initiated Study - Merck Inc.. Exploring the Effects of HIV on Hepatitis C Virus Replication In Vitro The major goals of this project are to examine the effects of soluble HIV proteins and of HIV infection on HCV replication kinetics in vitro and to identify cellular factors that contribute to HIV-mediated enhancement of HCV replication, PI
  • R01 AI065256 NIH/NIAID. Antiretroviral Therapy and the Hepatitis C Virus The major goals of this project are to develop and perform a clinical intervention trial in HCV/HIV co-infected subjects treated with ART in order to characterize HCV and HIV viral kinetics as well as the prevalence, significance, and pathogenesis of HCV viral load increases, Co-Investigator
  • UC/CCHMC Digestive Health Center/ NIH. Digestive Health Center Pilot Award - Functional Analysis of Hepatitis B Virus Surface Mutations The major goals of this project are to examine the biological mechanisms for the lack of surface antigen detection during occult hepatitis B virus infection, PI
  • University of Cincinnati College of Medicine. Dean's Scholar Program - HIV Infection of the Lever The major goal of this project is to examine HCV/HIV co-infection via detection and genetic characterization of HIV RNA and proviral DNA in liver biopsy tissues and matched serum/PBMC samples from HCV/HIV co-infected persons, PI
  • R21 DA022148 National Institute on Drug Abuse. Extrahepatic Replication and Viral Evolution of HCV during HCV/HIV Co-Infection, PI, Closed.
  • SRS 004175 Bristol-Myers Squibb Co.. Characterization of the Hepatitis B Virus in HIV+ Patients, PI, Closed.
  • SRS 005925 Department of Veterans Affairs. Intergovernmental Personnel Act Agreement for Jason Blackard, PI, Closed.
  • R21 AI081564 National Institute of Allergy and Infectious Diseases. Clinical Relevance of GB Virus C Interactions with HIV and Hepatitis C Virus in High Risk Women, PI, Closed.
  • SRS006742 Merck & Co., Inc.. Exploring the Effects of HIV on Hepatitis C Virus Replication in Vitro, PI, Closed.
  • 103952 / P30 DK78392 National Inst of Diabetes and Digestive and Kidney Disease. Functional Analysis of Hepatitis B Virus Surface Mutations, PI, Closed.
  • PO 526-005018 Department of Veterans Affairs. Drug and Viral Induced Thyroiditis, PI, Closed.
  • R21 AI096958 National Institute of Allergy and Infectious Diseases. Occult Hepatitis B Infection in South Africa, PI, Active.
  • SRS 007837 Merck Sharp & Dohme Corp. Evaluating the Role of the Immune Responses in the Emergence of HCV NS3 Resistance Mutations During Protease Inhibitor Therapy, Collaborator, Active.
  • 108400 \ UM1A1068636 National Institute of Allergy and Infectious Diseases. Characterization of HCV Resistance Associated Variants in Liver Tissue, Collaborator, Active.
  • R01 GM105414 National Institute of General Medical Sciences. Genotypic and Phenotypic Characterization of the HCV Polymerase (NS5B), PI, Active.
  • SRS 008469 Department of Veterans Affairs. Drug and Viral Induced Thyroiditis and Diabetes, PI, Awarded.

Recent Awards/Honors:

  • Forty Under 40 Award. Cincinnati Business Courier, 2009
  • Faculty Development Award. University of Cincinnati, 2009
  • American Society of Microbiology Young Investigator Award. University of Cincinnati, 2007
  • Dean's Scholar Program. University of Cincinnati, 2007
  • Graduate Teacher of the Year. University of Cincinnati, 2007
  • HIV & Liver Disease conference travel award. University of Cincinnati, 2006
  • Academy of Fellows for Teaching & Learning. University of Cincinnati, 2013
  • Faculty Travel Award. University of Cincinnati, 2012
  • Faculty Travel Award. University of Cincinnati, 2013
  • Education Abroad Development Grant. University of Cincinnati, 2013
  • Education Abroad Development Grant. University of Cincinnati, 2012
  • International Professorship in Africa. American Society for Microbiology, 2011
  • Faculty Development Award. University of Cincinnati, 2010
  • Mary Weston Fellowship, Visiting Professor. University of KwaZulu-Natal, 2007
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More Information


For more information on the UC Department of Internal Medicine, please contact us at:

UC Department of Internal Medicine
231 Albert Sabin Way
Medical Sciences Building Room 6065
PO Box 670557
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Phone: 513-558-4231
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