Department Directory

  • Karen Ryan, PhD
  • Assistant Professor of Endocrinology
  • Phone: 513-558-4065
  • Email:

    Research/Clinical Interests:

  • Neuroendocrine Regulation of Metabolism, Nuclear Receptors.


  • Doctoral Degree: University of Chicago
  • Bachelor's Degree: Washington University
  • Postdoctoral Fellowship : University of Cincinnati , 2011

Peer Reviewed Publications (in chronological order):

  • Ryan, K. K., Mul, J. D., Clemmensen, C., Egan, A. E., Begg, D. P., Halcomb, K., Seeley, R. J., Herman, J. P., & Ulrich-Lai, Y. M. (2014). Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress. . Psychoneuroendocrinology , 42 , 98-105.
  • Ryan, K. K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F., & Seeley, R. J. (2014). FXR is a molecular target for the effects of vertical sleeve gastrectomy. . Nature.
  • Ulrich-Lai, Y. M., & Ryan, K. K. (2014). Neuroendocrine Circuits Governing Energy Balance and Stress Regulation: Functional Overlap and Therapeutic Implications. . Cell Metabolism.
  • Wilson-Pérez, H. E., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D., Drucker, D. J., Pérez-Tilve, D., & Seeley, R. J. (2013). Vertical Sleeve Gastrectomy is Effective in Two Genetic Mouse Models of Glucagon-like Peptide-1 Receptor Deficiency. . Diabetes.
  • Ryan, K. K., & Seeley, R. J. (2013). Physiology. Food as a hormone. . Science (New York, N.Y.) , 339 (6122) , 918-9.
  • Clemmensen, C., Smajilovic, S., Smith, E. P., Woods, S. C., Bräuner-Osborne, H., Seeley, R. J., D'Alessio, D. A., & Ryan, K. K. (2013). Oral L-arginine Stimulates GLP-1 Secretion to Improve Glucose Tolerance in Male Mice. . Endocrinology.
  • Kohli, R., Setchell, K. D., Kirby, M., Myronovych, A., Ryan, K. K., Ibrahim, S. H., Berger, J., Smith, K., Toure, M., Woods, S. C., & Seeley, R. J. (2013). A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery. . Endocrinology , 154 (7) , 2341-51.
  • Myronovych, A., Kirby, M., Ryan, K. K., Zhang, W., Jha, P., Setchell, K. D., Dexheimer, P. J., Aronow, B., Seeley, R. J., & Kohli, R. (2013). Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. . Obesity (Silver Spring, Md.).
  • Ryan, K. K., Grayson, B. E., Jones, K. R., Schneider, A. L., Woods, S. C., Seeley, R. J., Herman, J. P., & Ulrich-Lai, Y. M. (2012). Physiological responses to acute psychological stress are reduced by the PPAR? agonist rosiglitazone. . Endocrinology , 153 (3) , 1279-87.
  • Ryan, K. K., Woods, S. C., & Seeley, R. J. (2012). Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. . Cell Metabolism , 15 (2) , 137-49.
  • Ryan, K. K., Kohli, R., Gutierrez-Aguilar, R., Gaitonde, S. G., Woods, S. C., & Seeley, R. J. (2012). Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats. . Endocrinology.
  • Chambers, A. P., Wilson-Perez, H. E., McGrath, S., Grayson, B. E., Ryan, K. K., D'Alessio, D. A., Woods, S. C., Sandoval, D. A., & Seeley, R. J. (2012). Effect of vertical sleeve gastrectomy on food selection and satiation in rats. . American Journal of Physiology. Endocrinology and Metabolism , 303 (8) , E1076-84.
  • Ulrich-Lai, Y. M., & Ryan, K. K. (2012). PPAR? and stress: Implications for aging. . Experimental Gerontology.
  • Sandoval, D. A., Ryan, K. K., de Kloet, A. D., Woods, S. C., & Seeley, R. J. (2012). Female rats are relatively more sensitive to reduced lipid versus reduced carbohydrate availability. . Nutrition & Diabetes , 2 , e27.
  • Chambers, A. P., Stefater, M. A., Wilson-Perez, H. E., Jessen, L., Sisley, S., Ryan, K. K., Gaitonde, S., Sorrell, J. E., Toure, M., Berger, J., D'Alessio, D. A., Sandoval, D. A., Seeley, R. J., & Woods, S. C. (2011). Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. . Physiology & Behavior , 105 (1) , 120-3.
  • Chambers, A. P., Jessen, L., Ryan, K. K., Sisley, S., Wilson-Pérez, H. E., Stefater, M. A., Gaitonde, S. G., Sorrell, J. E., Toure, M., Berger, J., D'Alessio, D. A., Woods, S. C., Seeley, R. J., & Sandoval, D. A. (2011). Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. . Gastroenterology , 141 (3) , 950-8.
  • Ryan, K. K., Li, B., Grayson, B. E., Matter, E. K., Woods, S. C., & Seeley, R. J. (2011). A role for central nervous system PPAR-? in the regulation of energy balance. . Nature Medicine , 17 (5) , 623-6.
  • Ryan, K. K., Haller, A. M., Sorrell, J. E., Woods, S. C., Jandacek, R. J., & Seeley, R. J. (2010). Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice. . Endocrinology , 151 (6) , 2603-12.

    Research Grants:

  • R01 DK078201 National Inst of Diabetes and Digestive and Kidney Disease. The Role of TNF Alpha in Obesity, Collaborator, Active.
  • F32 DK082173 National Inst of Diabetes and Digestive and Kidney Disease. The Role of Hypothalamic PPARg in Diet-Induced Obesity, PI, Closed.
  • K99HL111319 National Heart, Lung and Blood Institute. CNS PPARg, Stress, and Cardiovascular Disease, PI, Active.
CARE/Crawley Building

More Information

For more information on the UC Department of Internal Medicine, please contact us at:

UC Department of Internal Medicine
231 Albert Sabin Way
Medical Sciences Building Room 6065
PO Box 670557
Cincinnati, OH 45267-0557

Phone: 513-558-4231
Fax: 513-558-0852