Department Directory


    Research/Clinical Interests:

  • Regulation of Insulin Secretion in Diabetes by Hormones and Neural Signals, Metabolic Effects of Glucagon-like Peptide 1, Control of Food Intake by Intestinal Hormones, Mechanisms of Action for Bariatric Surgery.

    Education/Credentials:

  • Bachelor's Degree: Carleton College, 1979
  • Medical Degree: University of Wisconsin, 1983
  • Residency: Temple University Hospital , 1986
  • Research Associate : Temple University , 1987
  • Research Fellowship: University of Washington , 1990

Board Certifications & Licenses:

  • Pennsylvania, 1983
  • Washington, 1987
  • Ohio, 1999
  • Diplomate, American Board of Internal Medicine, 1987
  • Diplomate, American Subspecialty Board, Endocrinology & Metabolism, 1990

Peer Reviewed Publications (in chronological order):

  • Liu, M., Shen, L., Begg, D. P., D'alessio, D. A., & Woods, S. C. (2012). Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats. . Journal of Neuroscience Methods , 209 (1) , 106-12.
  • Mul, J. D., Begg, D. P., Alsters, S. I. M., Haaften, G. v., Duran, K. J., D'Alessio, D. A., le Roux, C. W., Woods, S. C., Sandoval, D. A., Blakemore, A. I. F., Cuppen, E., van Haelst, M. M., & Seeley, R. J. (2012). Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. . American Journal of Physiology. Endocrinology and Metabolism , 303 (1) , E103-10.
  • Salehi, M., Aulinger, B., & D'Alessio, D. A. (2012). Effect of Glycemia on Plasma Incretins and the Incretin Effect During Oral Glucose Tolerance Test. . Diabetes.
  • Elder, D. A., Herbers, P. M., Weis, T., Standiford, D., Woo, J. G., & D'Alessio, D. A. (2012). ?-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus. . The Journal of Pediatrics , 160 (6) , 904-10.
  • Rebholz, S. L., Jones, T., Burke, K. T., Jaeschke, A., Tso, P., D'Alessio, D. A., & Woollett, L. A. (2012). Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. . American Journal of Physiology. Endocrinology and Metabolism , 302 (4) , E449-57.
  • Chambers, A. P., Stefater, M. A., Wilson-Perez, H. E., Jessen, L., Sisley, S., Ryan, K. K., Gaitonde, S., Sorrell, J. E., Toure, M., Berger, J., D'Alessio, D. A., Sandoval, D. A., Seeley, R. J., & Woods, S. C. (2011). Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. . Physiology & Behavior , 105 (1) , 120-3.
  • Summer, S. S., Brehm, B. J., Benoit, S. C., & D'Alessio, D. A. (2011). Adiponectin changes in relation to the macronutrient composition of a weight-loss diet. . Obesity (Silver Spring, Md.) , 19 (11) , 2198-204.
  • Salehi, M., Prigeon, R. L., & D'Alessio, D. A. (2011). Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans. . Diabetes , 60 (9) , 2308-14.
  • Chambers, A. P., Jessen, L., Ryan, K. K., Sisley, S., Wilson-Pérez, H. E., Stefater, M. A., Gaitonde, S. G., Sorrell, J. E., Toure, M., Berger, J., D'Alessio, D. A., Woods, S. C., Seeley, R. J., & Sandoval, D. A. (2011). Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. . Gastroenterology , 141 (3) , 950-8.
  • D'Alessio, David A (2011). What if gut hormones aren't really hormones: DPP-4 inhibition and local action of GLP-1 in the gastrointestinal tract. . Endocrinology , 152 (8) , 2925-6.
  • Barrera, J. G., Sandoval, D. A., D'Alessio, D. A., & Seeley, R. J. (2011). GLP-1 and energy balance: an integrated model of short-term and long-term control. . Nature Reviews. Endocrinology , 7 (9) , 507-16.
  • Barrera, J. G., Jones, K. R., Herman, J. P., D'Alessio, D. A., Woods, S. C., & Seeley, R. J. (2011). Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 31 (10) , 3904-13.
  • Kindel, T. L., Martins, P. J. F., Yoder, S. M., Jandacek, R. J., Seeley, R. J., D'Alessio, D. A., Obici, S., & Tso, P. (2011). Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents. . Obesity (Silver Spring, Md.) , 19 (2) , 380-7.
  • Zhang, R., Jankord, R., Flak, J. N., Solomon, M. B., D'Alessio, D. A., & Herman, J. P. (2010). Role of glucocorticoids in tuning hindbrain stress integration. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 30 (44) , 14907-14.
  • Kohli, R., Kirby, M., Setchell, K. D. R., Jha, P., Klustaitis, K., Woollett, L. A., Pfluger, P. T., Balistreri, W. F., Tso, P., Jandacek, R. J., Woods, S. C., Heubi, J. E., Tschoep, M. H., D'Alessio, D. A., Shroyer, N. F., & Seeley, R. J. (2010). Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 299 (3) , G652-60.
  • Elder, D. A., Woo, J. G., & D'Alessio, D. A. (2010). Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. . Pediatric Diabetes , 11 (5) , 314-21.
  • Lê, K., D'Alessio, D. A., & Tappy, L. (2010). Metabolic effects of excess energy intake: does food composition matter? . Current Opinion in Clinical Nutrition and Metabolic Care , 13 (4) , 429-31.
  • D'Alessio, David A (2010). Taking aim at islet hormones with GLP-1: is insulin or glucagon the better target? . Diabetes , 59 (7) , 1572-4.
  • Diab, D. L., & D'Alessio, D. A. (2010). The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus. . Current Diabetes Reports , 10 (3) , 192-8.
  • Salehi, M., Aulinger, B., Prigeon, R. L., & D'Alessio, D. A. (2010). Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes. . Diabetes , 59 (6) , 1330-7.
  • Kindel, T. L., Yoder, S. M., D'Alessio, D. A., & Tso, P. (2010). The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats. . Obesity Surgery , 20 (6) , 768-75.
  • Pérez-Tilve, D., González-Matías, L., Aulinger, B. A., Alvarez-Crespo, M., Gil-Lozano, M., Alvarez, E., Andrade-Olivie, A. M., Tschöp, M. H., D'Alessio, D. A., & Mallo, F. (2010). Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system. . American Journal of Physiology. Endocrinology and Metabolism , 298 (5) , E1088-96.
  • Vahl, T. P., Drazen, D. L., Seeley, R. J., D'Alessio, D. A., & Woods, S. C. (2010). Meal-anticipatory glucagon-like peptide-1 secretion in rats. . Endocrinology , 151 (2) , 569-75.
  • Falciglia, M., Freyberg, R. W., Almenoff, P. L., D'Alessio, D. A., & Render, M. L. (2009). Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. . Critical Care Medicine , 37 (12) , 3001-9.
  • Barrera, J. G., D'Alessio, D. A., Drucker, D. J., Woods, S. C., & Seeley, R. J. (2009). Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. . Diabetes , 58 (12) , 2820-7.
  • Kindel, T. L., Yoder, S. M., Seeley, R. J., D'Alessio, D. A., & Tso, P. (2009). Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. . Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract , 13 (10) , 1762-72.
  • Cota, D., Sandoval, D. A., Olivieri, M., Prodi, E., D'Alessio, D. A., Woods, S. C., Seeley, R. J., & Obici, S. (2009). Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. . Obesity (Silver Spring, Md.) , 17 (8) , 1641-5.
  • Kim, D., D'Alessio, D. A., Woods, S. C., & Seeley, R. J. (2009). The effects of GLP-1 infusion in the hepatic portal region on food intake. . Regulatory Peptides , 155 (1-3) , 110-4.
  • Zhang, R., Packard, B. A., Tauchi, M., D'Alessio, D. A., & Herman, J. P. (2009). Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress. . Proceedings of the National Academy of Sciences of the United States of America , 106 (14) , 5913-8.
  • Brehm, B. J., Lattin, B. L., Summer, S. S., Boback, J. A., Gilchrist, G. M., Jandacek, R. J., & D'Alessio, D. A. (2009). One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes. . Diabetes Care , 32 (2) , 215-20.
  • Shertzer, H. G., Schneider, S. N., Kendig, E. L., Clegg, D. J., D'Alessio, D. A., Johansson, E., & Genter, M. B. (2009). Tetrahydroindenoindole inhibits the progression of diabetes in mice. . Chemico-biological Interactions , 177 (1) , 71-80.
  • D'Alessio, D. A., Denney, A. M., Hermiller, L. M., Prigeon, R. L., Martin, J. M., Tharp, W. G., Saylan, M. L., He, Y., Dunning, B. E., Foley, J. E., & Pratley, R. E. (2009). Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes. . The Journal of Clinical Endocrinology and Metabolism , 94 (1) , 81-8.
  • Tauchi, M., Zhang, R., D'Alessio, D. A., Stern, J. E., & Herman, J. P. (2008). Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei. . Journal of Chemical Neuroanatomy , 36 (3-4) , 144-9.
  • Salehi, M., Vahl, T. P., & D'Alessio, D. A. (2008). Regulation of islet hormone release and gastric emptying by endogenous glucagon-like peptide 1 after glucose ingestion. . The Journal of Clinical Endocrinology and Metabolism , 93 (12) , 4909-16.
  • Woods, S. C., & D'Alessio, D. A. (2008). Central control of body weight and appetite. . The Journal of Clinical Endocrinology and Metabolism , 93 (11 Suppl 1) , S37-50.
  • Brehm, B. J., & D'Alessio, D. A. (2008). Benefits of high-protein weight loss diets: enough evidence for practice? . Current Opinion in Endocrinology, Diabetes, and Obesity , 15 (5) , 416-21.
  • Perez-Tilve, D., D'Alessio, D. A., & Tschöp, M. H. (2008). A sweet spot for the bariatric surgeon. . Cell Metabolism , 8 (3) , 177-9.
  • Sandoval, D. A., Bagnol, D., Woods, S. C., D'Alessio, D. A., & Seeley, R. J. (2008). Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. . Diabetes , 57 (8) , 2046-54.
  • Elder, D. A., D'Alessio, D. A., Eyal, O., Mueller, R., Smith, F. O., Kansra, A. R., & Rose, S. R. (2008). Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion. . Pediatric Blood & Cancer , 51 (2) , 256-60.
  • Strawn, J. R., D'Alessio, D. A., Keck, P. E., & Seeley, R. J. (2008). Failure of glucagon-like peptide-1 to induce panic attacks or anxiety in patients with panic disorder. . Journal of Psychiatric Research , 42 (9) , 787-9.
  • Salehi, M., Aulinger, B. A., & D'Alessio, D. A. (2008). Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins. . Endocrine Reviews , 29 (3) , 367-79.
  • Reed, J. A., Benoit, S. C., Pfluger, P. T., Tschöp, M. H., D'Alessio, D. A., & Seeley, R. J. (2008). Mice with chronically increased circulating ghrelin develop age-related glucose intolerance. . American Journal of Physiology. Endocrinology and Metabolism , 294 (4) , E752-60.
  • Tauchi, M., Zhang, R., D'Alessio, D. A., Seeley, R. J., & Herman, J. P. (2008). Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress. . Experimental Neurology , 210 (2) , 458-66.
  • Gray, D. L., O'Brien, K. D., D'Alessio, D. A., Brehm, B. J., & Deeg, M. A. (2008). Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women. . Metabolism: Clinical and Experimental , 57 (4) , 473-8.
  • Kemp, C. J., D'Alessio, D. A., Scott, R. O., Kelm, G. R., Meller, S. T., Barrera, J. G., Seeley, R. J., Clegg, D. J., & Benoit, S. C. (2008). Voluntary consumption of ethyl oleate reduces food intake and body weight in rats. . Physiology & Behavior , 93 (4-5) , 912-8.
  • Shertzer, H. G., Schneider, S. N., Kendig, E. L., Clegg, D. J., D'Alessio, D. A., & Genter, M. B. (2008). Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. . Biochemical Pharmacology , 75 (6) , 1402-10.
  • Brehm, B. J., & D'Alessio, D. A. (2008). Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff. . Nature Clinical Practice. Endocrinology & Metabolism , 4 (3) , 140-6.
  • Rodieux, F., Giusti, V., D'Alessio, D. A., Suter, M., & Tappy, L. (2008). Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. . Obesity (Silver Spring, Md.) , 16 (2) , 298-305.
  • Elder, D. A., Wooldridge, J. L., Dolan, L. M., & D'Alessio, D. A. (2007). Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes. . The Journal of Pediatrics , 151 (6) , 653-8.
  • Vahl, T. P., Tauchi, M., Durler, T. S., Elfers, E. E., Fernandes, T. M., Bitner, R. D., Ellis, K. S., Woods, S. C., Seeley, R. J., Herman, J. P., & D'Alessio, D. A. (2007). Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. . Endocrinology , 148 (10) , 4965-73.
  • Lê, K., Tappy, L., & D'Alessio, D. A. (2007). Mitochondrial dysfunction and insulin resistance: a matter of lifestyle? . Current Opinion in Clinical Nutrition and Metabolic Care , 10 (4) , 494-7.
  • Pfluger, P. T., Kampe, J., Castaneda, T. R., Vahl, T., D'Alessio, D. A., Kruthaupt, T., Benoit, S. C., Cuntz, U., Rochlitz, H. J., Moehlig, M., Pfeiffer, A. F. H., Koebnick, C., Weickert, M. O., Otto, B., Spranger, J., & Tschöp, M. H. (2007). Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. . The Journal of Clinical Endocrinology and Metabolism , 92 (2) , 583-8.
  • McElroy, S. L., Kotwal, R., Guerdjikova, A. I., Welge, J. A., Nelson, E. B., Lake, K. A., D'Alessio, D. A., Keck, P. E., & Hudson, J. I. (2006). Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial. . The Journal of Clinical Psychiatry , 67 (12) , 1897-906.
  • Watts, N. B., & D'Alessio, D. A. (2006). Type 2 diabetes, thiazolidinediones: bad to the bone? . The Journal of Clinical Endocrinology and Metabolism , 91 (9) , 3276-8.
  • Salehi, M., & D'Alessio, D. A. (2006). New therapies for type 2 diabetes based on glucagon-like peptide 1. . Cleveland Clinic Journal of Medicine , 73 (4) , 382-9.
  • Drazen, D. L., Vahl, T. P., D'Alessio, D. A., Seeley, R. J., & Woods, S. C. (2006). Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. . Endocrinology , 147 (1) , 23-30.
  • Elder, D. A., Prigeon, R. L., Wadwa, R. P., Dolan, L. M., & D'Alessio, D. A. (2006). Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults. . The Journal of Clinical Endocrinology and Metabolism , 91 (1) , 185-91.
  • D'Alessio, D. A., Sandoval, D. A., & Seeley, R. J. (2005). New ways in which GLP-1 can regulate glucose homeostasis. . The Journal of Clinical Investigation , 115 (12) , 3406-8.
  • Vahl, T. P., Ulrich-Lai, Y. M., Ostrander, M. M., Dolgas, C. M., Elfers, E. E., Seeley, R. J., D'Alessio, D. A., & Herman, J. P. (2005). Comparative analysis of ACTH and corticosterone sampling methods in rats. . American Journal of Physiology. Endocrinology and Metabolism , 289 (5) , E823-8.
  • D'Alessio, D. A., & Vahl, T. P. (2005). Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches. . Current Diabetes Reports , 5 (5) , 346-52.
  • Proulx, K., Cota, D., Castañeda, T. R., Tschöp, M. H., D'Alessio, D. A., Tso, P., Woods, S. C., & Seeley, R. J. (2005). Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 289 (3) , R729-37.
  • D'Alessio, D. A., Lê, K., & Tappy, L. (2005). Type 2 diabetes and insulin resistance: an hepatocentric phenomenon? . Current Opinion in Clinical Nutrition and Metabolic Care , 8 (4) , 428-30.
  • Qin, X., Shen, H., Liu, M., Yang, Q., Zheng, S., Sabo, M., D'Alessio, D. A., & Tso, P. (2005). GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 288 (5) , G943-9.
  • O'Brien, K. D., Brehm, B. J., Seeley, R. J., Bean, J., Wener, M. H., Daniels, S., & D'Alessio, D. A. (2005). Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects. . The Journal of Clinical Endocrinology and Metabolism , 90 (4) , 2244-9.
  • Brehm, B. J., Spang, S. E., Lattin, B. L., Seeley, R. J., Daniels, S. R., & D'Alessio, D. A. (2005). The role of energy expenditure in the differential weight loss in obese women on low-fat and low-carbohydrate diets. . The Journal of Clinical Endocrinology and Metabolism , 90 (3) , 1475-82.
  • Strader, A. D., Vahl, T. P., Jandacek, R. J., Woods, S. C., D'Alessio, D. A., & Seeley, R. J. (2005). Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. . American Journal of Physiology. Endocrinology and Metabolism , 288 (2) , E447-53.
  • Lachey, J. L., D'Alessio, D. A., Rinaman, L., Elmquist, J. K., Drucker, D. J., & Seeley, R. J. (2005). The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. . Endocrinology , 146 (1) , 458-62.
  • Wray, C. J., Ahmad, S. A., Lowy, A. M., D'Alessio, D. A., Gelrud, A., Choe, K. A., Soldano, D. A., Matthews, J. B., & Rodriguez-Rilo, H. L. (2005). Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions. . Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.] , 5 (6) , 562-9.
  • Woods, S. C., D'Alessio, D. A., Tso, P., Rushing, P. A., Clegg, D. J., Benoit, S. C., Gotoh, K., Liu, M., & Seeley, R. J. (2004). Consumption of a high-fat diet alters the homeostatic regulation of energy balance. . Physiology & Behavior , 83 (4) , 573-8.
  • D'Alessio, D. A., & Vahl, T. P. (2004). Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes. . American Journal of Physiology. Endocrinology and Metabolism , 286 (6) , E882-90.
  • Seeley, R. J., D'Alessio, D. A., & Woods, S. C. (2004). Fat hormones pull their weight in the CNS. . Nature Medicine , 10 (5) , 454-5.
  • Vahl, T. P., & D'Alessio, D. A. (2004). Gut peptides in the treatment of diabetes mellitus. . Expert Opinion on Investigational Drugs , 13 (3) , 177-88.
  • Prigeon, R. L., Quddusi, S., Paty, B., & D'Alessio, D. A. (2003). Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect. . American Journal of Physiology. Endocrinology and Metabolism , 285 (4) , E701-7.
  • Ehlers, M. R., Klaff, L. J., D'Alessio, D. A., Brazg, R., Kay, H. D., Harley, R. E., Mathisen, A. L., & Schneider, R. (2003). Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes. . Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et M & #233;tabolisme , 35 (10) , 611-6.
  • Ensinck, J. W., Laschansky, E. C., Vogel, R. E., & D'Alessio, D. A. (2003). Effect of ingested nutrients on the release of thrittene into the human circulation. . The Journal of Clinical Endocrinology and Metabolism , 88 (10) , 4798-804.
  • Henchoz, E., D'Alessio, D. A., Gillet, M., Halkic, N., Matzinger, O., Goy, J., Chioléro, R., Tappy, L., & Schneiter, P. (2003). Impaired insulin response after oral but not intravenous glucose in heart- and liver-transplant recipients. . Transplantation , 76 (6) , 923-9.
  • Kinzig, K. P., D'Alessio, D. A., Herman, J. P., Sakai, R. R., Vahl, T. P., Figueiredo, H. F., Murphy, E. K., Seeley, R. J., & Figueredo, H. F. (2003). CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 23 (15) , 6163-70.
  • Vahl, T. P., Paty, B. W., Fuller, B. D., Prigeon, R. L., & D'Alessio, D. A. (2003). Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. . The Journal of Clinical Endocrinology and Metabolism , 88 (4) , 1772-9.
  • Brehm, B. J., Seeley, R. J., Daniels, S. R., & D'Alessio, D. A. (2003). A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. . The Journal of Clinical Endocrinology and Metabolism , 88 (4) , 1617-23.
  • Quddusi, S., Vahl, T. P., Hanson, K., Prigeon, R. L., & D'Alessio, D. A. (2003). Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans. . Diabetes Care , 26 (3) , 791-8.
  • Kinzig, K. P., D'Alessio, D. A., & Seeley, R. J. (2002). The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 22 (23) , 10470-6.
  • Ensinck, J. W., Baskin, D. G., Vahl, T. P., Vogel, R. E., Laschansky, E. C., Francis, B. H., Hoffman, R. C., Krakover, J. D., Stamm, M. R., Low, M. J., Rubinstein, M., Otero-Corchon, V., & D'Alessio, D. A. (2002). Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation. . Endocrinology , 143 (7) , 2599-609.
  • Greenbaum, C. J., Prigeon, R. L., & D'Alessio, D. A. (2002). Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose. . Diabetes , 51 (4) , 951-7.
  • Tamashiro, K. L. K., Wakayama, T., Akutsu, H., Yamazaki, Y., Lachey, J. L., Wortman, M. D., Seeley, R. J., D'Alessio, D. A., Woods, S. C., Yanagimachi, R., & Sakai, R. R. (2002). Cloned mice have an obese phenotype not transmitted to their offspring. . Nature Medicine , 8 (3) , 262-7.
  • Rushing, P. A., Hagan, M. M., Seeley, R. J., Lutz, T. A., D'Alessio, D. A., Air, E. L., & Woods, S. C. (2001). Inhibition of central amylin signaling increases food intake and body adiposity in rats. . Endocrinology , 142 (11) , 5035.
  • D'Alessio, D. A., Kieffer, T. J., Taborsky, G. J., & Havel, P. J. (2001). Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. . The Journal of Clinical Endocrinology and Metabolism , 86 (3) , 1253-9.
  • Verchere, C. B., D'Alessio, D. A., Prigeon, R. L., Hull, R. L., & Kahn, S. E. (2000). The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells. . Diabetes , 49 (9) , 1477-84.
  • Owen, O. E., Smalley, K. J., D'Alessio, D. A., Mozzoli, M. A., & Dawson, E. K. (1998). Protein, fat, and carbohydrate requirements during starvation: anaplerosis and cataplerosis. . The American Journal of Clinical Nutrition , 68 (1) , 12-34.
  • Ensinck, J. W., Vogel, R. E., Laschansky, E. C., Koerker, D. J., Prigeon, R. L., Kahn, S. E., & D'Alessio, D. A. (1997). Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons. . The Journal of Clinical Investigation , 100 (9) , 2295-302.
  • Verchere, C. B., D'Alessio, D. A., Wang, S., Andrikopoulos, S., & Kahn, S. E. (1997). Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation. . Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et M & #233;tabolisme , 29 (6) , 311-6.
  • Verchere, C. B., D'Alessio, D. A., Palmiter, R. D., Weir, G. C., Bonner-Weir, S., Baskin, D. G., & Kahn, S. E. (1996). Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. . Proceedings of the National Academy of Sciences of the United States of America , 93 (8) , 3492-6.
  • D'Alessio, D. A., Vogel, R., Prigeon, R., Laschansky, E., Koerker, D., Eng, J., & Ensinck, J. W. (1996). Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons. . The Journal of Clinical Investigation , 97 (1) , 133-8.
  • D'Alessio, D. A., Prigeon, R. L., & Ensinck, J. W. (1995). Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I. . Diabetes , 44 (12) , 1433-7.
  • D'Alessio, D. A., Verchere, C. B., Kahn, S. E., Hoagland, V., Baskin, D. G., Palmiter, R. D., & Ensinck, J. W. (1994). Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse. . Diabetes , 43 (12) , 1457-61.
  • Verchere, C. B., D'Alessio, D. A., Palmiter, R. D., & Kahn, S. E. (1994). Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro. . Diabetologia , 37 (7) , 725-8.
  • D'Alessio, D. A., Kahn, S. E., Leusner, C. R., & Ensinck, J. W. (1994). Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. . The Journal of Clinical Investigation , 93 (5) , 2263-6.
  • Baskin, D. G., Schwartz, M. W., Sipols, A. J., D'Alessio, D. A., Goldstein, B. J., & White, M. F. (1994). Insulin receptor substrate-1 (IRS-1) expression in rat brain. . Endocrinology , 134 (4) , 1952-5.
  • Kahn, S. E., Verchere, C. B., D'Alessio, D. A., Cook, D. L., & Fujimoto, W. Y. (1993). Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway. . Diabetologia , 36 (6) , 570-3.
  • Boswell, T., Richardson, R. D., Schwartz, M. W., D'Alessio, D. A., Woods, S. C., Sipols, A. J., Baskin, D. G., & Kenagy, G. J. (1993). NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding. . Brain Research Bulletin , 32 (4) , 379-84.
  • Ensinck, J. W., & D'Alessio, D. A. (1992). The enteroinsular axis revisited. A novel role for an incretin. . The New England Journal of Medicine , 326 (20) , 1352-3.
  • Owen, O. E., Mozzoli, M. A., Smalley, K. J., Kavle, E. C., & D'Alessio, D. A. (1992). Oxidative and nonoxidative macronutrient disposal in lean and obese men after mixed meals. . The American Journal of Clinical Nutrition , 55 (3) , 630-6.
  • Kahn, S. E., Fujimoto, W. Y., D'Alessio, D. A., Ensinck, J. W., & Porte, D. (1991). Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell. . Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et M & #233;tabolisme , 23 (12) , 577-80.
  • Ensinck, J. W., Laschansky, E. C., Vogel, R. E., & D'Alessio, D. A. (1991). Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas. . Diabetes , 40 (9) , 1163-9.
  • D'Alessio, D. A., & Ensinck, J. W. (1990). Fasting and postprandial concentrations of somatostatin-28 and somatostatin-14 in type II diabetes in men. . Diabetes , 39 (10) , 1198-202.
  • Kahn, S. E., D'Alessio, D. A., Schwartz, M. W., Fujimoto, W. Y., Ensinck, J. W., Taborsky, G. J., & Porte, D. (1990). Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells. . Diabetes , 39 (5) , 634-8.
  • Owen, O. E., Smalley, K. J., D'Alessio, D. A., Mozzoli, M. A., Knerr, A. N., Kendrick, Z. V., Kavle, E. C., Donohoe, M., Tappy, L., & Boden, G. (1990). Resting metabolic rate and body composition of achondroplastic dwarfs. . Medicine , 69 (1) , 56-67.
  • D'Alessio, D. A., Fujimoto, W. Y., & Ensinck, J. W. (1989). Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. . Diabetes , 38 (12) , 1534-8.
  • D'Alessio, D. A., Sieber, C., Beglinger, C., & Ensinck, J. W. (1989). A physiologic role for somatostatin 28 as a regulator of insulin secretion. . The Journal of Clinical Investigation , 84 (3) , 857-62.
  • D'Alessio, D. A., Kavle, E. C., Mozzoli, M. A., Smalley, K. J., Polansky, M., Kendrick, Z. V., Owen, L. R., Bushman, M. C., Boden, G., & Owen, O. E. (1988). Thermic effect of food in lean and obese men. . The Journal of Clinical Investigation , 81 (6) , 1781-9.
  • Owen, O. E., Holup, J. L., D'Alessio, D. A., Craig, E. S., Polansky, M., Smalley, K. J., Kavle, E. C., Bushman, M. C., Owen, L. R., & Mozzoli, M. A. (1987). A reappraisal of the caloric requirements of men. . The American Journal of Clinical Nutrition , 46 (6) , 875-85.
  • Brehm, B. J., Gates, D. M., Singler, M., Succop, P. A., & D'Alessio, D. A. Environmental changes to control obesity: a randomized controlled trial in manufacturing companies. . American Journal of Health Promotion : AJHP , 25 (5) , 334-40.

    Research Grants:

  • GLP1 Eli Lilly and Company. Role of GLP-1 Signaling on Insulin Secretion and Islet Mass Following Intrahepatic, PI, Closed.
  • 3-R01-DK-57900-03-A0-S1-E0 National Inst of Diabetes and Digestive and Kidney Disease. GLP-1 in Normal and Abnormal Glucose Tolerance, PI, Closed.
  • R01 DK057900 National Inst of Diabetes and Digestive and Kidney Disease. The Role of GLP-1 in Normal and Abnormal Glucose Tolerance, PI, Closed.
  • 5-R01-DK-57900-03-A0-S0-E0 National Inst of Diabetes and Digestive and Kidney Disease. GLP-1 in Normal and Abnormal Glucose Tolerance, PI, Closed.
  • ADA-22-03-A0-S0-E0 American Diabetes Association. Secretion Metabolism and Action of Glucagon-Like Peptide 1 and Related Peptides in Healthy and Diabetic Humans, PI, Closed.
  • Procter & Gamble Company. Performance of Certain Tests to Obtain Numerial Data and/or Other Information, PI, Closed.
  • American Diabetes Association. Regulation and Adaptation of B-Cell function in Interahepatic Islet Auto-transplantation, PI, Closed.
  • CHMC 102730 / M01 RR08084 National Center for Research Resources. General Clinical Research Center, PI, Closed.
  • R01 DK054890 National Inst of Diabetes and Digestive and Kidney Disease. CNS GLP-1 Signaling in Energy and Glucose Homeostasis, Collaborator, Closed.
  • SRS 005156 University of Texas Southwestern Medical Center at Dallas. Hormone Measurement, PI, Closed.
  • SRS 006299 Eli Lilly and Company. Mechanisms of Action of Exendin-4 and GLP-1 to Reduce Food-Intake and Regulate Body Weight, PI, Closed.
  • 2 R01 DK057900-08A1 National Inst of Diabetes and Digestive and Kidney Disease. The Role of GLP-1 in Normal and Abnormal Glucose Tolerance, PI, Active.
  • 0255-3631-4609 / 7 R01 DK073681-04 National Inst of Diabetes and Digestive and Kidney Disease. Thyroglobulin Peptide Presentation by HLA-DR in Thyroiditis, PI, Closed.
  • 20497-36 / U24 DK076169 National Inst of Diabetes and Digestive and Kidney Disease. Increased Risk for Diabetes and Obesity in Offspring of Multiparous Mice, Collaborator, Active.
  • 25034-10/U24 DK076169 National Inst of Diabetes and Digestive and Kidney Disease. Risk of Multi-generational Programming in Offspring of Multiparous Mice, Collaborator, Closed.
  • S-GRD1213-KR6 \ U01DK098246 National Inst of Diabetes and Digestive and Kidney Disease. The Glycemia Reduction Approaches for Diabetes: A Comparative Effectiveness Study, Collaborator, Active.
  • 008654 Givaudan Flavor Corporation. Validating taste receptor-GLP-1 interactions, Collaborator, Closed.

Recent Awards/Honors:

  • Sol Sherry Award. Clinical Research, Temple Unviersity, 1987
  • National Research Service Award (NRSA). NIH, 1988,1980
  • Clinical Associate Physician. Clinical Research Center, University of Washington, 1990,1992
  • Diabetes Research Council Young Investigator Award. University of Washington, 1990,1992
  • Basic Science Research Grant. University of Washington, 1991
  • Clinical Nutrition Research Unit Young Investigator Award. University of Washington, 1992,1994
  • Clinical Investigator Development Award (K08), NIH, 1994,1998
  • Howard Hughes Medical Institute Research Resources Program Award. University of Washington, 1997
  • American Diabetes Association Clinical Research Award, 1998,2001
  • Western Society for Clinical Investigation. elected member, 1998
  • Paul Beeson Award for Clinical Teaching. University of Washington, 1998
  • Councilar-at-large, AFMR, 1998,2000
  • Secretary-treasurer, AFMR, 2000,to Present
  • Vontz Chair for Diabetes Research. University of Cincinnati, 2000
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