Department Directory

  • Diego Perez-Tilve, PhD
  • Research Assistant Professor of Endocrinology
  • Phone: 513-558-7700
  • Email: diego.pereztilve@uc.edu

    Education/Credentials:

  • Faculty of Sciences, University of Vigo1998
  • Doctoral Degree: University of Vigo, 2004
  • 2004 -2009 Postdoctoral Fellowship : Obesity Research Center and Genome Research Institute, University of Cincinnati , 2009

Peer Reviewed Publications (in chronological order):

  • Heppner, K. M., Piechowski, C. L., Muller, A.,D. A., and Perez-Tilve, D. Ottaway, N., Sisley, S., Smiley, D. L., Habegger, K. M., Pfluger, P. T., Dimarchi, R., Biebermann, H., Tschop, M. H., Sandoval, (2014). (In Press). Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. . Diabetes. (63) , 122-131.
  • Habegger, K. M., Heppner, K. M., Amburgy, S. E., Ottaway, N., Holland, J., Raver, C., Bartley, E., Muller, T. D., Pfluger, P. T., Berger, J., Toure, M., Benoit, S. C., Dimarchi, R. D., Perez-Tilve, D., D'Alessio, D. A., Seeley, R. J., and Tschop, M. H. (2014). (In Press). GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats. . Diabetes. (63) , 505-13.
  • Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., Garcia-Caceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschop, M. H., and Yi, C. X. (2014). (In Press). Hormones and diet, but not body weight, control hypothalamic microglial activity . Glia (62) , 17-25.
  • Habegger, K. M., Heppner, K. M., Amburgy, S. E., Ottaway, N., Holland, J., Raver, C., Bartley, E., Müller, T. D., Pfluger, P. T., Berger, J., Toure, M., Benoit, S. C., Dimarchi, R. D., Perez-Tilve, D., D'Alessio, D. A., Seeley, R. J., & Tschöp, M. H. (2014). GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. . Diabetes , 63 (2) , 505-13.
  • Heppner, K. M., Piechowski, C. L., Müller, A., Ottaway, N., Sisley, S., Smiley, D. L., Habegger, K. M., Pfluger, P. T., Dimarchi, R., Biebermann, H., Tschöp, M. H., Sandoval, D. A., & Perez-Tilve, D. (2014). Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. . Diabetes , 63 (1) , 122-31.
  • Gao, Y., Ottaway, N., Schriever, S. C., Legutko, B., García-Cáceres, C., de la Fuente, E., Mergen, C., Bour, S., Thaler, J. P., Seeley, R. J., Filosa, J., Stern, J. E., Perez-Tilve, D., Schwartz, M. W., Tschöp, M. H., & Yi, C. (2014). Hormones and diet, but not body weight, control hypothalamic microglial activity. . Glia , 62 (1) , 17-25.
  • Smith, E. P., An, Z., Wagner, C., Lewis, A. G., Cohen, E. B., Li, B., Mahbod, P., Sandoval, D., Perez-Tilve, D., Tamarina, N., Philipson, L. H., Stoffers, D. A., Seeley, R. J., & D'Alessio, D. A. (2014). The role of ? cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. . Cell Metabolism , 19 (6) , 1050-7.
  • Wilson-Perez, H. E., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D., Drucker, D. J., Perez-Tilve, D., and Seeley, R. J. (2013). (In Press). Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. . Diabetes. (62) , 2380-2385.
  • Ward, B. P., Ottaway, N. L., Perez-Tilve, D., Ma, D., Gelfanov, V. M., Tschop, M. H., and Dimarchi, R. D (2013). (In Press). Peptide lipidation stabilizes structure to enhance biological function. . Molecular Metabolism (2) , 468-479.
  • Muller, T. D., Muller, A., Yi, C. X., Habegger, K. M., Meyer, C. W., Gaylinn, B. D., Finan, B., Heppner, K., Trivedi, C., Bielohuby, M., Abplanalp, W., Meyer, F., Piechowski, C. L., Pratzka, J., Stemmer, K., Holland, J., Hembree, J., Bhardwaj, N., Raver, C., Ottaway, N., Krishna, R., Sah, R., Sallee, F. R., Woods, S. C., Perez-Tilve, D., Bidlingmaier, M., Thorner, M. O., Krude, H., Smiley, D., DiMarchi, R., Hofmann, S., Pfluger, P. T., Kleinau, G., Biebermann, H., and Tschop, M. H (2013). (In Press). The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms . Nature Communications (4) , 1968.
  • Muller, T. D., Lee, S. J., Jastroch, M., Kabra, D., Stemmer, K., Aichler, M., Abplanalp, B., Ananthakrishnan, G., Bhardwaj, N., Collins, S., Divanovic, S., Endele, M., Finan, B., Gao, Y., Habegger, K. M., Hembree, J., Heppner, K. M., Hofmann, S., Holland, J., Kuchler, D., Kutschke, M., Krishna, R., Lehti, M., Oelkrug, R., Ottaway, N., Perez-Tilve, D., Raver, C., Walch, A. K., Schriever, S. C., Speakman, J., Tseng, Y. H., Diaz-Meco, M., Pfluger, P. T., Moscat, J., and Tschop, M. H. (2013). (In Press). p62 links beta-adrenergic input to mitochondrial function and thermogenesis. . The Journal of Clinical Investigation (123) , 469-478.
  • Lim, C. T., Kola, B., Feltrin, D., Perez-Tilve, D., Tschop, M. H., Grossman, A. B., and Korbonits, M. (2013). (In Press). Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. . Molecular and Cellular Endocrinology (365) , 303-308.
  • Heppner, K. M., Muller, T. D., Kirchner, H., Perez-Tilve, D., Pfluger, P. T., Tschop, M. H., and Hofmann, S. M. (2013). (In Press). The role of ghrelin-octanoyl-acyl-transferase in thermoregulation . Journal of Endocrinological Investigation (36) , 180-184.
  • Habegger, K. M., Stemmer, K., Cheng, C., Muller, T. D., Heppner, K. M., Ottaway, N., Holland, J., Hembree, J. L., Smiley, D., Gelfanov, V., Krishna, R., Arafat, A. M., Konkar,A., Belli, S., Kapps, M., Woods, S. C., Hofmann, S. M., D, 039, Alessio, D., Pfluger, P. T., Perez-Tilve, D., Seeley, R. J., Konishi, M., Itoh, N., Kharitonenkov, A., Spranger, J., DiMarchi, R. D., & Tschop, M. H. (2013). (In Press). Fibroblast growth factor 21 mediates specific glucagon actions . Diabetes (62) , 1453-1463.
  • Habegger, K. M., Kirchner, H., Yi, C. X., Heppner, K. M., Sweeney, D., Ottaway, N., Holland, J., Amburgy, S., Raver, C., Krishna, R., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Obici, S., DiMarchi, R. D., D, 039, Alessio, D. A., Seeley, R. J., & Tschop, M. H. (2013). (In Press). GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. . Diabetes. (62) , 3261-3267.
  • Habegger, K. M., Al-Massadi, O., Heppner, K. M., Myronovych, A., Holland, J., Berger, J., Yi, C. X., Gao, Y., Lehti, M., Ottaway, N., Amburgy, S., Raver, C., Muller, T. D., Pfluger, P. T., Kohli, R., Perez-Tilve, D., Seeley, R. J., and Tschop, M. H. (2013). (In Press). Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. . Gut.
  • Gadang, V., Kohli, R., Myronovych, A., Hui, D. Y., Perez-Tilve, D., and Jaeschke, A. (2013). (In Press). MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. . American Journal of Physiology. Endocrinology and Metabolism ( 305) , 549-556.
  • Finan, B., Ma, T., Ottaway, N., Muller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., Lockie, S. H., Smiley, D. L., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D. J., Pfluger, P. T., Perez-Tilve, D., Gidda, J., Vignati, L., Zhang, L., Hauptman, J. B., Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, E., Sebokova, E., Conde-Knape, K., Konkar, A., DiMarchi, R. D., and Tschop, M. H. (2013). (In Press). Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. . Science Translational Medicine (5) , 209-151.
  • Habegger, K. M., Al-Massadi, O., Heppner, K. M., Myronovych, A., Holland, J., Berger, J., Yi, C., Gao, Y., Lehti, M., Ottaway, N., Amburgy, S., Raver, C., Müller, T. D., Pfluger, P. T., Kohli, R., Perez-Tilve, D., Seeley, R. J., & Tschöp, M. H. (2013). Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. . Gut.
  • Habegger, K. M., Kirchner, H., Yi, C., Heppner, K. M., Sweeney, D., Ottaway, N., Holland, J., Amburgy, S., Raver, C., Krishna, R., Müller, T. D., Perez-Tilve, D., Pfluger, P. T., Obici, S., DiMarchi, R. D., D'Alessio, D. A., Seeley, R. J., & Tschöp, M. H. (2013). GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats. . Diabetes , 62 (9) , 3261-7.
  • Gadang, V., Kohli, R., Myronovych, A., Hui, D. Y., Perez-Tilve, D., & Jaeschke, A. (2013). MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. . American Journal of Physiology. Endocrinology and Metabolism , 305 (4) , E549-56.
  • Wilson-Pérez, H. E., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D., Drucker, D. J., Pérez-Tilve, D., & Seeley, R. J. (2013). Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. . Diabetes , 62 (7) , 2380-5.
  • Habegger, K. M., Stemmer, K., Cheng, C., Müller, T. D., Heppner, K. M., Ottaway, N., Holland, J., Hembree, J. L., Smiley, D., Gelfanov, V., Krishna, R., Arafat, A. M., Konkar, A., Belli, S., Kapps, M., Woods, S. C., Hofmann, S. M., D'Alessio, D., Pfluger, P. T., Perez-Tilve, D., Seeley, R. J., Konishi, M., Itoh, N., Kharitonenkov, A., Spranger, J., DiMarchi, R. D., & Tschöp, M. H. (2013). Fibroblast growth factor 21 mediates specific glucagon actions. . Diabetes , 62 (5) , 1453-63.
  • Heppner, K. M., Müller, T. D., Kirchner, H., Perez-Tilve, D., Pfluger, P. T., Tschöp, M. H., & Hofmann, S. M. (2013). The role of ghrelin-octanoyl-acyl-transferase in thermoregulation. . Journal of Endocrinological Investigation , 36 (3) , 180-4.
  • Yi, C. X., Heppner, K. M., Kirchner, H., Tong, J., Bielohuby, M., Gaylinn, B. D., Muller, T. D., Bartley, E., Davis, H. W., Zhao, Y., Joseph, A., Kruthaupt, T., Ottaway, N., Kabra, D., Habegger, K. M., Benoit, S. C., Bidlingmaier, M., Thorner, M. O., Perez-Tilve, D., Tschop, M. H., and Pfluger, P. T. (2012). (In Press). The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. . PLoS ONE , 7 , 321.
  • Wiedmer, P., Chaudhary, N., Rath, M., Yi, C. X., Ananthakrishnan, G., Nogueiras, R., Wirth, E. K., Kirchner, H., Schweizer, U., Jonas, W., Veyrat-Durebex, C., Rohner-Jeanrenaud, F., Schurmann, A., Joost, H. G., Tschop, M. H., and Perez-Tilve, D. (2012). (In Press). The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. . Physiology & Behavior (105) , 791-799.
  • Stemmer, K., Perez-Tilve, D., Ananthakrishnan, G., Bort, A., Seeley, R. J., Tschop, M. H., Dietrich, D. R., and Pfluger, P. T (2012). (In Press). High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. . Disease Models & Mechanisms (5) , 627-635.
  • Muller, T. D., Sullivan, L. M., Habegger, K., Yi, C. X., Kabra, D., Grant, E., Ottaway, N., Krishna, R., Holland, J., Hembree, J., Perez-Tilve, D., Pfluger, P. T., DeGuzman, M. J., Siladi, M. E., Kraynov, V. S., Axelrod, D. W., DiMarchi, R., Pinkstaff, J. K., and Tschop, M. H. (2012). (In Press). Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21 . Journal of Peptide Science : An Official Publication of the European Peptide Society (18) , 383-393.
  • Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschop, M. H., and Perez-Tilve, D. (2012). (In Press). Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling . Diabetes. (61) , 2753-2762.
  • Kirchner, H., Hofmann, S. M., Fischer-Rosinsky, A., Hembree, J., Abplanalp, W., Ottaway, N., Donelan, E., Krishna, R., Woods, S. C., Muller, T. D., Spranger, J., Perez-Tilve, D., Pfluger, P. T., Tschop, M. H., and Habegger, K. M. (2012). (In Press). Caloric restriction chronically impairs metabolic programming in mice. . Diabetes. (61) , 2734-2742.
  • Heppner, K. M., Chaudhary, N., Muller, T. D., Kirchner, H., Habegger, K. M., Ottaway, N., Smiley, D. L., Dimarchi, R., Hofmann, S. M., Woods, S. C., Sivertsen, B., Holst, B., Pfluger, P. T., Perez-Tilve, D., and Tschop, M. H. (2012). (In Press). Acylation type determines ghrelin&039;s effects on energy homeostasis in rodents. . Endocrinology (153) , 4687-4695.
  • abegger, K. M., Matzke, D., Ottaway, N., Hembree, J., Holland, J., Raver, C., Mansfeld, J., Muller, T. D., Perez-Tilve, D., Pfluger, P. T., Lee, S. J., Diaz-Meco, M., Moscat, J., Leitges, M., Tschop, M. H., and Hofmann, S. M. (2012). (In Press). Role of adipose and hepatic atypical protein kinase C lambda (PKClambda) in the development of obesity and glucose intolerance. . Adipocyte (1) , 203-214.
  • Finan, B., Yang, B., Ottaway, N., Stemmer, K., Muller, T. D., Yi, C. X., Habegger, K., Schriever, S. C., Garcia-Caceres, C., Kabra, D. G., Hembree, J., Holland, J., Raver, C., Seeley, R. J., Hans, W., Irmler, M., Beckers, J., de Angelis, M. H., Tiano, J. P., Mauvais-Jarvis, F., Perez-Tilve, D., Pfluger, P., Zhang, L., Gelfanov, V., DiMarchi, R. D., and Tschop, M. H. (2012). (In Press). Targeted estrogen delivery reverses the metabolic syndrome. . Nature Medicine (18) , 1847-1856.
  • Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschöp, M. H., & Perez-Tilve, D. (2012). Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. . Diabetes , 61 (11) , 2753-62.
  • Kirchner, H., Hofmann, S. M., Fischer-Rosinský, A., Hembree, J., Abplanalp, W., Ottaway, N., Donelan, E., Krishna, R., Woods, S. C., Müller, T. D., Spranger, J., Perez-Tilve, D., Pfluger, P. T., Tschöp, M. H., & Habegger, K. M. (2012). Caloric restriction chronically impairs metabolic programming in mice. . Diabetes , 61 (11) , 2734-42.
  • Habegger, K. M., Matzke, D., Ottaway, N., Hembree, J., Holland, J., Raver, C., Mansfeld, J., Müller, T. D., Perez-Tilve, D., Pfluger, P. T., Lee, S. J., Diaz-Meco, M., Moscat, J., Leitges, M., Tschöp, M. H., & Hofmann, S. M. (2012). Role of adipose and hepatic atypical protein kinase C lambda (PKC?) in the development of obesity and glucose intolerance. . Adipocyte , 1 (4) , 203-214.
  • Heppner, K. M., Chaudhary, N., Müller, T. D., Kirchner, H., Habegger, K. M., Ottaway, N., Smiley, D. L., Dimarchi, R., Hofmann, S. M., Woods, S. C., Sivertsen, B., Holst, B., Pfluger, P. T., Perez-Tilve, D., & Tschöp, M. H. (2012). Acylation type determines ghrelin's effects on energy homeostasis in rodents. . Endocrinology , 153 (10) , 4687-95.
  • Stemmer, K., Perez-Tilve, D., Ananthakrishnan, G., Bort, A., Seeley, R. J., Tschöp, M. H., Dietrich, D. R., & Pfluger, P. T. (2012). High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. . Disease Models & Mechanisms , 5 (5) , 627-35.
  • Müller, T. D., Sullivan, L. M., Habegger, K., Yi, C., Kabra, D., Grant, E., Ottaway, N., Krishna, R., Holland, J., Hembree, J., Perez-Tilve, D., Pfluger, P. T., DeGuzman, M. J., Siladi, M. E., Kraynov, V. S., Axelrod, D. W., DiMarchi, R., Pinkstaff, J. K., & Tschöp, M. H. (2012). Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. . Journal of Peptide Science : An Official Publication of the European Peptide Society , 18 (6) , 383-93.
  • Perez-Tilve, D., Davidson, W. S., Tschöp, M., & Hofmann, S. M. (2011). (In Press). CNS regulation of plasma cholesterol. . Annals of Medicine.
  • Perez-Tilve, D., Heppner, K., Kirchner, H., Lockie, S. H., Woods, S. C., Smiley, D. L., Tschöp, M., & Pfluger, P. (2011). (In Press). Ghrelin-induced adiposity is independent of orexigenic effects. . The FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology.
  • Pfluger, P. T., Castañeda, T. R., Heppner, K. M., Strassburg, S., Kruthaupt, T., Chaudhary, N., Halem, H., Culler, M. D., Datta, R., Burget, L., Tschöp, M. H., Nogueiras, R., & Perez-Tilve, D. (2011). (In Press). Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. . Physiology & Behavior.
  • Patterson, J. T., Ottaway, N., Gelfanov, V. M., Smiley, D. L., Perez-Tilve, D., Pfluger, P. T., Tschöp, M. H., & Dimarchi, R. D. (2011). (In Press). A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1. . ACS Chemical Biology , 6 (2) , 135-45.
  • Lockie, S. H., Czyzyk, T. A., Chaudhary, N., Perez-Tilve, D., Woods, S. C., Oldfield, B. J., Statnick, M. A., & Tschöp, M. H. (2011). CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice. . Endocrinology , 152 (10) , 3661-7.
  • Perez-Tilve, D., Habbeger, K. M., Tschöp, M. H., & Hofmann, S. M. (2011). Neural regulation of cholesterol metabolism. . Current Opinion in Lipidology , 22 (4) , 283-7.
  • Habegger, K. M., Grant, E., Pfluger, P. T., Perez-Tilve, D., Daugherty, A., Bruemmer, D., Tschöp, M. H., & Hofmann, S. M. (2011). Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice. . Frontiers in Endocrinology , 2 , 67.
  • Müller, T. D., Perez-Tilve, D., Tong, J., Pfluger, P. T., & Tschöp, M. H. (2010). (In Press). Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia. . Journal of Cachexia, Sarcopenia and Muscle , 1 (2) , 159-167.
  • Strassburg, S., Pfluger, P. T., Chaudhary, N., Tso, P., Tschöp, M. H., Anker, S. D., Nogueiras, R., & Perez-Tilve, D. (2010). (In Press). Action profile of the antiobesity drug candidate oleoyl-estrone in rats. . Obesity (Silver Spring, Md.) , 18 (12) , 2260-7.
  • Horvath, T. L., Sarman, B., García-Cáceres, C., Enriori, P. J., Sotonyi, P., Shanabrough, M., Borok, E., Argente, J., Chowen, J. A., Perez-Tilve, D., Pfluger, P. T., Brönneke, H. S., Levin, B. E., Diano, S., Cowley, M. A., & Tschöp, M. H. (2010). (In Press). Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. . Proceedings of the National Academy of Sciences of the United States of America , 107 (33) , 14875-80.
  • Heppner, K. M., Habegger, K. M., Day, J., Pfluger, P. T., Perez-Tilve, D., Ward, B., Gelfanov, V., Woods, S. C., DiMarchi, R., & Tschöp, M. (2010). (In Press). Glucagon regulation of energy metabolism. . Physiology & Behavior , 100 (5) , 545-8.
  • Lee, S. J., Kim, J. Y., Nogueiras, R., Linares, J. F., Perez-Tilve, D., Jung, D. Y., Ko, H. J., Hofmann, S. M., Drew, A., Leitges, M., Kim, J. K., Tschöp, M. H., Diaz-Meco, M. T., & Moscat, J. (2010). (In Press). PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. . Cell Metabolism , 12 (1) , 65-77.
  • Perez-Tilve, D., Hofmann, S. M., Basford, J., Nogueiras, R., Pfluger, P. T., Patterson, J. T., Grant, E., Wilson-Perez, H. E., Granholm, N. A., Arnold, M., Trevaskis, J. L., Butler, A. A., Davidson, W. S., Woods, S. C., Benoit, S. C., Sleeman, M. W., DiMarchi, R. D., Hui, D. Y., & Tschöp, M. H. (2010). (In Press). Melanocortin signaling in the CNS directly regulates circulating cholesterol. . Nature Neuroscience , 13 (7) , 877-82.
  • Gil-Lozano, M., Pérez-Tilve, D., Alvarez-Crespo, M., Martís, A., Fernandez, A. M., Catalina, P. A. F., Gonzalez-Matias, L. C., & Mallo, F. (2010). (In Press). GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans. . Endocrinology , 151 (6) , 2629-40.
  • Stefater, M. A., Pérez-Tilve, D., Chambers, A. P., Wilson-Pérez, H. E., Sandoval, D. A., Berger, J., Toure, M., Tschöp, M., Woods, S. C., & Seeley, R. J. (2010). (In Press). Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. . Gastroenterology , 138 (7) , 2426-36, 2436.e1-3.
  • Pérez-Tilve, D., González-Matías, L., Aulinger, B. A., Alvarez-Crespo, M., Gil-Lozano, M., Alvarez, E., Andrade-Olivie, A. M., Tschöp, M. H., D'Alessio, D. A., & Mallo, F. (2010). (In Press). Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system. . American Journal of Physiology. Endocrinology and Metabolism , 298 (5) , E1088-96.
  • Tschöp, J., Nogueiras, R., Haas-Lockie, S., Kasten, K. R., Castañeda, T. R., Huber, N., Guanciale, K., Perez-Tilve, D., Habegger, K., Ottaway, N., Woods, S. C., Oldfield, B., Clarke, I., Chua, S., Farooqi, I. S., O'Rahilly, S., Caldwell, C. C., & Tschöp, M. H. (2010). (In Press). CNS leptin action modulates immune response and survival in sepsis. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 30 (17) , 6036-47.
  • Sutton, G. M., Begriche, K., Kumar, K. G., Gimble, J. M., Perez-Tilve, D., Nogueiras, R., McMillan, R. P., Hulver, M. W., Tschöp, M. H., & Butler, A. A. (2010). (In Press). Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. . The FASEB Journal : Official Publication of the Federation of American Societies For Experimental Biology , 24 (3) , 862-72.
  • Day, J. W., Ottaway, N., Patterson, J. T., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., Holland, J., Hembree, J., Abplanalp, W., Grant, E., Ruehl, J., Wilson, H., Kirchner, H., Lockie, S. H., Hofmann, S., Woods, S. C., Nogueiras, R., Pfluger, P. T., Perez-Tilve, D., DiMarchi, R., & Tschöp, M. H. (2009). (In Press). A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. . Nature Chemical Biology , 5 (10) , 749-57.
  • Nogueiras, R., Pérez-Tilve, D., Veyrat-Durebex, C., Morgan, D. A., Varela, L., Haynes, W. G., Patterson, J. T., Disse, E., Pfluger, P. T., López, M., Woods, S. C., DiMarchi, R., Diéguez, C., Rahmouni, K., Rohner-Jeanrenaud, F., & Tschöp, M. H. (2009). (In Press). Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 29 (18) , 5916-25.
  • Sutton, G. M., Perez-Tilve, D., Nogueiras, R., Fang, J., Kim, J. K., Cone, R. D., Gimble, J. M., Tschöp, M. H., & Butler, A. A. (2008). (In Press). The melanocortin-3 receptor is required for entrainment to meal intake. . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience , 28 (48) , 12946-55.
  • Perez-Tilve, D., D'Alessio, D. A., & Tschöp, M. H. (2008). (In Press). A sweet spot for the bariatric surgeon. . Cell Metabolism , 8 (3) , 177-9.
  • Strassburg, S., Anker, S. D., Castaneda, T. R., Burget, L., Perez-Tilve, D., Pfluger, P. T., Nogueiras, R., Halem, H., Dong, J. Z., Culler, M. D., Datta, R., & Tschöp, M. H. (2008). (In Press). Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. . American Journal of Physiology. Endocrinology and Metabolism , 295 (1) , E78-84.
  • Nogueiras, R., López, M., Lage, R., Perez-Tilve, D., Pfluger, P., Mendieta-Zerón, H., Sakkou, M., Wiedmer, P., Benoit, S. C., Datta, R., Dong, J. Z., Culler, M., Sleeman, M., Vidal-Puig, A., Horvath, T., Treier, M., Diéguez, C., & Tschöp, M. H. (2008). (In Press). Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. . Endocrinology , 149 (6) , 3009-15.
  • López, M., Lage, R., Saha, A. K., Pérez-Tilve, D., Vázquez, M. J., Varela, L., Sangiao-Alvarellos, S., Tovar, S., Raghay, K., Rodríguez-Cuenca, S., Deoliveira, R. M., Castañeda, T., Datta, R., Dong, J. Z., Culler, M., Sleeman, M. W., Alvarez, C. V., Gallego, R., Lelliott, C. J., Carling, D., Tschöp, M. H., Diéguez, C., & Vidal-Puig, A. (2008). (In Press). Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. . Cell Metabolism , 7 (5) , 389-99.
  • Pfluger, P. T., Kirchner, H., Günnel, S., Schrott, B., Perez-Tilve, D., Fu, S., Benoit, S. C., Horvath, T., Joost, H., Wortley, K. E., Sleeman, M. W., & Tschöp, M. H. (2008). (In Press). Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 294 (3) , G610-8.
  • Tizzano, J. P., Stribling, D. S., Perez-Tilve, D., Strack, A., Frassetto, A., Chen, R. Z., Fong, T. M., Shearman, L., Krieter, P. A., Tschöp, M. H., Skolnick, P., & Basile, A. S. (2008). (In Press). The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. . The Journal of Pharmacology and Experimental Therapeutics , 324 (3) , 1111-26.
  • Hofmann, S. M., Perez-Tilve, D., Greer, T. M., Coburn, B. A., Grant, E., Basford, J. E., Tschöp, M. H., & Hui, D. Y. (2008). (In Press). Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. . Diabetes , 57 (1) , 5-12.
  • Hofmann, S. M., Zhou, L., Perez-Tilve, D., Greer, T., Grant, E., Wancata, L., Thomas, A., Pfluger, P. T., Basford, J. E., Gilham, D., Herz, J., Tschöp, M. H., & Hui, D. Y. (2007). (In Press). Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. . The Journal of Clinical Investigation , 117 (11) , 3271-82.
  • Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., Howles, P. N., Morgan, D. A., Benoit, S. C., Szanto, I., Schrott, B., Schürmann, A., Joost, H., Hammond, C., Hui, D. Y., Woods, S. C., Rahmouni, K., Butler, A. A., Farooqi, I. S., O'Rahilly, S., Rohner-Jeanrenaud, F., & Tschöp, M. H. (2007). (In Press). The central melanocortin system directly controls peripheral lipid metabolism. . The Journal of Clinical Investigation , 117 (11) , 3475-88.
  • Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E. B., Jones, K. L., Kawamori, R., Cassis, L. A., Tschöp, M. H., & Bruemmer, D. (2007). (In Press). Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. . The Journal of Clinical Investigation , 117 (10) , 2877-88.
  • Spuch, C., Diz-Chaves, Y., Pérez-Tilve, D., Alvarez-Crespo, M., & Mallo, F. (2007). (In Press). Prolactin-releasing Peptide (PrRP) increases prolactin responses to TRH in vitro and in vivo. . Endocrine , 31 (2) , 119-24.
  • Pérez-Tilve, D., González-Matías, L., Alvarez-Crespo, M., Leiras, R., Tovar, S., Diéguez, C., & Mallo, F. (2007). (In Press). Exendin-4 potently decreases ghrelin levels in fasting rats. . Diabetes , 56 (1) , 143-51.
  • Nogueiras, R., Pfluger, P., Tovar, S., Arnold, M., Mitchell, S., Morris, A., Perez-Tilve, D., Vázquez, M. J., Wiedmer, P., Castañeda, T. R., DiMarchi, R., Tschöp, M., Schurmann, A., Joost, H., Williams, L. M., Langhans, W., & Diéguez, C. (2007). (In Press). Effects of obestatin on energy balance and growth hormone secretion in rodents. . Endocrinology , 148 (1) , 21-6.
  • Theander-Carrillo, C., Wiedmer, P., Cettour-Rose, P., Nogueiras, R., Perez-Tilve, D., Pfluger, P., Castaneda, T. R., Muzzin, P., Schürmann, A., Szanto, I., Tschöp, M. H., & Rohner-Jeanrenaud, F. (2006). (In Press). Ghrelin action in the brain controls adipocyte metabolism. . The Journal of Clinical Investigation , 116 (7) , 1983-93.
  • Spuch, C., Diz-Chaves, Y., Pérez-Tilve, D., & Mallo, F. (2006). (In Press). Fibroblast growth factor-2 and epidermal growth factor modulate prolactin responses to TRH and dopamine in primary cultures. . Endocrine , 29 (2) , 317-24.
  • Perez-Tilve, D., Stern, J. E., & Tschöp, M. (2006). (In Press). The brain and the metabolic syndrome: not a wireless connection. . Endocrinology , 147 (3) , 1136-9.
  • Perez-Tilve, D., Nogueiras, R., Mallo, F., Benoit, S. C., & Tschoep, M. (2006). (In Press). Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism. . Endocrine , 29 (1) , 61-71.
  • Spuch, C., Diz-Chaves, Y., Pérez-Tilve, D., & Mallo, F. (2004). (In Press). Heparin increases prolactin and modifies the effects of fgf-2 upon prolactin accumulation in pituitary primary cultures. . Endocrine , 24 (2) , 131-6.
  • Diz Chaves, Y., Spuch Calvar, C., Pérez Tilve, D., & Mallo Ferrer, F. (2003). (In Press). GH responses to GHRH and GHRP-6 in Streptozotocin (STZ)-diabetic rats. . Life Sciences , 73 (26) , 3375-85.

    Research Grants:

  • R01 DK077975 National Inst of Diabetes and Digestive and Kidney Disease. Neuroendocrine Regulation of Adipocyte Metabolism, PI, Active.
  • Insulin Tests in Rodents Calibrium. Novel peptide-based therapies for the treatment of diabetes, PI, Active.

Recent Awards/Honors:

  • Predoctoral Fellowship. University of Vigo, Spain, 1999,2001
  • Predoctoral Fellowship. Autonomic Government of Galicia, Spain, 2001,2004
  • Postdoctoral Fellowship. Autonomic Government of Galicia and Spanish Ministry of Education and Science, Spain, 2004,2006
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