Department Directory

  • Jason C. Steel, PhD
  • Research Assistant Professor, Department of Internal Medicine, UC College of Medicine
  • Academic Office:
    Vontz Center for Molecular Studies
    3125 Eden Ave, Room 1302
    Cincinnati, OH 45267
  • Phone: (513) 558-2228
  • Email: Jason.Steel@uc.edu

    Research/Clinical Interests:

  • §   Immunotherapy for cancer;
    §   Cancer Stem Cells and their role in immune escape;
    §   Viral vaccine development for cancer and infectious disease;
    §   Development of gene delivery systems;
    §   Development of gene therapy strategies for cancer;
    §   The development and evaluation of cellular vaccines for cancer;
    §   The use of interleukin-15 (IL-15) and its receptor (IL-15Ra) for immunotherapy;
    §   The evaluation of IL-15 and IL-15Ra in cancerous and non-cancerous lung tissue

    Education/Credentials:

  • Bacherlor's Degree: Charles Sturt University Wagga Wagga, 1997
  • Bacherlor's Degree: Charles Sturt University Wagga Wagga, 1998
  • Ph.D.: Charles Sturt University Wagga Wagga, 2004
  • Post-Doctoral Fellowship: Cancer Gene Therapy Laboratory,National Cancer Institute, National Institutes of Health, 2007
  • Post-Doctoral Fellowship: Cytokine Immunology and Immunotherapy Laboratory,National Cancer Institute, National Institutes of Health, 2009

Peer Reviewed Publications (in chronological order):

  • Yu, P., Steel, J. C., Zhang, M., Morris, J. C., Waitz, R., Fasso, M., Allison, J. P., & Waldmann, T. A. (2012). Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model. . Proceedings of the National Academy of Sciences of the United States of America , 109 (16) , 6187-92.
  • Steel, J. C., Waldmann, T. A., & Morris, J. C. (2012). Interleukin-15 biology and its therapeutic implications in cancer. . Trends in Pharmacological Sciences , 33 (1) , 35-41.
  • Yu, P., Steel, J. C., Zhang, M., Morris, J. C., & Waldmann, T. A. (2010). Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model. . Clinical Cancer Research : An Official Journal of the American Association For Cancer Research , 16 (24) , 6019-28.
  • Steel, J. C., Ramlogan, C. A., Yu, P., Sakai, Y., Forni, G., Waldmann, T. A., & Morris, J. C. (2010). Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help. . Cancer Research , 70 (3) , 1072-81.
  • Yu, P., Xiong, S., He, Q., Chu, Y., Lu, C., Ramlogan, C. A., & Steel, J. C. (2009). Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts. . Immunology , 127 (4) , 500-11.
  • Park, J. M., Terabe, M., Steel, J. C., Forni, G., Sakai, Y., Morris, J. C., & Berzofsky, J. A. (2008). Therapy of advanced established murine breast cancer with a recombinant adenoviral ErbB-2/neu vaccine. . Cancer Research , 68 (6) , 1979-87.
  • Steel, J. C., Morrison, B. J., Mannan, P., Abu-Asab, M. S., Wildner, O., Miles, B. K., Yim, K. C., Ramanan, V., Prince, G. A., & Morris, J. C. (2007). Immunocompetent syngeneic cotton rat tumor models for the assessment of replication-competent oncolytic adenovirus. . Virology , 369 (1) , 131-42.
  • Steel, J. C., Cavanagh, H. M. A., Burton, M. A., Abu-Asab, M. S., Tsokos, M., Morris, J. C., & Kalle, W. H. J. (2007). Increased tumor localization and reduced immune response to adenoviral vector formulated with the liposome DDAB/DOPE. . European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences , 30 (5) , 398-405.
  • Steel, J. C., Cavanagh, H. M. A., Burton, M. A., Dingwall, D. J., & Kalle, W. H. J. (2005). Modification of liposomal concentration in liposome/adenoviral complexes allows significant protection of adenoviral vectors from neutralising antibody, in vitro. . Journal of Virological Methods , 126 (1-2) , 31-6.
  • Steel, J. C., Cavanagh, H. M. A., Burton, M. A., & Kalle, W. H. J. (2004). Microsphere-liposome complexes protect adenoviral vectors from neutralising antibody without losses in transfection efficiency, in-vitro. . The Journal of Pharmacy and Pharmacology , 56 (11) , 1371-8.
  • Steel, J. C., Cavanagh, H. M. A., Burton, M. A., Dingwall, D., & Kalle, W. H. J. (2004). In-vitro evaluation of ion-exchange microspheres for the sustained release of liposomal-adenoviral conjugates. . Journal of Controlled Release : Official Journal of the Controlled Release Society , 95 (3) , 601-11.
  • Steel, J. C., Kalle, W. H. J., Dingwall, D. J., Cavanagh, H. M. A., & Burton, M. A. (2004). Pre-treatment with a non-therapeutic dose of cisplatin increases solid tumour response to liposomal-p53 gene therapy- An in vivo study. . Cancer Therapy , 2 , 239-244.
  • Cavanagh, H. M., Dingwall, D., Steel, J., Benson, J., & Burton, M. (2001). Cell contact dependent extended release of adenovirus by microparticles in vitro. . Journal of Virological Methods , 95 (1-2) , 57-64.

Book Chapter:

  • Morrison BJ., Steel JC., Gregory M., Morris JC., Malyguine AM. (2009). Genetically Modified Dendritic Cells in Cancer Immunotherapy In Shrin MR., Salter RD (Eds.) , Dendritic Cells in Cancer (pp. 347 , 364). New York, NY : Springer . Co-Author.
  • Morrison BJ., Steel JC. (2012). (In Press). Lung cancer Stem Cells In Guitron J, Redmond K, Morris JC (Eds.) , Thoracic Oncology: A multidisciplinary approach : Wiley . Co-Author.
  • Ramlogan CA., Steel JC., Morris JC (2012). (In Press). Immunotherapy of Lung Cancer In Guitron J, Redmond K, Morris JC (Eds.) , Thoracic Oncology: A multidisciplinary approach . Co-Author.
  • Steel JC., Morrison BJ., Morris JC. (2012). (In Press). Monoclonal Antibody Therapy of Cancer In Tan D, Lynch H. (Eds.) , Priniciples of Molecular Diagnostics and Personal Cancer Medicine : Lippincott, Williams & Wilkins . Co-Author.

Recent Awards/Honors:

  • International Society of Biological Therapy of Cancer Presidential Travel Award, 2008
  • NIH Fellows Award for Research Excellence (FARE), 2008
  • NIH Fellows Award for Research Excellence (FARE), 2007
  • NIH Fellows Award for Research Excellence (FARE), 2006
  • National Institutes of Health, Fogerty International Research Fellowship, 2005,2010
  • Awarded International Society of Cancer Gene Therapy Travel Bursary, 2003,2004
  • Awarded CSU Postgraduate Research Scholarship, 2001,2004
CARE/Crawley Building

More Information


For more information on the UC Department of Internal Medicine, please contact us at:

UC Department of Internal Medicine
231 Albert Sabin Way
Medical Sciences Building Room 6065
PO Box 670557
Cincinnati, OH 45267-0557

Phone: 513-558-4231
Fax: 513-558-0852
Email: ucintmed@uc.edu