Department Directory

  • David D'Alessio, MD
  • Professor of Medicine
  • Academic Office:
    UC Medical Center Stetson Center
    3260 Stetson Street, Ste. 4200, ML 0547
    Cincinnati, OH 45219-0547
  • Clinical Office:
    UC Health Physicans Office - Clifton
    222 Piedmont, Ste 6300
    Cincinnati, OH 45219
  • Phone: 513-558-4444
  • Email: dalessd@ucmail.uc.edu

    Research/Clinical Interests:

  • Regulation of Insulin Secretion in Diabetes by Hormones and Neural Signals, Metabolic Effects of Glucagon-like Peptide 1, Control of Food Intake by Intestinal Hormones, Mechanisms of Action for Bariatric Surgery.

    Education/Credentials:

  • Bachelor's Degree: Carleton College, 1979
  • Medical Degree: University of Wisconsin, 1983
  • Residency: Temple University Hospital , 1986
  • Research Associate : Temple University , 1987
  • Research Fellowship: University of Washington , 1990

Board Certifications & Licenses:

  • Pennsylvania, 1983
  • Washington, 1987
  • Ohio, 1999
  • Diplomate, American Board of Internal Medicine, 1987
  • Diplomate, American Subspecialty Board, Endocrinology & Metabolism, 1990

Peer Reviewed Publications (in chronological order):

  • Liu, M., Shen, L., Begg, D. P., D'alessio, D. A., & Woods, S. C. (2012). Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats. . Journal of Neuroscience Methods , 209 (1) , 106-12.
  • Mul, J. D., Begg, D. P., Alsters, S. I. M., Haaften, G. v., Duran, K. J., D'Alessio, D. A., le Roux, C. W., Woods, S. C., Sandoval, D. A., Blakemore, A. I. F., Cuppen, E., van Haelst, M. M., & Seeley, R. J. (2012). Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. . American Journal of Physiology. Endocrinology and Metabolism , 303 (1) , E103-10.
  • Salehi, M., Aulinger, B., & D'Alessio, D. A. (2012). Effect of Glycemia on Plasma Incretins and the Incretin Effect During Oral Glucose Tolerance Test. . Diabetes.
  • Elder, D. A., Herbers, P. M., Weis, T., Standiford, D., Woo, J. G., & D'Alessio, D. A. (2012). ?-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus. . The Journal of Pediatrics , 160 (6) , 904-10.
  • Rebholz, S. L., Jones, T., Burke, K. T., Jaeschke, A., Tso, P., D'Alessio, D. A., & Woollett, L. A. (2012). Multiparity leads to obesity and inflammation in mothers and obesity in male offspring. . American Journal of Physiology. Endocrinology and Metabolism , 302 (4) , E449-57.
  • Chambers, A. P., Stefater, M. A., Wilson-Perez, H. E., Jessen, L., Sisley, S., Ryan, K. K., Gaitonde, S., Sorrell, J. E., Toure, M., Berger, J., D'Alessio, D. A., Sandoval, D. A., Seeley, R. J., & Woods, S. C. (2011). Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. . Physiology & Behavior , 105 (1) , 120-3.
  • Summer, S. S., Brehm, B. J., Benoit, S. C., & D'Alessio, D. A. (2011). Adiponectin changes in relation to the macronutrient composition of a weight-loss diet. . Obesity (Silver Spring, Md.) , 19 (11) , 2198-204.
  • Salehi, M., Prigeon, R. L., & D'Alessio, D. A. (2011). Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans. . Diabetes , 60 (9) , 2308-14.
  • Chambers, A. P., Jessen, L., Ryan, K. K., Sisley, S., Wilson-Pérez, H. E., Stefater, M. A., Gaitonde, S. G., Sorrell, J. E., Toure, M., Berger, J., D'Alessio, D. A., Woods, S. C., Seeley, R. J., & Sandoval, D. A. (2011). Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. . Gastroenterology , 141 (3) , 950-8.
  • D'Alessio, David A (2011). What if gut hormones aren't really hormones: DPP-4 inhibition and local action of GLP-1 in the gastrointestinal tract. . Endocrinology , 152 (8) , 2925-6.
  • Barrera, J. G., Sandoval, D. A., D'Alessio, D. A., & Seeley, R. J. (2011). GLP-1 and energy balance: an integrated model of short-term and long-term control. . Nature Reviews. Endocrinology , 7 (9) , 507-16.
  • Barrera, J. G., Jones, K. R., Herman, J. P., D'Alessio, D. A., Woods, S. C., & Seeley, R. J. (2011). Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 31 (10) , 3904-13.
  • Kindel, T. L., Martins, P. J. F., Yoder, S. M., Jandacek, R. J., Seeley, R. J., D'Alessio, D. A., Obici, S., & Tso, P. (2011). Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents. . Obesity (Silver Spring, Md.) , 19 (2) , 380-7.
  • Zhang, R., Jankord, R., Flak, J. N., Solomon, M. B., D'Alessio, D. A., & Herman, J. P. (2010). Role of glucocorticoids in tuning hindbrain stress integration. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 30 (44) , 14907-14.
  • Kohli, R., Kirby, M., Setchell, K. D. R., Jha, P., Klustaitis, K., Woollett, L. A., Pfluger, P. T., Balistreri, W. F., Tso, P., Jandacek, R. J., Woods, S. C., Heubi, J. E., Tschoep, M. H., D'Alessio, D. A., Shroyer, N. F., & Seeley, R. J. (2010). Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 299 (3) , G652-60.
  • Elder, D. A., Woo, J. G., & D'Alessio, D. A. (2010). Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. . Pediatric Diabetes , 11 (5) , 314-21.
  • Lê, K., D'Alessio, D. A., & Tappy, L. (2010). Metabolic effects of excess energy intake: does food composition matter? . Current Opinion in Clinical Nutrition and Metabolic Care , 13 (4) , 429-31.
  • D'Alessio, David A (2010). Taking aim at islet hormones with GLP-1: is insulin or glucagon the better target? . Diabetes , 59 (7) , 1572-4.
  • Diab, D. L., & D'Alessio, D. A. (2010). The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus. . Current Diabetes Reports , 10 (3) , 192-8.
  • Salehi, M., Aulinger, B., Prigeon, R. L., & D'Alessio, D. A. (2010). Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes. . Diabetes , 59 (6) , 1330-7.
  • Kindel, T. L., Yoder, S. M., D'Alessio, D. A., & Tso, P. (2010). The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats. . Obesity Surgery , 20 (6) , 768-75.
  • Pérez-Tilve, D., González-Matías, L., Aulinger, B. A., Alvarez-Crespo, M., Gil-Lozano, M., Alvarez, E., Andrade-Olivie, A. M., Tschöp, M. H., D'Alessio, D. A., & Mallo, F. (2010). Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system. . American Journal of Physiology. Endocrinology and Metabolism , 298 (5) , E1088-96.
  • Vahl, T. P., Drazen, D. L., Seeley, R. J., D'Alessio, D. A., & Woods, S. C. (2010). Meal-anticipatory glucagon-like peptide-1 secretion in rats. . Endocrinology , 151 (2) , 569-75.
  • Falciglia, M., Freyberg, R. W., Almenoff, P. L., D'Alessio, D. A., & Render, M. L. (2009). Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. . Critical Care Medicine , 37 (12) , 3001-9.
  • Barrera, J. G., D'Alessio, D. A., Drucker, D. J., Woods, S. C., & Seeley, R. J. (2009). Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. . Diabetes , 58 (12) , 2820-7.
  • Kindel, T. L., Yoder, S. M., Seeley, R. J., D'Alessio, D. A., & Tso, P. (2009). Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. . Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract , 13 (10) , 1762-72.
  • Cota, D., Sandoval, D. A., Olivieri, M., Prodi, E., D'Alessio, D. A., Woods, S. C., Seeley, R. J., & Obici, S. (2009). Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. . Obesity (Silver Spring, Md.) , 17 (8) , 1641-5.
  • Kim, D., D'Alessio, D. A., Woods, S. C., & Seeley, R. J. (2009). The effects of GLP-1 infusion in the hepatic portal region on food intake. . Regulatory Peptides , 155 (1-3) , 110-4.
  • Zhang, R., Packard, B. A., Tauchi, M., D'Alessio, D. A., & Herman, J. P. (2009). Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress. . Proceedings of the National Academy of Sciences of the United States of America , 106 (14) , 5913-8.
  • Brehm, B. J., Lattin, B. L., Summer, S. S., Boback, J. A., Gilchrist, G. M., Jandacek, R. J., & D'Alessio, D. A. (2009). One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes. . Diabetes Care , 32 (2) , 215-20.
  • Shertzer, H. G., Schneider, S. N., Kendig, E. L., Clegg, D. J., D'Alessio, D. A., Johansson, E., & Genter, M. B. (2009). Tetrahydroindenoindole inhibits the progression of diabetes in mice. . Chemico-biological Interactions , 177 (1) , 71-80.
  • D'Alessio, D. A., Denney, A. M., Hermiller, L. M., Prigeon, R. L., Martin, J. M., Tharp, W. G., Saylan, M. L., He, Y., Dunning, B. E., Foley, J. E., & Pratley, R. E. (2009). Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes. . The Journal of Clinical Endocrinology and Metabolism , 94 (1) , 81-8.
  • Tauchi, M., Zhang, R., D'Alessio, D. A., Stern, J. E., & Herman, J. P. (2008). Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei. . Journal of Chemical Neuroanatomy , 36 (3-4) , 144-9.
  • Salehi, M., Vahl, T. P., & D'Alessio, D. A. (2008). Regulation of islet hormone release and gastric emptying by endogenous glucagon-like peptide 1 after glucose ingestion. . The Journal of Clinical Endocrinology and Metabolism , 93 (12) , 4909-16.
  • Woods, S. C., & D'Alessio, D. A. (2008). Central control of body weight and appetite. . The Journal of Clinical Endocrinology and Metabolism , 93 (11 Suppl 1) , S37-50.
  • Brehm, B. J., & D'Alessio, D. A. (2008). Benefits of high-protein weight loss diets: enough evidence for practice? . Current Opinion in Endocrinology, Diabetes, and Obesity , 15 (5) , 416-21.
  • Perez-Tilve, D., D'Alessio, D. A., & Tschöp, M. H. (2008). A sweet spot for the bariatric surgeon. . Cell Metabolism , 8 (3) , 177-9.
  • Sandoval, D. A., Bagnol, D., Woods, S. C., D'Alessio, D. A., & Seeley, R. J. (2008). Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. . Diabetes , 57 (8) , 2046-54.
  • Elder, D. A., D'Alessio, D. A., Eyal, O., Mueller, R., Smith, F. O., Kansra, A. R., & Rose, S. R. (2008). Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion. . Pediatric Blood & Cancer , 51 (2) , 256-60.
  • Strawn, J. R., D'Alessio, D. A., Keck, P. E., & Seeley, R. J. (2008). Failure of glucagon-like peptide-1 to induce panic attacks or anxiety in patients with panic disorder. . Journal of Psychiatric Research , 42 (9) , 787-9.
  • Salehi, M., Aulinger, B. A., & D'Alessio, D. A. (2008). Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins. . Endocrine Reviews , 29 (3) , 367-79.
  • Reed, J. A., Benoit, S. C., Pfluger, P. T., Tschöp, M. H., D'Alessio, D. A., & Seeley, R. J. (2008). Mice with chronically increased circulating ghrelin develop age-related glucose intolerance. . American Journal of Physiology. Endocrinology and Metabolism , 294 (4) , E752-60.
  • Tauchi, M., Zhang, R., D'Alessio, D. A., Seeley, R. J., & Herman, J. P. (2008). Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress. . Experimental Neurology , 210 (2) , 458-66.
  • Gray, D. L., O'Brien, K. D., D'Alessio, D. A., Brehm, B. J., & Deeg, M. A. (2008). Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women. . Metabolism: Clinical and Experimental , 57 (4) , 473-8.
  • Kemp, C. J., D'Alessio, D. A., Scott, R. O., Kelm, G. R., Meller, S. T., Barrera, J. G., Seeley, R. J., Clegg, D. J., & Benoit, S. C. (2008). Voluntary consumption of ethyl oleate reduces food intake and body weight in rats. . Physiology & Behavior , 93 (4-5) , 912-8.
  • Shertzer, H. G., Schneider, S. N., Kendig, E. L., Clegg, D. J., D'Alessio, D. A., & Genter, M. B. (2008). Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. . Biochemical Pharmacology , 75 (6) , 1402-10.
  • Brehm, B. J., & D'Alessio, D. A. (2008). Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff. . Nature Clinical Practice. Endocrinology & Metabolism , 4 (3) , 140-6.
  • Rodieux, F., Giusti, V., D'Alessio, D. A., Suter, M., & Tappy, L. (2008). Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. . Obesity (Silver Spring, Md.) , 16 (2) , 298-305.
  • Elder, D. A., Wooldridge, J. L., Dolan, L. M., & D'Alessio, D. A. (2007). Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes. . The Journal of Pediatrics , 151 (6) , 653-8.
  • Vahl, T. P., Tauchi, M., Durler, T. S., Elfers, E. E., Fernandes, T. M., Bitner, R. D., Ellis, K. S., Woods, S. C., Seeley, R. J., Herman, J. P., & D'Alessio, D. A. (2007). Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. . Endocrinology , 148 (10) , 4965-73.
  • Lê, K., Tappy, L., & D'Alessio, D. A. (2007). Mitochondrial dysfunction and insulin resistance: a matter of lifestyle? . Current Opinion in Clinical Nutrition and Metabolic Care , 10 (4) , 494-7.
  • Pfluger, P. T., Kampe, J., Castaneda, T. R., Vahl, T., D'Alessio, D. A., Kruthaupt, T., Benoit, S. C., Cuntz, U., Rochlitz, H. J., Moehlig, M., Pfeiffer, A. F. H., Koebnick, C., Weickert, M. O., Otto, B., Spranger, J., & Tschöp, M. H. (2007). Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. . The Journal of Clinical Endocrinology and Metabolism , 92 (2) , 583-8.
  • McElroy, S. L., Kotwal, R., Guerdjikova, A. I., Welge, J. A., Nelson, E. B., Lake, K. A., D'Alessio, D. A., Keck, P. E., & Hudson, J. I. (2006). Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial. . The Journal of Clinical Psychiatry , 67 (12) , 1897-906.
  • Watts, N. B., & D'Alessio, D. A. (2006). Type 2 diabetes, thiazolidinediones: bad to the bone? . The Journal of Clinical Endocrinology and Metabolism , 91 (9) , 3276-8.
  • Salehi, M., & D'Alessio, D. A. (2006). New therapies for type 2 diabetes based on glucagon-like peptide 1. . Cleveland Clinic Journal of Medicine , 73 (4) , 382-9.
  • Drazen, D. L., Vahl, T. P., D'Alessio, D. A., Seeley, R. J., & Woods, S. C. (2006). Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. . Endocrinology , 147 (1) , 23-30.
  • Elder, D. A., Prigeon, R. L., Wadwa, R. P., Dolan, L. M., & D'Alessio, D. A. (2006). Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults. . The Journal of Clinical Endocrinology and Metabolism , 91 (1) , 185-91.
  • D'Alessio, D. A., Sandoval, D. A., & Seeley, R. J. (2005). New ways in which GLP-1 can regulate glucose homeostasis. . The Journal of Clinical Investigation , 115 (12) , 3406-8.
  • Vahl, T. P., Ulrich-Lai, Y. M., Ostrander, M. M., Dolgas, C. M., Elfers, E. E., Seeley, R. J., D'Alessio, D. A., & Herman, J. P. (2005). Comparative analysis of ACTH and corticosterone sampling methods in rats. . American Journal of Physiology. Endocrinology and Metabolism , 289 (5) , E823-8.
  • D'Alessio, D. A., & Vahl, T. P. (2005). Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches. . Current Diabetes Reports , 5 (5) , 346-52.
  • Proulx, K., Cota, D., Castañeda, T. R., Tschöp, M. H., D'Alessio, D. A., Tso, P., Woods, S. C., & Seeley, R. J. (2005). Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology , 289 (3) , R729-37.
  • D'Alessio, D. A., Lê, K., & Tappy, L. (2005). Type 2 diabetes and insulin resistance: an hepatocentric phenomenon? . Current Opinion in Clinical Nutrition and Metabolic Care , 8 (4) , 428-30.
  • Qin, X., Shen, H., Liu, M., Yang, Q., Zheng, S., Sabo, M., D'Alessio, D. A., & Tso, P. (2005). GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 288 (5) , G943-9.
  • O'Brien, K. D., Brehm, B. J., Seeley, R. J., Bean, J., Wener, M. H., Daniels, S., & D'Alessio, D. A. (2005). Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects. . The Journal of Clinical Endocrinology and Metabolism , 90 (4) , 2244-9.
  • Brehm, B. J., Spang, S. E., Lattin, B. L., Seeley, R. J., Daniels, S. R., & D'Alessio, D. A. (2005). The role of energy expenditure in the differential weight loss in obese women on low-fat and low-carbohydrate diets. . The Journal of Clinical Endocrinology and Metabolism , 90 (3) , 1475-82.
  • Strader, A. D., Vahl, T. P., Jandacek, R. J., Woods, S. C., D'Alessio, D. A., & Seeley, R. J. (2005). Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats. . American Journal of Physiology. Endocrinology and Metabolism , 288 (2) , E447-53.
  • Lachey, J. L., D'Alessio, D. A., Rinaman, L., Elmquist, J. K., Drucker, D. J., & Seeley, R. J. (2005). The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. . Endocrinology , 146 (1) , 458-62.
  • Wray, C. J., Ahmad, S. A., Lowy, A. M., D'Alessio, D. A., Gelrud, A., Choe, K. A., Soldano, D. A., Matthews, J. B., & Rodriguez-Rilo, H. L. (2005). Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions. . Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.] , 5 (6) , 562-9.
  • Woods, S. C., D'Alessio, D. A., Tso, P., Rushing, P. A., Clegg, D. J., Benoit, S. C., Gotoh, K., Liu, M., & Seeley, R. J. (2004). Consumption of a high-fat diet alters the homeostatic regulation of energy balance. . Physiology & Behavior , 83 (4) , 573-8.
  • D'Alessio, D. A., & Vahl, T. P. (2004). Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes. . American Journal of Physiology. Endocrinology and Metabolism , 286 (6) , E882-90.
  • Seeley, R. J., D'Alessio, D. A., & Woods, S. C. (2004). Fat hormones pull their weight in the CNS. . Nature Medicine , 10 (5) , 454-5.
  • Vahl, T. P., & D'Alessio, D. A. (2004). Gut peptides in the treatment of diabetes mellitus. . Expert Opinion on Investigational Drugs , 13 (3) , 177-88.
  • Prigeon, R. L., Quddusi, S., Paty, B., & D'Alessio, D. A. (2003). Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect. . American Journal of Physiology. Endocrinology and Metabolism , 285 (4) , E701-7.
  • Ehlers, M. R., Klaff, L. J., D'Alessio, D. A., Brazg, R., Kay, H. D., Harley, R. E., Mathisen, A. L., & Schneider, R. (2003). Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes. . Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et M & #233;tabolisme , 35 (10) , 611-6.
  • Ensinck, J. W., Laschansky, E. C., Vogel, R. E., & D'Alessio, D. A. (2003). Effect of ingested nutrients on the release of thrittene into the human circulation. . The Journal of Clinical Endocrinology and Metabolism , 88 (10) , 4798-804.
  • Henchoz, E., D'Alessio, D. A., Gillet, M., Halkic, N., Matzinger, O., Goy, J., Chioléro, R., Tappy, L., & Schneiter, P. (2003). Impaired insulin response after oral but not intravenous glucose in heart- and liver-transplant recipients. . Transplantation , 76 (6) , 923-9.
  • Kinzig, K. P., D'Alessio, D. A., Herman, J. P., Sakai, R. R., Vahl, T. P., Figueiredo, H. F., Murphy, E. K., Seeley, R. J., & Figueredo, H. F. (2003). CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 23 (15) , 6163-70.
  • Vahl, T. P., Paty, B. W., Fuller, B. D., Prigeon, R. L., & D'Alessio, D. A. (2003). Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. . The Journal of Clinical Endocrinology and Metabolism , 88 (4) , 1772-9.
  • Brehm, B. J., Seeley, R. J., Daniels, S. R., & D'Alessio, D. A. (2003). A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. . The Journal of Clinical Endocrinology and Metabolism , 88 (4) , 1617-23.
  • Quddusi, S., Vahl, T. P., Hanson, K., Prigeon, R. L., & D'Alessio, D. A. (2003). Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans. . Diabetes Care , 26 (3) , 791-8.
  • Kinzig, K. P., D'Alessio, D. A., & Seeley, R. J. (2002). The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 22 (23) , 10470-6.
  • Ensinck, J. W., Baskin, D. G., Vahl, T. P., Vogel, R. E., Laschansky, E. C., Francis, B. H., Hoffman, R. C., Krakover, J. D., Stamm, M. R., Low, M. J., Rubinstein, M., Otero-Corchon, V., & D'Alessio, D. A. (2002). Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation. . Endocrinology , 143 (7) , 2599-609.
  • Greenbaum, C. J., Prigeon, R. L., & D'Alessio, D. A. (2002). Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose. . Diabetes , 51 (4) , 951-7.
  • Tamashiro, K. L. K., Wakayama, T., Akutsu, H., Yamazaki, Y., Lachey, J. L., Wortman, M. D., Seeley, R. J., D'Alessio, D. A., Woods, S. C., Yanagimachi, R., & Sakai, R. R. (2002). Cloned mice have an obese phenotype not transmitted to their offspring. . Nature Medicine , 8 (3) , 262-7.
  • Rushing, P. A., Hagan, M. M., Seeley, R. J., Lutz, T. A., D'Alessio, D. A., Air, E. L., & Woods, S. C. (2001). Inhibition of central amylin signaling increases food intake and body adiposity in rats. . Endocrinology , 142 (11) , 5035.
  • D'Alessio, D. A., Kieffer, T. J., Taborsky, G. J., & Havel, P. J. (2001). Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. . The Journal of Clinical Endocrinology and Metabolism , 86 (3) , 1253-9.
  • Verchere, C. B., D'Alessio, D. A., Prigeon, R. L., Hull, R. L., & Kahn, S. E. (2000). The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells. . Diabetes , 49 (9) , 1477-84.
  • Owen, O. E., Smalley, K. J., D'Alessio, D. A., Mozzoli, M. A., & Dawson, E. K. (1998). Protein, fat, and carbohydrate requirements during starvation: anaplerosis and cataplerosis. . The American Journal of Clinical Nutrition , 68 (1) , 12-34.
  • Ensinck, J. W., Vogel, R. E., Laschansky, E. C., Koerker, D. J., Prigeon, R. L., Kahn, S. E., & D'Alessio, D. A. (1997). Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons. . The Journal of Clinical Investigation , 100 (9) , 2295-302.
  • Verchere, C. B., D'Alessio, D. A., Wang, S., Andrikopoulos, S., & Kahn, S. E. (1997). Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation. . Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et M & #233;tabolisme , 29 (6) , 311-6.
  • Verchere, C. B., D'Alessio, D. A., Palmiter, R. D., Weir, G. C., Bonner-Weir, S., Baskin, D. G., & Kahn, S. E. (1996). Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. . Proceedings of the National Academy of Sciences of the United States of America , 93 (8) , 3492-6.
  • D'Alessio, D. A., Vogel, R., Prigeon, R., Laschansky, E., Koerker, D., Eng, J., & Ensinck, J. W. (1996). Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons. . The Journal of Clinical Investigation , 97 (1) , 133-8.
  • D'Alessio, D. A., Prigeon, R. L., & Ensinck, J. W. (1995). Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I. . Diabetes , 44 (12) , 1433-7.
  • D'Alessio, D. A., Verchere, C. B., Kahn, S. E., Hoagland, V., Baskin, D. G., Palmiter, R. D., & Ensinck, J. W. (1994). Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse. . Diabetes , 43 (12) , 1457-61.
  • Verchere, C. B., D'Alessio, D. A., Palmiter, R. D., & Kahn, S. E. (1994). Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro. . Diabetologia , 37 (7) , 725-8.
  • D'Alessio, D. A., Kahn, S. E., Leusner, C. R., & Ensinck, J. W. (1994). Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. . The Journal of Clinical Investigation , 93 (5) , 2263-6.
  • Baskin, D. G., Schwartz, M. W., Sipols, A. J., D'Alessio, D. A., Goldstein, B. J., & White, M. F. (1994). Insulin receptor substrate-1 (IRS-1) expression in rat brain. . Endocrinology , 134 (4) , 1952-5.
  • Kahn, S. E., Verchere, C. B., D'Alessio, D. A., Cook, D. L., & Fujimoto, W. Y. (1993). Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway. . Diabetologia , 36 (6) , 570-3.
  • Boswell, T., Richardson, R. D., Schwartz, M. W., D'Alessio, D. A., Woods, S. C., Sipols, A. J., Baskin, D. G., & Kenagy, G. J. (1993). NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding. . Brain Research Bulletin , 32 (4) , 379-84.
  • Ensinck, J. W., & D'Alessio, D. A. (1992). The enteroinsular axis revisited. A novel role for an incretin. . The New England Journal of Medicine , 326 (20) , 1352-3.
  • Owen, O. E., Mozzoli, M. A., Smalley, K. J., Kavle, E. C., & D'Alessio, D. A. (1992). Oxidative and nonoxidative macronutrient disposal in lean and obese men after mixed meals. . The American Journal of Clinical Nutrition , 55 (3) , 630-6.
  • Kahn, S. E., Fujimoto, W. Y., D'Alessio, D. A., Ensinck, J. W., & Porte, D. (1991). Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell. . Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et M & #233;tabolisme , 23 (12) , 577-80.
  • Ensinck, J. W., Laschansky, E. C., Vogel, R. E., & D'Alessio, D. A. (1991). Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas. . Diabetes , 40 (9) , 1163-9.
  • D'Alessio, D. A., & Ensinck, J. W. (1990). Fasting and postprandial concentrations of somatostatin-28 and somatostatin-14 in type II diabetes in men. . Diabetes , 39 (10) , 1198-202.
  • Kahn, S. E., D'Alessio, D. A., Schwartz, M. W., Fujimoto, W. Y., Ensinck, J. W., Taborsky, G. J., & Porte, D. (1990). Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells. . Diabetes , 39 (5) , 634-8.
  • Owen, O. E., Smalley, K. J., D'Alessio, D. A., Mozzoli, M. A., Knerr, A. N., Kendrick, Z. V., Kavle, E. C., Donohoe, M., Tappy, L., & Boden, G. (1990). Resting metabolic rate and body composition of achondroplastic dwarfs. . Medicine , 69 (1) , 56-67.
  • D'Alessio, D. A., Fujimoto, W. Y., & Ensinck, J. W. (1989). Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures. . Diabetes , 38 (12) , 1534-8.
  • D'Alessio, D. A., Sieber, C., Beglinger, C., & Ensinck, J. W. (1989). A physiologic role for somatostatin 28 as a regulator of insulin secretion. . The Journal of Clinical Investigation , 84 (3) , 857-62.
  • D'Alessio, D. A., Kavle, E. C., Mozzoli, M. A., Smalley, K. J., Polansky, M., Kendrick, Z. V., Owen, L. R., Bushman, M. C., Boden, G., & Owen, O. E. (1988). Thermic effect of food in lean and obese men. . The Journal of Clinical Investigation , 81 (6) , 1781-9.
  • Owen, O. E., Holup, J. L., D'Alessio, D. A., Craig, E. S., Polansky, M., Smalley, K. J., Kavle, E. C., Bushman, M. C., Owen, L. R., & Mozzoli, M. A. (1987). A reappraisal of the caloric requirements of men. . The American Journal of Clinical Nutrition , 46 (6) , 875-85.
  • Brehm, B. J., Gates, D. M., Singler, M., Succop, P. A., & D'Alessio, D. A. Environmental changes to control obesity: a randomized controlled trial in manufacturing companies. . American Journal of Health Promotion : AJHP , 25 (5) , 334-40.

    Research Grants:

  • R01 DK54890 NIH/NIDDK. CNS-GLP-1: Multiple roles in ingestion and adiposity The aims of this project are to define the role of GLP-1 in the regulation of food intake., Co-Investigator
  • R01 DK57900 NIH/NIDDK. GLP-1 in normal and abnormal glucose tolerance The aims of this project are to determine the mechanisms by which GLP-1 regulates blood glucose, and to determine the contribution of GLP-1 to the incretin effect in diabetic and nondiabetic humans., P.I.
  • P01 DK 56863-01 NIH/NIDDK. Brain/Gut mechanisms in dietary obesity The aims of this project are to determine the regulatory mechanisms that are altered in diet-induced obesity., Co-Investigator
  • 1-U24-DK59630 NIH/NIDDK. Cincinnati Diabetes Phenotyping Center This center grant provides infrastructure for a center which will provide phenotyping services to NIH supported investigators with transgenic mice that may have diabetes related phenotypes. Dr. D'Alessio is Associate Director of the Physiology Core., Co-Investigator
  • American Diabetes Association. Regulation of beta-cell function in intrahepatic autotransplants The aims of this project are to study the factors regulating insulin secretion in animals and humans with intrahepatic islet transplants., PI
  • American Diabetes Association. A prospectie study of glucose tolerance in new onset psychotic and bipolar disorders The aims of this project are to determine the effects of antipsychotic medications on insulin secretion and insulin sensitivity in new onset schizophrenic patients., Co-Investigator
  • American Diabetes Association. A comparison of high monounsaturated fat and high carbohydrates diets on glycemic control and cardiovascular risk factors in Type II diabetes The aims of this project are to compare the two diets currently reccomended for patients with type 2 diabetes in free living subjects to determine their relative effects on glycemic and lipid parameters., Co-Investigator
  • GLP1 Eli Lilly and Company. Role of GLP-1 Signaling on Insulin Secretion and Islet Mass Following Intrahepatic, PI, Closed.
  • 3-R01-DK-57900-03-A0-S1-E0 National Inst of Diabetes and Digestive and Kidney Disease. GLP-1 in Normal and Abnormal Glucose Tolerance, PI, Closed.
  • R01 DK057900 National Inst of Diabetes and Digestive and Kidney Disease. The Role of GLP-1 in Normal and Abnormal Glucose Tolerance, PI, Closed.
  • 5-R01-DK-57900-03-A0-S0-E0 National Inst of Diabetes and Digestive and Kidney Disease. GLP-1 in Normal and Abnormal Glucose Tolerance, PI, Closed.
  • ADA-22-03-A0-S0-E0 American Diabetes Association. Secretion Metabolism and Action of Glucagon-Like Peptide 1 and Related Peptides in Healthy and Diabetic Humans, PI, Closed.
  • Procter & Gamble Company. Performance of Certain Tests to Obtain Numerial Data and/or Other Information, PI, Closed.
  • American Diabetes Association. Regulation and Adaptation of B-Cell function in Interahepatic Islet Auto-transplantation, PI, Closed.
  • CHMC 102730 / M01 RR08084 National Center for Research Resources. General Clinical Research Center, PI, Closed.
  • R01 DK054890 National Inst of Diabetes and Digestive and Kidney Disease. CNS GLP-1 Signaling in Energy and Glucose Homeostasis, Collaborator, Closed.
  • SRS 005156 University of Texas Southwestern Medical Center at Dallas. Hormone Measurement, PI, Closed.
  • SRS 005437 Ethicon Endo Surgery, Incorporated. New Therapeutic Strategies for Obesity, Collaborator, Active.
  • SRS 005924 Department of Veterans Affairs. Intergovernmental Personnel Act Agreement for Amanda Huber, PI, Closed.
  • 1-2009-293 Juvenile Diabetes Research Foundation International. Role of mTOR in the Enhancement of Beta-Cell Mass and Function, Collaborator, Closed.
  • K23 DK083554 National Inst of Diabetes and Digestive and Kidney Disease. Hormonal and Neural Control of Insulin Secretion Following Gastric Bypass Surgery, Collaborator, Active.
  • SRS 006299 Eli Lilly and Company. Mechanisms of Action of Exendin-4 and GLP-1 to Reduce Food-Intake and Regulate Body Weight, PI, Closed.
  • 2 R01 DK057900-08A1 National Inst of Diabetes and Digestive and Kidney Disease. The Role of GLP-1 in Normal and Abnormal Glucose Tolerance, PI, Active.
  • 0255-3631-4609 / 7 R01 DK073681-04 National Inst of Diabetes and Digestive and Kidney Disease. Thyroglobulin Peptide Presentation by HLA-DR in Thyroiditis, PI, Closed.
  • SRS 006766 MannKind Corporation. MoA of Technosphere GLP-1, Collaborator, Closed.
  • 20497-36 / U24 DK076169 National Inst of Diabetes and Digestive and Kidney Disease. Increased Risk for Diabetes and Obesity in Offspring of Multiparous Mice, Collaborator, Active.
  • SRS 007253 Pfizer, Inc.. Obesity Drug Target Identification, Collaborator, Closed.
  • U24 DK059630 National Inst of Diabetes and Digestive and Kidney Disease. Cincinnati Mouse Metabolic Phenotyping Center, Collaborator, Active.
  • R01 DK093848 National Inst of Diabetes and Digestive and Kidney Disease. Dissecting Mechanisms of GLP-1 Based Therapies for Type II Diabetes, Collaborator, Active.
  • U24 DK076169* National Inst of Diabetes and Digestive and Kidney Disease. Risk of Multi-generational Programming in Offspring of Multiparous Mice, Collaborator, Active.
  • 5007467-SERV \ R01DK076092 National Inst of Diabetes and Digestive and Kidney Disease. The Role of Vitamin D in Established Type 2 Diabetes, PI, Active.
  • R01 DK0097550 National Inst of Diabetes and Digestive and Kidney Disease. The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes., Collaborator, Active.
  • S-GRD1213-KR6 \ U01DK098246 National Inst of Diabetes and Digestive and Kidney Disease. The Glycemia Reduction Approaches for Diabetes: A Comparative Effectiveness Study, Collaborator, Active.
  • 008654 Givaudan Flavor Corporation. Validating taste receptor-GLP-1 interactions, Collaborator, Active.

Recent Awards/Honors:

  • Sol Sherry Award. Clinical Research, Temple Unviersity, 1987
  • National Research Service Award (NRSA). NIH, 1988,1980
  • Clinical Associate Physician. Clinical Research Center, University of Washington, 1990,1992
  • Diabetes Research Council Young Investigator Award. University of Washington, 1990,1992
  • Basic Science Research Grant. University of Washington, 1991
  • Clinical Nutrition Research Unit Young Investigator Award. University of Washington, 1992,1994
  • Clinical Investigator Development Award (K08), NIH, 1994,1998
  • Howard Hughes Medical Institute Research Resources Program Award. University of Washington, 1997
  • American Diabetes Association Clinical Research Award, 1998,2001
  • Western Society for Clinical Investigation. elected member, 1998
  • Paul Beeson Award for Clinical Teaching. University of Washington, 1998
  • Councilar-at-large, AFMR, 1998,2000
  • Secretary-treasurer, AFMR, 2000,to Present
  • Vontz Chair for Diabetes Research. University of Cincinnati, 2000
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