University of Cincinnati

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Peer Reviewed Publications (in chronological order):

• Perez-Tilve, D., Davidson, W. S., Tschöp, M., & Hofmann, S. M. (2011). (In Press). CNS regulation of plasma cholesterol. . Annals of Medicine.
• Perez-Tilve, D., Heppner, K., Kirchner, H., Lockie, S. H., Woods, S. C., Smiley, D. L., Tschöp, M., & Pfluger, P. (2011). (In Press). Ghrelin-induced adiposity is independent of orexigenic effects. . The FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology.
• Pfluger, P. T., Castañeda, T. R., Heppner, K. M., Strassburg, S., Kruthaupt, T., Chaudhary, N., Halem, H., Culler, M. D., Datta, R., Burget, L., Tschöp, M. H., Nogueiras, R., & Perez-Tilve, D. (2011). (In Press). Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. . Physiology & Behavior.
• Patterson, J. T., Ottaway, N., Gelfanov, V. M., Smiley, D. L., Perez-Tilve, D., Pfluger, P. T., Tschöp, M. H., & Dimarchi, R. D. (2011). (In Press). A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1. . ACS Chemical Biology , 6 (2) , 135-45.
• Müller, T. D., Perez-Tilve, D., Tong, J., Pfluger, P. T., & Tschöp, M. H. (2010). (In Press). Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia. . Journal of Cachexia, Sarcopenia and Muscle , 1 (2) , 159-167.
• Strassburg, S., Pfluger, P. T., Chaudhary, N., Tso, P., Tschöp, M. H., Anker, S. D., Nogueiras, R., & Perez-Tilve, D. (2010). (In Press). Action profile of the antiobesity drug candidate oleoyl-estrone in rats. . Obesity (Silver Spring, Md.) , 18 (12) , 2260-7.
• Horvath, T. L., Sarman, B., García-Cáceres, C., Enriori, P. J., Sotonyi, P., Shanabrough, M., Borok, E., Argente, J., Chowen, J. A., Perez-Tilve, D., Pfluger, P. T., Brönneke, H. S., Levin, B. E., Diano, S., Cowley, M. A., & Tschöp, M. H. (2010). (In Press). Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. . Proceedings of the National Academy of Sciences of the United States of America , 107 (33) , 14875-80.
• Heppner, K. M., Habegger, K. M., Day, J., Pfluger, P. T., Perez-Tilve, D., Ward, B., Gelfanov, V., Woods, S. C., DiMarchi, R., & Tschöp, M. (2010). (In Press). Glucagon regulation of energy metabolism. . Physiology & Behavior , 100 (5) , 545-8.
• Lee, S. J., Kim, J. Y., Nogueiras, R., Linares, J. F., Perez-Tilve, D., Jung, D. Y., Ko, H. J., Hofmann, S. M., Drew, A., Leitges, M., Kim, J. K., Tschöp, M. H., Diaz-Meco, M. T., & Moscat, J. (2010). (In Press). PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. . Cell Metabolism , 12 (1) , 65-77.
• Perez-Tilve, D., Hofmann, S. M., Basford, J., Nogueiras, R., Pfluger, P. T., Patterson, J. T., Grant, E., Wilson-Perez, H. E., Granholm, N. A., Arnold, M., Trevaskis, J. L., Butler, A. A., Davidson, W. S., Woods, S. C., Benoit, S. C., Sleeman, M. W., DiMarchi, R. D., Hui, D. Y., & Tschöp, M. H. (2010). (In Press). Melanocortin signaling in the CNS directly regulates circulating cholesterol. . Nature Neuroscience , 13 (7) , 877-82.
• Gil-Lozano, M., Pérez-Tilve, D., Alvarez-Crespo, M., Martís, A., Fernandez, A. M., Catalina, P. A. F., Gonzalez-Matias, L. C., & Mallo, F. (2010). (In Press). GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans. . Endocrinology , 151 (6) , 2629-40.
• Stefater, M. A., Pérez-Tilve, D., Chambers, A. P., Wilson-Pérez, H. E., Sandoval, D. A., Berger, J., Toure, M., Tschöp, M., Woods, S. C., & Seeley, R. J. (2010). (In Press). Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. . Gastroenterology , 138 (7) , 2426-36, 2436.e1-3.
• Pérez-Tilve, D., González-Matías, L., Aulinger, B. A., Alvarez-Crespo, M., Gil-Lozano, M., Alvarez, E., Andrade-Olivie, A. M., Tschöp, M. H., D'Alessio, D. A., & Mallo, F. (2010). (In Press). Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system. . American Journal of Physiology. Endocrinology and Metabolism , 298 (5) , E1088-96.
• Tschöp, J., Nogueiras, R., Haas-Lockie, S., Kasten, K. R., Castañeda, T. R., Huber, N., Guanciale, K., Perez-Tilve, D., Habegger, K., Ottaway, N., Woods, S. C., Oldfield, B., Clarke, I., Chua, S., Farooqi, I. S., O'Rahilly, S., Caldwell, C. C., & Tschöp, M. H. (2010). (In Press). CNS leptin action modulates immune response and survival in sepsis. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 30 (17) , 6036-47.
• Sutton, G. M., Begriche, K., Kumar, K. G., Gimble, J. M., Perez-Tilve, D., Nogueiras, R., McMillan, R. P., Hulver, M. W., Tschöp, M. H., & Butler, A. A. (2010). (In Press). Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. . The FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology , 24 (3) , 862-72.
• Day, J. W., Ottaway, N., Patterson, J. T., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., Holland, J., Hembree, J., Abplanalp, W., Grant, E., Ruehl, J., Wilson, H., Kirchner, H., Lockie, S. H., Hofmann, S., Woods, S. C., Nogueiras, R., Pfluger, P. T., Perez-Tilve, D., DiMarchi, R., & Tschöp, M. H. (2009). (In Press). A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. . Nature Chemical Biology , 5 (10) , 749-57.
• Nogueiras, R., Pérez-Tilve, D., Veyrat-Durebex, C., Morgan, D. A., Varela, L., Haynes, W. G., Patterson, J. T., Disse, E., Pfluger, P. T., López, M., Woods, S. C., DiMarchi, R., Diéguez, C., Rahmouni, K., Rohner-Jeanrenaud, F., & Tschöp, M. H. (2009). (In Press). Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 29 (18) , 5916-25.
• Sutton, G. M., Perez-Tilve, D., Nogueiras, R., Fang, J., Kim, J. K., Cone, R. D., Gimble, J. M., Tschöp, M. H., & Butler, A. A. (2008). (In Press). The melanocortin-3 receptor is required for entrainment to meal intake. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 28 (48) , 12946-55.
• Perez-Tilve, D., D'Alessio, D. A., & Tschöp, M. H. (2008). (In Press). A sweet spot for the bariatric surgeon. . Cell Metabolism , 8 (3) , 177-9.
• Strassburg, S., Anker, S. D., Castaneda, T. R., Burget, L., Perez-Tilve, D., Pfluger, P. T., Nogueiras, R., Halem, H., Dong, J. Z., Culler, M. D., Datta, R., & Tschöp, M. H. (2008). (In Press). Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. . American Journal of Physiology. Endocrinology and Metabolism , 295 (1) , E78-84.
• Nogueiras, R., López, M., Lage, R., Perez-Tilve, D., Pfluger, P., Mendieta-Zerón, H., Sakkou, M., Wiedmer, P., Benoit, S. C., Datta, R., Dong, J. Z., Culler, M., Sleeman, M., Vidal-Puig, A., Horvath, T., Treier, M., Diéguez, C., & Tschöp, M. H. (2008). (In Press). Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. . Endocrinology , 149 (6) , 3009-15.
• López, M., Lage, R., Saha, A. K., Pérez-Tilve, D., Vázquez, M. J., Varela, L., Sangiao-Alvarellos, S., Tovar, S., Raghay, K., Rodríguez-Cuenca, S., Deoliveira, R. M., Castañeda, T., Datta, R., Dong, J. Z., Culler, M., Sleeman, M. W., Alvarez, C. V., Gallego, R., Lelliott, C. J., Carling, D., Tschöp, M. H., Diéguez, C., & Vidal-Puig, A. (2008). (In Press). Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. . Cell Metabolism , 7 (5) , 389-99.
• Pfluger, P. T., Kirchner, H., Günnel, S., Schrott, B., Perez-Tilve, D., Fu, S., Benoit, S. C., Horvath, T., Joost, H., Wortley, K. E., Sleeman, M. W., & Tschöp, M. H. (2008). (In Press). Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 294 (3) , G610-8.
• Tizzano, J. P., Stribling, D. S., Perez-Tilve, D., Strack, A., Frassetto, A., Chen, R. Z., Fong, T. M., Shearman, L., Krieter, P. A., Tschöp, M. H., Skolnick, P., & Basile, A. S. (2008). (In Press). The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. . The Journal of Pharmacology and Experimental Therapeutics , 324 (3) , 1111-26.
• Hofmann, S. M., Perez-Tilve, D., Greer, T. M., Coburn, B. A., Grant, E., Basford, J. E., Tschöp, M. H., & Hui, D. Y. (2008). (In Press). Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. . Diabetes , 57 (1) , 5-12.
• Hofmann, S. M., Zhou, L., Perez-Tilve, D., Greer, T., Grant, E., Wancata, L., Thomas, A., Pfluger, P. T., Basford, J. E., Gilham, D., Herz, J., Tschöp, M. H., & Hui, D. Y. (2007). (In Press). Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. . The Journal of Clinical Investigation , 117 (11) , 3271-82.
• Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., Howles, P. N., Morgan, D. A., Benoit, S. C., Szanto, I., Schrott, B., Schürmann, A., Joost, H., Hammond, C., Hui, D. Y., Woods, S. C., Rahmouni, K., Butler, A. A., Farooqi, I. S., O'Rahilly, S., Rohner-Jeanrenaud, F., & Tschöp, M. H. (2007). (In Press). The central melanocortin system directly controls peripheral lipid metabolism. . The Journal of Clinical Investigation , 117 (11) , 3475-88.
• Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E. B., Jones, K. L., Kawamori, R., Cassis, L. A., Tschöp, M. H., & Bruemmer, D. (2007). (In Press). Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. . The Journal of Clinical Investigation , 117 (10) , 2877-88.
• Spuch, C., Diz-Chaves, Y., Pérez-Tilve, D., Alvarez-Crespo, M., & Mallo, F. (2007). (In Press). Prolactin-releasing Peptide (PrRP) increases prolactin responses to TRH in vitro and in vivo. . Endocrine , 31 (2) , 119-24.
• Pérez-Tilve, D., González-Matías, L., Alvarez-Crespo, M., Leiras, R., Tovar, S., Diéguez, C., & Mallo, F. (2007). (In Press). Exendin-4 potently decreases ghrelin levels in fasting rats. . Diabetes , 56 (1) , 143-51.
• Nogueiras, R., Pfluger, P., Tovar, S., Arnold, M., Mitchell, S., Morris, A., Perez-Tilve, D., Vázquez, M. J., Wiedmer, P., Castañeda, T. R., DiMarchi, R., Tschöp, M., Schurmann, A., Joost, H., Williams, L. M., Langhans, W., & Diéguez, C. (2007). (In Press). Effects of obestatin on energy balance and growth hormone secretion in rodents. . Endocrinology , 148 (1) , 21-6.
• Theander-Carrillo, C., Wiedmer, P., Cettour-Rose, P., Nogueiras, R., Perez-Tilve, D., Pfluger, P., Castaneda, T. R., Muzzin, P., Schürmann, A., Szanto, I., Tschöp, M. H., & Rohner-Jeanrenaud, F. (2006). (In Press). Ghrelin action in the brain controls adipocyte metabolism. . The Journal of Clinical Investigation , 116 (7) , 1983-93.
• Spuch, C., Diz-Chaves, Y., Pérez-Tilve, D., & Mallo, F. (2006). (In Press). Fibroblast growth factor-2 and epidermal growth factor modulate prolactin responses to TRH and dopamine in primary cultures. . Endocrine , 29 (2) , 317-24.
• Perez-Tilve, D., Stern, J. E., & Tschöp, M. (2006). (In Press). The brain and the metabolic syndrome: not a wireless connection. . Endocrinology , 147 (3) , 1136-9.
• Perez-Tilve, D., Nogueiras, R., Mallo, F., Benoit, S. C., & Tschoep, M. (2006). (In Press). Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism. . Endocrine , 29 (1) , 61-71.
• Spuch, C., Diz-Chaves, Y., Pérez-Tilve, D., & Mallo, F. (2004). (In Press). Heparin increases prolactin and modifies the effects of fgf-2 upon prolactin accumulation in pituitary primary cultures. . Endocrine , 24 (2) , 131-6.
• Diz Chaves, Y., Spuch Calvar, C., Pérez Tilve, D., & Mallo Ferrer, F. (2003). (In Press). GH responses to GHRH and GHRP-6 in Streptozotocin (STZ)-diabetic rats. . Life Sciences , 73 (26) , 3375-85.

Recent Awards/Honors:

• Predoctoral Fellowship. University of Vigo, Spain, 1999,2001
• Predoctoral Fellowship. Autonomic Government of Galicia, Spain, 2001,2004
• Postdoctoral Fellowship. Autonomic Government of Galicia and Spanish Ministry of Education and Science, Spain, 2004,2006

Positions and Work Experience

• 2009-to Present, Research Assistant Professor, Division of Endocrinology, Diabetes & Metabolism, Unviersity of Cincinanti College of Medicine, Cincinnati, OH