Department Directory

  • Zhongyun Dong, MD, PhD
  • Professor of Medicine
  • Academic Office:
    Vontz Center for Molecular Studies
    3125 Eden Avenue
    Cincinnati, OH 45267-0508
  • Phone: 513-558-2176
  • Email: Zhongyun.Dong@uc.edu

    Research/Clinical Interests:

  • Prostate Cancer, IFN-b Gene Therapy, Angiogenesis, PCNA inhibitor, Androgen receptor inhibitor, Androgen receptor

    Education/Credentials:

  • Medical Degree: Anhui Medical University, 1983
  • Master's Degree: Peking Union Medical College, 1986
  • Doctoral Degree: Peking Union Medical College, 1989
  • Fellowship: The University of Texas M.D. Anderson Cancer Center , 1991

Peer Reviewed Publications (in chronological order):

  • Yun, Y., Pixley, S., X. Cui, T., Dong, Z., Collins, B., Shanov, V., Ko, S., Pai1, D., Yarmolenko, S., Schulz, M. J., and J. Sankar (2012). Carbon Nanomaterials: From Therapeutics to Regenerative Medicine . Nanomedicine and Biotherapeutic Discovery , 2 , 1000104.
  • Tan, Z., Chen, P., Schneider, N., Glover, S., Cui, L., Torgue, J., Rixe, O., Spitz, H. B., an Dong, Z. (2012). Significant systemic therapeutic effects of high-LET immunoradiation by Pb-trastuzumab against prostatic tumors of androgen-independent human prostate cancer in mice . Int J. Oncol , 40 , 1881-1888.
  • Cui, L., Dillehay, K. L., Chen, W., Shen, D., Dong, Z., W. Li (2012). Association of the CYP1B1 Leu432Val polymorphism with the risk of prostate cancer: a meta-analysis . Mol Biol Reports , 39 , 7465-71.
  • Cui, L., Chen, P., Tan, Z., and Dong, Z. (2012). Hemostatic gelatin sponge is a superior matrix to Matrigel for estabishment of LNCaP human prostate cancer in nude mice . Prostate , DOI:10 (1002/) , pros. 22520.
  • Tan, Z., Wortman, M., Dillehay, K.L., Seibel, W., Evelyn, C. R., Smith, S. J., Malkas, L., Zheng, Y., Lu, S., and Dong, Z. (2012). Small molecule targeting of PCNA chromatin association inhibits tumor cell growth . Mol Pharmacol , 81 , 811-9.
  • Xue, D., Yun Y., Tan Z., Dong Z., and M. J. Schultz (2012). (In Press). In Vivo and In Vitro degradation behavior of magnesium alloys as biomaterials . J. Mat. Sci. Tech..
  • Oleksowicz, L., Jiu, Y., Bracken, R.B, Gaitonde, K., Burke, B., Succop, P., Levin, L., Dong, Z., and Lu,S. (2012). Secretory Phospholipase A2-lla is a Target Gene of the HER/HER2-Elicited Pathway and Potential Plasma Biomarket for Poor Prognosis of Prostate Cancer . Prostate , 72 , 1140-49.
  • Kupert, E., Anderson, M. Liu, Y., Succop, P., Levin, L., Wang, J., Wikenheisser-Brokamp, K., Chen, P., Ponney, S., Macdonald, T., Dong, Z., Starnes, S. and Lu, S. (2011). Plasma secretory phospholipase A2-lla as a potential biomarker for lung cancer in patients with solitary pulmonary nodules . BMC Cancer , 11 , 513.
  • Dong, Z., Liu, Y., Levin, L., Oleksowicz, L., Wang, J., & Lu, S. (2011). (In Press). Vav3 oncogene is involved in regulation of secretory phospholipase A2-IIa expression in prostate cancer. . Oncology Reports , 25 (6) , 1511-6.
  • Meng, Q., Peng, Z., Chen, L., Si, J., Dong, Z., & Xia, Y. (2010). (In Press). Nuclear Factor-?B modulates cellular glutathione and prevents oxidative stress in cancer cells. . Cancer Letters , 299 (1) , 45-53.
  • Lu, S., Tan, Z., Wortman, M., Lu, S., & Dong, Z. (2010). (In Press). Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide. . Cancer Letters , 298 (2) , 250-7.
  • Dong, Z., Liu, Y., Scott, K. F., Levin, L., Gaitonde, K., Bracken, R. B., Burke, B., Zhai, Q. J., Wang, J., Oleksowicz, L., & Lu, S. (2010). (In Press). Secretory phospholipase A2-IIa is involved in prostate cancer progression and may potentially serve as a biomarker for prostate cancer. . Carcinogenesis , 31 (11) , 1948-55.
  • Cho, H., Dong, Z., Pauletti, G. M., Zhang, J., Xu, H., Gu, H., Wang, L., Ewing, R. C., Huth, C., Wang, F., & Shi, D. (2010). (In Press). Fluorescent, superparamagnetic nanospheres for drug storage, targeting, and imaging: a multifunctional nanocarrier system for cancer diagnosis and treatment. . ACS Nano , 4 (9) , 5398-404.
  • Yun, Y., Dong, Z., Tan, Z., & Schulz, M. J. (2010). (In Press). Development of an electrode cell impedance method to measure osteoblast cell activity in magnesium-conditioned media. . Analytical and Bioanalytical Chemistry , 396 (8) , 3009-15.
  • Liu, Y., Wu, X., Dong, Z., & Lu, S. (2010). (In Press). The molecular mechanism of Vav3 oncogene on upregulation of androgen receptor activity in prostate cancer cells. . International Journal of Oncology , 36 (3) , 623-33.
  • Lu, S., Tan, Z., Wortman, M., Lu, S., & Dong, Z. (2010). (In Press). Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells. . International Journal of Oncology , 36 (2) , 459-67.
  • Liu, Y., Mo, J. Q., Hu, Q., Boivin, G., Levin, L., Lu, S., Yang, D., Dong, Z., & Lu, S. (2008). (In Press). Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer. . Cancer Research , 68 (15) , 6396-406.
  • Lee, K., Liu, Y., Mo, J. Q., Zhang, J., Dong, Z., & Lu, S. (2008). (In Press). Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. . BMC Cancer , 8 , 158.
  • Wang, D., Lu, S., & Dong, Z. (2007). (In Press). Regulation of TGF-beta1 gene transcription in human prostate cancer cells by nitric oxide. . The Prostate , 67 (16) , 1825-33.
  • Yun, Y., Dong, Z., Shanov, V. N., & Schulz, M. J. (2007). (In Press). Electrochemical impedance measurement of prostate cancer cells using carbon nanotube array electrodes in a microfluidic channel. . Nanotechnology , 18 (46) , 465505.
  • Lu, S., Lee, J., Revelo, M., Wang, X., Lu, S., & Dong, Z. (2007). (In Press). Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. . Clinical Cancer Research : An Official Journal of the American Association For Cancer Research , 13 (19) , 5692-702.
  • Yun, Y., Bange, A., Shanov, V. N., Heineman, W. R., Halsall, H. B., Dong, Z., Jazieh, A., Tu, Y., Wong, D., Pixley, S., Behbehani, M., & Schulz, M. J. (2007). (In Press). A carbon nanotube needle biosensor. . Journal of Nanoscience and Nanotechnology , 7 (7) , 2293-300.
  • Lu, S., Wang, A., Lu, S., & Dong, Z. (2007). (In Press). A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells. . Molecular Cancer Therapeutics , 6 (7) , 2057-64.
  • Yun, Y., Gollapudi, R., Shanov, V., Schulz, M. J., Dong, Z., Jazieh, A., Heineman, W. R., Halsall, H. B., Wong, D. K. Y., Bange, A., Tu, Y., & Subramaniam, S. (2007). (In Press). Carbon nanotubes grown on stainless steel to form plate and probe electrodes for chemical/biological sensing. . Journal of Nanoscience and Nanotechnology , 7 (3) , 891-7.
  • Lee, J., Wang, A., Hu, Q., Lu, S., & Dong, Z. (2006). (In Press). Adenovirus-mediated interferon-beta gene transfer inhibits angiogenesis in and progression of orthotopic tumors of human prostate cancer cells in nude mice. . International Journal of Oncology , 29 (6) , 1405-12.
  • Dong, Z., Liu, Y., Lu, S., Wang, A., Lee, K., Wang, L., Revelo, M., & Lu, S. (2006). (In Press). Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. . Molecular Endocrinology (Baltimore, Md.) , 20 (10) , 2315-25.
  • Lu, S., & Dong, Z. (2006). (In Press). Characterization of TGF-beta-regulated interleukin-8 expression in human prostate cancer cells. . The Prostate , 66 (9) , 996-1004.
  • Zhang, F., Lee, J., Wang, D., & Dong, Z. (2006). (In Press). Differential growth of IFN-beta-engineered tumor cells in nude and IFN receptor-null mice. . Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research , 26 (2) , 108-18.
  • Liu, G., Zhang, F., Lee, J., & Dong, Z. (2005). (In Press). Selective induction of interleukin-8 expression in metastatic melanoma cells by transforming growth factor-beta 1. . Cytokine , 31 (3) , 241-9.
  • Zhang, F., Lee, J., Lu, S., Pettaway, C. A., & Dong, Z. (2005). (In Press). Blockade of transforming growth factor-beta signaling suppresses progression of androgen-independent human prostate cancer in nude mice. . Clinical Cancer Research : An Official Journal of the American Association For Cancer Research , 11 (12) , 4512-20.
  • Uehara, H., Troncoso, P., Johnston, D., Bucana, C. D., Dinney, C., Dong, Z., Fidler, I. J., & Pettaway, C. A. (2005). (In Press). Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage. . The Prostate , 64 (1) , 40-9.
  • Ozawa, S., Lu, W., Bucana, C. D., Kanayama, H., Shinohara, H., Fidler, I. J., & Dong, Z. (2003). (In Press). Regression of primary murine colon cancer and occult liver metastasis by intralesional injection of lyophilized preparation of insect cells producing murine interferon-beta. . International Journal of Oncology , 22 (5) , 977-84.
  • Lu, W., Su, J., Kim, L. S., Bucana, C. D., Donawho, C., He, J., Fidler, I. J., & Dong, Z. (2003). (In Press). Active specific immunotherapy against occult brain metastasis. . Cancer Research , 63 (6) , 1345-50.
  • Harmey, J. H., Bucana, C. D., Lu, W., Byrne, A. M., McDonnell, S., Lynch, C., Bouchier-Hayes, D., & Dong, Z. (2002). (In Press). Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion. . International Journal of Cancer. Journal International Du Cancer , 101 (5) , 415-22.
  • Zhang, F., Lu, W., & Dong, Z. (2002). (In Press). Tumor-infiltrating macrophages are involved in suppressing growth and metastasis of human prostate cancer cells by INF-beta gene therapy in nude mice. . Clinical Cancer Research : An Official Journal of the American Association For Cancer Research , 8 (9) , 2942-51.
  • Lu, W., Dong, Z., Donawho, C., & Fidler, I. J. (2002). (In Press). Specific immunotherapy against occult cancer metastases. . International Journal of Cancer. Journal International Du Cancer , 100 (4) , 480-5.
  • Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R. L., & Akira, S. (2002). (In Press). Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. . Journal of Immunology (Baltimore, Md. : 1950) , 169 (1) , 10-4.
  • Makar, T. K., Wilt, S., Dong, Z., Fishman, P., Mouradian, M. M., & Dhib-Jalbut, S. (2002). (In Press). IFN-beta gene transfer into the central nervous system using bone marrow cells as a delivery system. . Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research , 22 (7) , 783-91.
  • Davies, M. A., Kim, S. J., Parikh, N. U., Dong, Z., Bucana, C. D., & Gallick, G. E. (2002). (In Press). Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells. . Clinical Cancer Research : An Official Journal of the American Association For Cancer Research , 8 (6) , 1904-14.
  • Izawa, J. I., Sweeney, P., Perrotte, P., Kedar, D., Dong, Z., Slaton, J. W., Karashima, T., Inoue, K., Benedict, W. F., & Dinney, C. P. N. (2002). (In Press). Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis. . Clinical Cancer Research : An Official Journal of the American Association For Cancer Research , 8 (4) , 1258-70.

    Research Grants:

  • NSF. A pilot microfactory for Nonomedicine devices - Grant, Co-PI, Active.
  • AREVA Med. In vivo Evaluation of a single intravenous injection of AREVA agent in PC-3 orthotopic tumor model The goal of this research is to investigate efficacy of a novel therapeutic compound in animal model., PI
  • NIH/NCI-R01. A novel androgen receptor antagonist The goal of this proposal is to investigate effects and mechanisms of a novel synthetic compound on androgen receptor signaling and to determine its effects on growth of prostate cancer in animal models., PI
  • NSF. Revolutionizing Metallic Biomaterials This is a multi-institution center grant proposal. The goal of this research is to develop magnesium alloy devices for medical applications., Co-I
  • Interdisciplinary Faculty Research Support - UC. Development of Luminescent Nanotubes for Cancer Diagnosis and Treatment, Co-PI
  • UC Cancer Center Pilot Grant. Development of Nanobiometric Sensor for detection of cytokines in cancers, PI
  • RSG-98-332-04 American Cancer Society - National Chapter. A Novel Therapy for Locally Advanced Prostate Cancer, PI, Closed.
  • R01 CA097099 National Cancer Institute. TGF-Beta 1-Regulated IL-8 Expression in Prostate Cancer, PI, Closed.
  • Department of Defense. A Novel Therapy System for Occult Protstae Cancer, PI, Closed.
  • R01 CA131137 National Cancer Institute. A Novel Synthetic Androgen Receptor Antagonist, PI, Active.
  • 260116B / EEC-0812348 National Science Foundation. Responsive Biosensors for Implants, Collaborator, Active.
  • SRS 006743 AREVA Med, LLC.. In Vivo Evaluation of a Single Intravenous Injection of AREVA Agent in PC-3 Orthotopic Tumor Model, Collaborator, Closed.
  • W81XWH-10-1-0367 Department of the Army Medical Research and Materiel Command. Targeted Delivery of Therapeutic RNA into Prostate Cancers, Collaborator, Active.
  • CBET-1239779 National Science Foundation. A Pilot Microfactory for Nanomedicine Devices, Collaborator, Active.
  • OBR Action Fund 994 Ohio Board of Regents. A Pilot Microfactory for Nanomedicine Devices, Collaborator, Active.

Recent Awards/Honors:

  • Science Advance Award. Chinese Academy of Medical Sciences, 1990
CARE/Crawley Building

More Information


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Phone: 513-558-4231
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