Department Directory

  • Stephen Zucker, MD
  • Associate Professor of Medicine
    Director, Gastroenterology and Transplant Hepatology Training Programs
  • Academic Office:
    Medical Sciences Building, 6th Floor
    231 Albert Sabin Way
    Cincinnati, OH 45267
  • Clinical Office:
    UC Health Physicians Office - Clifton
    222 Piedmont Ave., 4th Floor
    Cincinnati, OH 45219
  • Phone: 513-558-7200
  • Email: zuckersd@email.uc.edu

    Research/Clinical Interests:

  • Physiological Functions of Bilirubin, Mechanisms of Delivery and Transport of Small Hydrophobic Compounds by the Liver, Pathophysiology of Kernicteru.

    Education/Credentials:

  • Bachelor's Degree: Swarthmore College, 1981
  • Medical Degree: Harvard Medical School, 1985
  • Internship: Bringham and Women's Hospital, 1986
  • Residency: Brigham and Women's Hospital , 1988
  • Fellowship: Brigham and Women's Hospital, 1991

Board Certifications & Licenses:

  • State of Massachusetts License Registration, 1986
  • American Board of Internal Medicine Certificate, 1988
  • American Board of Internal Medicine, 1992, Gastroenterology Subspecialty Certificate
  • State of Ohio License Registration, 1998
  • American Board of Internal Medicine, 2003, Gastroenterology Subspecialty re-Certification

Peer Reviewed Publications (in chronological order):

  • Smith, D. L. H., Keshavan, P., Avissar, U., Ahmed, K., & Zucker, S. D. (2010). Sodium Taurocholate Inhibits Intestinal Adenoma Formation in APCMin/+ Mice, Potentially through Activation of the Farnesoid X Receptor (FXR). . Carcinogenesis.
  • Barry CT, Avissar U, Asebrook M, Sostok MA, Sherman KE, Zucker SD (2010). (In Press). Use of a standardized patient exercise to assess core competencies during fellowship training . J. Grad. Med. Educ..
  • Smith DLH, Keshavan P, Avissar U, Ahmed K, Zucker SD (2010). (In Press). Sodium taurocholate suppresses intestinal adenoma formation in APCMin/+ mice, potentially through activation of the farnesoid X receptor . Carcinogenesis.
  • Ahmed, K., & Zucker, S. (2008). Giant cell hepatitis in a teenage woman . Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association , 6 (1) , A26 , 26.e1.
  • Limketkai, B., & Zucker, S. (2008). Hyperammonemic encephalopathy caused by carnitine deficiency . Journal of General Internal Medicine : Official Journal of the Society For Research and Education in Primary Care Internal Medicine , 23 (2) , 210 , 213.
  • Limketkai, B. N., & Zucker, S. D. (2008). Hyperammonemic encephalopathy caused by carnitine deficiency. . Journal of General Internal Medicine , 23 (2) , 210-3.
  • Ahmed, K., & Zucker, S. D. (2008). Giant cell hepatitis in a teenage woman. . Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association , 6 (1) , A26-26.e1.
  • Zucker,S.D. (2006). Cirrhosis-associated mortality: frankly, scarlet, do we really make a damn? . Gastroenterology , 131 (1) , 320 , 322.
  • Chun, S., & Zucker, S. (2006). Combination therapy for chronic hepatitis b: a one-two knockout punch, or a swing and a miss? . Gastroenterology , 130 (2) , 613 , 4; discussion 514-5.
  • Smith, D., Shire, N., Watts, N., Schmitter, T., Szabo, G., & Zucker, S. (2006). Hyperbilirubinemia is not a major contributing factor to altered bone mineral density in patients with chronic liver disease . Journal of Clinical Densitometry : the Official Journal of the International Society For Clinical Densitometry , 9 (1) , 105 , 113.
  • Zucker, S., Benedict, M., & Sherman, K. (2006). Serum bilirubin and risk of colorectal cancer . Alimentary Pharmacology & Therapeutics , 24 (8) , 1257 , 9; author reply 1259-61.
  • Zucker, S. D., Benedict, M., & Sherman, K. E. (2006). Serum bilirubin and risk of colorectal cancer. . Alimentary Pharmacology & Therapeutics , 24 (8) , 1257-9; author reply.
  • Zucker, Stephen D (2006). Cirrhosis-associated mortality: frankly, scarlet, do we really make a damn? . Gastroenterology , 131 (1) , 320-2.
  • Chun, S., & Zucker, S. D. (2006). Combination therapy for chronic hepatitis B: a one-two knockout punch, or a swing and a miss? . Gastroenterology , 130 (2) , 613-4; discussion 51.
  • Zucker,S.D. (2005). Ironing out the cryptic intestinal defect in hereditary hemochromatosis . Gastroenterology , 128 (3) , 794 , 6; discussion 796-7.
  • Zucker,S.D. (2005). Response to rigato et al.: bilirubin and non-hepatic disease--a jaundiced view . Trends in Molecular Medicine , 11 (7) , 313 , 4; author reply 314-5.
  • Keshavan, P., Deem, T., Schwemberger, S., Babcock, G., Cook-Mills, J., & Zucker, S. (2005). Unconjugated bilirubin inhibits vcam-1-mediated transendothelial leukocyte migration . Journal of Immunology (Baltimore, Md.: 1950) , 174 (6) , 3709 , 3718.
  • Zucker, Stephen D (2005). Response to Rigato et al.: bilirubin and non-hepatic disease--a jaundiced view. . Trends in Molecular Medicine , 11 (7) , 313-4; author reply .
  • Keshavan, P., Deem, T. L., Schwemberger, S. J., Babcock, G. F., Cook-Mills, J. M., & Zucker, S. D. (2005). Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration. . Journal of Immunology (Baltimore, Md. : 1950) , 174 (6) , 3709-18.
  • Zucker, Stephen D (2005). Ironing out the cryptic intestinal defect in hereditary hemochromatosis. . Gastroenterology , 128 (3) , 794-6; discussion 79.
  • Zucker, S., & Sherman, K. (2004). Beyond interferon for hepatitis c: living in the present while hoping for the future . Gastroenterology , 126 (5) , 1487 , 1488.
  • Wang, W., Smith, D., & Zucker, S. (2004). Bilirubin inhibits inos expression and no production in response to endotoxin in rats . Hepatology (Baltimore, Md.) , 40 (2) , 424 , 433.
  • Zucker,S.D. (2004). Can de-bugging the system prevent complications of cirrhosis? the answer may be no . Gastroenterology , 126 (3) , 926 , 8; discussion 928.
  • Holt, A., & Zucker, S. (2004). Hepatitis c infection with normal transaminases: is the treatment worse than the disease? . Gastroenterology , 127 (2) , 677 , 679.
  • Zucker, S., Horn, P., & Sherman, K. (2004). Serum bilirubin levels in the u.s. population: gender effect and inverse correlation with colorectal cancer . Hepatology (Baltimore, Md.) , 40 (4) , 827 , 835.
  • Keshavan, P., Schwemberger, S., Smith, D., Babcock, G., & Zucker, S. (2004). Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization . International Journal of Cancer.Journal International Du Cancer , 112 (3) , 433 , 445.
  • Keshavan, P., Schwemberger, S. J., Smith, D. L. H., Babcock, G. F., & Zucker, S. D. (2004). Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. . International Journal of Cancer. Journal International Du Cancer , 112 (3) , 433-45.
  • Zucker, S. D., Horn, P. S., & Sherman, K. E. (2004). Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer. . Hepatology (Baltimore, Md.) , 40 (4) , 827-35.
  • Holt, A. F., & Zucker, S. D. (2004). Hepatitis C infection with normal transaminases: is the treatment worse than the disease? . Gastroenterology , 127 (2) , 677-9.
  • Wang, W. W., Smith, D. L. H., & Zucker, S. D. (2004). Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. . Hepatology (Baltimore, Md.) , 40 (2) , 424-33.
  • Zucker, S. D., & Sherman, K. E. (2004). Beyond interferon for hepatitis C: living in the present while hoping for the future. . Gastroenterology , 126 (5) , 1487-8.
  • Zucker, Stephen D (2004). Can de-bugging the system prevent complications of cirrhosis? The answer may be no. . Gastroenterology , 126 (3) , 926-8; discussion 92.
  • Morelli, M., & Zucker, S. (2003). A role for the appendix in inflammatory bowel disease? cut it out . Gastroenterology , 125 (4) , 1270 , 2; discussion 1272.
  • Chauhan, S., & Zucker, S. (2003). Hypercholesterolemia in primary biliary cirrhosis: getting to the heart of the matter? . Gastroenterology , 124 (3) , 854 , 856.
  • Zucker,S.D. (2003). Is it hellpful to consider the hanging lchad in pregnancy-associated liver disease? . Gastroenterology , 124 (5) , 1548 , 50; discussion 1550.
  • Doshi, S., & Zucker, S. (2003). Liver emergencies during pregnancy . Gastroenterology Clinics of North America , 32 (4) , 1213 , 27, ix.
  • Doshi, S., & Zucker, S. D. (2003). Liver emergencies during pregnancy. . Gastroenterology Clinics of North America , 32 (4) , 1213-27, ix.
  • Morelli, M. S., & Zucker, S. D. (2003). A role for the appendix in inflammatory bowel disease? Cut it out. . Gastroenterology , 125 (4) , 1270-2; discussion 1.
  • Zucker, Stephen D (2003). Is it HELLPful to consider the hanging LCHAD in pregnancy-associated liver disease? . Gastroenterology , 124 (5) , 1548-50; discussion .
  • Chauhan, S. S., & Zucker, S. D. (2003). Hypercholesterolemia in primary biliary cirrhosis: getting to the heart of the matter? . Gastroenterology , 124 (3) , 854-6.
  • Zucker,S.D. (2002). All kidding aside with the use of lamivudine in children with chronic hepatitis b . Gastroenterology , 123 (5) , 1741 , 3; discussion 1743.
  • Zucker,S.D. (2002). Some tips for the prevention of recurrent variceal hemorrhage? . Gastroenterology , 123 (1) , 384 , 6; discussion 386-7.
  • Weisiger, R., & Zucker, S. (2002). Transfer of fatty acids between intracellular membranes: roles of soluble binding proteins, distance, and time . American Journal of Physiology.Gastrointestinal and Liver Physiology , 282 (1) , G105 , 15.
  • Zucker,S.D. (2002). Whomsoever ignores the natural history of the hepatitis c virus is doomed to treat it . Gastroenterology , 122 (2) , 578 , 579.
  • Zucker, Stephen D (2002). All kidding aside with the use of lamivudine in children with chronic hepatitis B. . Gastroenterology , 123 (5) , 1741-3; discussion 1.
  • Zucker, Stephen D (2002). Some TIPS for the prevention of recurrent variceal hemorrhage? . Gastroenterology , 123 (1) , 384-6; discussion 38.
  • Zucker, Stephen D (2002). Whomsoever ignores the natural history of the hepatitis C virus is doomed to treat it. . Gastroenterology , 122 (2) , 578-9.
  • Weisiger, R. A., & Zucker, S. D. (2002). Transfer of fatty acids between intracellular membranes: roles of soluble binding proteins, distance, and time. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 282 (1) , G105-15.
  • Zucker,S.D. (2001). A potential new hepatitis agent: making sen-se of the data . Gastroenterology , 121 (3) , 734 , 735.
  • Pilla, J., & Zucker, S. (2001). Cesarean for c? possibly.. . Gastroenterology , 120 (6) , 1555 , 1557.
  • Zucker,S.D. (2001). Kinetic model of protein-mediated ligand transport: influence of soluble binding proteins on the intermembrane diffusion of a fluorescent fatty acid . Biochemistry , 40 (4) , 977 , 986.
  • Zucker, S., Goessling, W., Bootle, E., & Sterritt, C. (2001). Localization of bilirubin in phospholipid bilayers by parallax analysis of fluorescence quenching . Journal of Lipid Research , 42 (9) , 1377 , 1388.
  • Zucker,S.D. (2001). Management of refractory ascites: are tips or taps tops? . Gastroenterology , 120 (1) , 311 , 312.
  • Zucker, S., Qin, X., Rouster, S., Yu, F., Green, R., Keshavan, P., Feinberg, J., & Sherman, K. (2001). Mechanism of indinavir-induced hyperbilirubinemia . Proceedings of the National Academy of Sciences of the United States of America , 98 (22) , 12671 , 12676.
  • Zucker,S.D. (2001). The hepatitis b vaccine: sorting through the b.s. about m.s . Gastroenterology , 120 (7) , 1880 , 1882.
  • Zucker, S. D., Qin, X., Rouster, S. D., Yu, F., Green, R. M., Keshavan, P., Feinberg, J., & Sherman, K. E. (2001). Mechanism of indinavir-induced hyperbilirubinemia. . Proceedings of the National Academy of Sciences of the United States of America , 98 (22) , 12671-6.
  • Zucker, S D (2001). A potential new hepatitis agent: making SEN-se of the data. . Gastroenterology , 121 (3) , 734-5.
  • Zucker, S. D., Goessling, W., Bootle, E. J., & Sterritt, C. (2001). Localization of bilirubin in phospholipid bilayers by parallax analysis of fluorescence quenching. . Journal of Lipid Research , 42 (9) , 1377-88.
  • Zucker, S D (2001). The hepatitis B vaccine: sorting through the B.S. about M.S. . Gastroenterology , 120 (7) , 1880-2.
  • Pilla, J. A., & Zucker, S. D. (2001). Cesarean for C? Possibly... . Gastroenterology , 120 (6) , 1555-7.
  • Zucker, S D (2001). Kinetic model of protein-mediated ligand transport: influence of soluble binding proteins on the intermembrane diffusion of a fluorescent fatty acid. . Biochemistry , 40 (4) , 977-86.
  • Zucker, S D (2001). Management of refractory ascites: are tips or taps tops? . Gastroenterology , 120 (1) , 311-2.
  • Zucker,S.D. (2000). Diet and colon cancer: strike out the bran . Gastroenterology , 119 (2) , 590 , 591.
  • Zucker, S., & Goessling, W. (2000). Mechanism of hepatocellular uptake of albumin-bound bilirubin . Biochimica Et Biophysica Acta , 1463 (2) , 197 , 208.
  • Goessling, W., & Zucker, S. (2000). Role of apolipoprotein d in the transport of bilirubin in plasma . American Journal of Physiology.Gastrointestinal and Liver Physiology , 279 (2) , G356 , 65.
  • Goessling, W., & Zucker, S. D. (2000). Role of apolipoprotein D in the transport of bilirubin in plasma. . American Journal of Physiology. Gastrointestinal and Liver Physiology , 279 (2) , G356-65.
  • Zucker, (2000). Diet and colon cancer: strike out the bran . Gastroenterology , 119 (2) , 590-1.
  • Zucker, S. D., & Goessling, W. (2000). Mechanism of hepatocellular uptake of albumin-bound bilirubin. . Biochimica Et Biophysica Acta , 1463 (2) , 197-208.
  • Zucker, S., Goessling, W., & Hoppin, A. (1999). Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes . The Journal of Biological Chemistry , 274 (16) , 10852 , 10862.
  • Zucker, S. D., Goessling, W., & Hoppin, A. G. (1999). Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes. . The Journal of Biological Chemistry , 274 (16) , 10852-62.
  • Gollan, J., & Zucker, S. (1996). A new voyage of discovery: transport through the hepatocyte . Transactions of the American Clinical and Climatological Association , 107 , 48 , 55; discussion 55-6.
  • Albalak, A., Zeidel, M., Zucker, S., Jackson, A., & Donovan, J. (1996). Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes . Biochemistry , 35 (24) , 7936 , 7945.
  • Zucker, S., Goessling, W., & Gollan, J. (1996). Intracellular transport of small hydrophobic compounds by the hepatocyte . Seminars in Liver Disease , 16 (2) , 159 , 167.
  • Albalak, A., Zeidel, M. L., Zucker, S. D., Jackson, A. A., & Donovan, J. M. (1996). Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes. . Biochemistry , 35 (24) , 7936-45.
  • Zucker, S. D., Goessling, W., & Gollan, J. L. (1996). Intracellular transport of small hydrophobic compounds by the hepatocyte. . Seminars in Liver Disease , 16 (2) , 159-67.
  • Gollan, J. L., & Zucker, S. D. (1996). A new voyage of discovery: transport through the hepatocyte. . Transactions of the American Clinical and Climatological Association , 107 , 48-55; discussion 55.
  • Zucker, S., Goessling, W., Ransil, B., & Gollan, J. (1995). Influence of glutathione s-transferase b (ligandin) on the intermembrane transfer of bilirubin. implications for the intracellular transport of nonsubstrate ligands in hepatocytes . The Journal of Clinical Investigation , 96 (4) , 1927 , 1935.
  • Zucker, S., Goessling, W., & Gollan, J. (1995). Kinetics of bilirubin transfer between serum albumin and membrane vesicles. insight into the mechanism of organic anion delivery to the hepatocyte plasma membrane . The Journal of Biological Chemistry , 270 (3) , 1074 , 1081.
  • Zucker, S. D., Goessling, W., Ransil, B. J., & Gollan, J. L. (1995). Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin. Implications for the intracellular transport of nonsubstrate ligands in hepatocytes. . The Journal of Clinical Investigation , 96 (4) , 1927-35.
  • Zucker, S. D., Goessling, W., & Gollan, J. L. (1995). Kinetics of bilirubin transfer between serum albumin and membrane vesicles. Insight into the mechanism of organic anion delivery to the hepatocyte plasma membrane. . The Journal of Biological Chemistry , 270 (3) , 1074-81.
  • Zucker, S., Goessling, W., Zeidel, M., & Gollan, J. (1994). Membrane lipid composition and vesicle size modulate bilirubin intermembrane transfer. evidence for membrane-directed trafficking of bilirubin in the hepatocyte . The Journal of Biological Chemistry , 269 (30) , 19262 , 19270.
  • Zucker, S. D., Goessling, W., Zeidel, M. L., & Gollan, J. L. (1994). Membrane lipid composition and vesicle size modulate bilirubin intermembrane transfer. Evidence for membrane-directed trafficking of bilirubin in the hepatocyte. . The Journal of Biological Chemistry , 269 (30) , 19262-70.
  • Zucker, S., Storch, J., Zeidel, M., & Gollan, J. (1992). Mechanism of the spontaneous transfer of unconjugated bilirubin between small unilamellar phosphatidylcholine vesicles . Biochemistry , 31 (12) , 3184 , 3192.
  • Zucker, S. D., Storch, J., Zeidel, M. L., & Gollan, J. L. (1992). Mechanism of the spontaneous transfer of unconjugated bilirubin between small unilamellar phosphatidylcholine vesicles. . Biochemistry , 31 (12) , 3184-92.
  • Smith, D. L. H., Shire, N. J., Watts, N. B., Schmitter, T., Szabo, G., & Zucker, S. D. Hyperbilirubinemia is not a major contributing factor to altered bone mineral density in patients with chronic liver disease. . Journal of Clinical Densitometry : the Official Journal of the International Society For Clinical Densitometry , 9 (1) , 105-13.

Published Abstracts:

  • Zucker S, Connors P, Crawford J, Carr-Locke D (1991). Initial clinical experience with percutaneous liver biopsy using the Bard monopty™ instrument . Am J Gastroenterol. , 86 , 1343.
  • Zucker S, Narciso J, Zeidel M, Gollan J (1992). Dansyl-labeled taurocholate transfer between phospholipid vesicles: implications for the rapid hepatocellular transport of bile salts. . Gastroenterology , 102 , 914A.
  • Zucker SD, Narciso JP, Zeidel ML, Crawford JM, Gollan JL (1993). Aqueous transfer of dansyl-labeled taurocholate between phospholipid vesicles: implicatinos for intracellular transport of bile sales . Symposium on Bile Acids: 1993 and the Future 1993 , Abstract Booklet , 147.
  • Zucker SD, Narciso JP, Zeidel ML, Crawford JM, Gollan JL (1993). Aqueous tranfer of dansyl-labeled bile salts between phospholipid vesicles: effects of hydrophobicity on membrane interactions . Gastroenterology , 104 , A1025.
  • Cohen DE, Leonard MR, Zucker SD, Carey MC (1993). Modeling the rate limiting step in biliary phosphatidylcholine (PC) secretion: bile salts (BS) activate PC-transfer protein at the endoplasmic reticulum . Gastroenterology , 104 , A889.
  • Hoppin AG, Goessling W, Gollan JL and Zucker SD (1995). The role of lipoproteins and erythrocyte membranes in the transport of organic anions in blood . Gastroenterology , 108 , A1086.
  • Zucker SD, Hoppin AG (1996). Unconjugated bilirubin exhibits spontaneous transmembrane flip-flop . Hepatology , 24 , 132A.
  • Zucker SD, Bootle EJ (1996). Localization of bilirubin in lipid bilayers by fluorescence parallax analysis . Hepatology , 24 , 604A.
  • Goessling W, Zucker SD (1997). Hepatocellular uptake of bilirubin occurs via rapid transmembrane diffusion . Hepatology , 26 , 385A.
  • Goessling W, Zucker SD (1997). Human apolipoprotein D binds bilirubin with high affinity and facilitates bilirubin association with plasma HDL . Hepatology , 26 , 385A.
  • Goessling W, Zucker SD (06-1998). Bilirubin uptake by hepatocytes occurs via rapid transmembrane diffusion and does not require specific trnasport proteins . AASLD Basic Research Single Topic Conference.
  • Zucker SD, Qin X, Yu F, Goessling W (1999). Inhibition of breast cancer cell proliferation by unconjugated bilirubin is associated with enhanced expression of apolipoprotein D and increased nuclear translocation of transcriptiopn factor NF-ĸB . Hepatology , 30 , 498A.
  • Zucker SD, Qin X (1999). Effect of bovine serum albuin on the intermembrane diffusion of 12-anthroyloxy stearate: implications for the role of soluble proteins in the intracellular transport of hydrophobic ligands . Helpatology , 30 , 464A.
  • Zucker SD (07-2000). Effect of soluble binding proteins on the intermembrane diffusion of fluorescent fatty acids: influence of the mechanism of ligand-protein interaction . FASEB Summer Research Conference.
  • Zucker SD, Goessling W (2000). Bilirubin-membrane interactions: bilayer localization of unconjugated and taurine-conjugated bilirubin as determined by parallax analysis of fluorescence quenching . Hepatology , 32 , 427A.
  • Zucker SD, Qin X, Rouster SD, Yu F, Green RM, Feinberg J, Sherman KE (2001). Mechanism of indinavir-induced hyperbilirubinemia . Gastroenterology , 120 , A-45.
  • Wang W, Qin X, Yu F, Zucker SD (2002). Unconjugated bilirubin attenuates the inflammatory response through an NF-ĸB-dependent pathway . Gastroenterology , 122 , A636.
  • Keshavan P, Zucker SD (2002). Role of bilirubin in regulating colonic adenocarcinoma cell growth . Gastroenterology , 122 , A242.
  • Scheidler MD, Zucker SD (2002). Utility of cytomegalovirus (CMV) tissue culture and early antigen in the diagnosis of CMV hepatitis in liver transplant recipients . Hepatology , 36 , 661A.
  • Wang W, Chen H, Smith DL, Keshavan P, Rabbani LE, Zucker SD (2002). Adventitial delivery of unconjugated bilirubin is not p reventive against intimal hyperplasia in rat carotid arterial injury . Hepatology , 36 , 450A.
  • Harmon G, Osmer E, Zucker SD, Green RM (2002). Bilirubin potentiates gene expression of hepatic UDP-glucuronosyltransferase (UGT1A1) in H35 cells . Hepatology , 36 , 340A.
  • Keshavan P, Deem TL, Cook-Mills JM, Zucker SD (2003). Unconjugated bilirubin inhibits lymphocyte migration across endothelial monolayers . Gastroenterology , 124 , A-727.
  • Wang WW, Smith DLH, Zucker SD (2003). Bilirubin regulates iNOS expression and nitric oxide production in endotoxemia . Hepatology , 38 , 251A.
  • Keshavan P, Deem TL, Schwemberger SJ, Babcock GF, Cook-Mills JM, Zucker SD Unconjugated bilirubin inhibits VCAM-1 -mediated transendothelial leukocyte migration . Gastroenterology , 128 , A-216.
  • Smith DLH, Schmitter T, Shire N, Watts NB, Zucker SD (2005). Hyperbilirubinemia is not associated with altered bone mineral density in patients with end-stage liver disease and in Gunn rats . Gastroenterology , 128 , A-667.
  • Wadhwa A, Zucker SD, Coberly L (2005). Epstein-Barr Virus associated hemophagocytic lymphohistiocytosis in a 21 year old male . J Gen Intern Med , 20 (supp 11) , 241.
  • Avissar U, Keshavan P, Smith DLH, Zucker SD (2005). Effect of bile constituents on intestinal adenoma formation in Min mice . Hepatology , 42 , 459A.
  • Kindel TL, Keshavan P, Smith DL, Zucker SD (2008). Bilirubin suppresses intestinal inflammation in the DSS model of acute colitis in mice . Gastroenterology , 134 , A-260.
  • Smith DLH, Zucker SD (2008). Mechanism of bilirubin inhibition of iNOS up-regulation by lipopolysaccharide . Gastroenterology , 134 , A-771.
  • Barry CT, Avissar U, Asebrook M, Sostok M, Zucker SD (2008). Development of a standardized patient (SP) exercise to assess core competencies for hepatology training during fellowship . Hepatology , 48 , 793A , 794A.
  • Smith DLH, Ahmed K, Keshavan P, Avissar U, Zucker SD (2010). (In Press). Sodium taurocholate suppresses intestinal adenoma formation in APCMin/+ mice via a farnesoid X receptor (FXR)-dependent mechanism . Gastroenterology.
  • Smith DLH, Zucker SD (2010). (In Press). Bilirubin inhibits the up-regulation of inducible nitric oxide xynthase (iNOS) by suppressing Toll-like receptor 4 (TLR4)-dependent activation of NADPH oxidase (Nox) . Gastroenterology.

Book Chapter:

  • Zucker SD, Gollan JL (1992). Modern Concepts in Gastroenterology In Thompson ABR, DaCosta LR, Watson WC (Eds.) , Copper metabolism and Wilson's disease: an "ion" recent advances. (pp. 223 , 262). New York : Plenum Medical Book Company . Co-Author.
  • Zucker SD, Gollan JL (1992). Hepatobiliary Diseases In Prieto J, Rodes J, Shafritz DA (Eds.) , Wilson's disease: pathophysiology and therapy. (pp. 801 , 834). Barcelona : Springer-Verlag . Co-Author.
  • Zucker SD, Gollan JL (1993). Conn's Current Therapy In Rakel RE (Eds.) , Cirrhosis (pp. 447 , 457). Philadelphia : W.B. Saunders Company . Co-Author.
  • Zucker SD, Gollan JL (1994). Conn's Current Therapy In Rakel RE (Eds.) , Bleeding esophageal varices (pp. 450 , 456). Philadelphia : W.B. Saunders . Co-Author.
  • Zucker SD, Gollan JL (1994). Conn;s Current Therapy In Rakel RE (Eds.) , Cirrhosis (pp. 440 , 449). Philadelphia : W.B. Saunders Company . Co-Author.
  • Zucker SD, Gollan JL (1995). Bockus Gastroenterology, Fifth Edition In Haubrich WS, Schaffner F (Eds.) , Physiology of the liver. (pp. 1858 , 1905). Philadelphia : W.B. Saunders Company . Co-Author.
  • Zucker SD, Gollan JL (1996). Hepatology: A Textbook of Liver Disease, 3rd ed. In Zakim D, Boyer TD (Eds.) , Wilson's disease and hepatic copper toxicosis (pp. 1405 , 1438). Philadelphia : W.B. Saunders Company . Co-Author.
  • Gollan JL, Zucker SD (1996). Acute and Chronic Liver Diseases: Molecular Biology anc Clinics In Bianchi L, Schmid R (Eds.) , Wilson's disease: diagnosis, clinical course and therapy. (pp. 178 , 191). Lancaster : Kluwer Academic Publishers . Co-Author.
  • Saxena R, Zucker SD, Crawford JM (2003). Hepatology: A Textbook of Liver Disease, 4th ed. In Zakim D, Boyer TD (Eds.) , Anatomy and physiology of the liver. (pp. 3 , 30). Philadelphia : Saunders . Co-Author.
  • Wang WW, Zucker SD (2003). Encyclopedia of Gastroenterology In Johnson LR, (Eds.) , Bilirubin and jaundice (pp. 219 , 222). San Diego : Academic Press . Co-Author.
  • Duncan CW, Zucker SD (2008). Diseases and Disorders (vol. 2) In Cavendish M (Eds.) , Gallstone (pp. 368 , 369). London : Brown Reference Group . Co-Author.

    Research Grants:

  • NIH/NIDDK R01 . Anti-inflamatory Properties of Bilirubin, P.I.
  • NIH/NCI R21 . Role of Bilirubin in Colorectal Cancer Chemoprevention, P.I.
  • . University of Cincinnati Medical Education Res Project Development of Standardized Patient Exercises to Assess Clinical Core Compentencies in Fellowship Training, P.I.
  • NIH/NIDDK R21 . Anti-inflammatory Properties of Unconjugated Bilirubin, P.I.
  • . American Cancer Society Chemoprevention of Colorectal Cancer by Unconjugated Bilirubin, P.I.
  • . Cancer Research Foundation of America Use of Bilirubin for the Chemoprevention of Colorectal Cancer, P.I.
  • NIH/NIDDK RO1 . Regulation of Hepatic Lipid Metabolism by Organic Anions, P.I.
  • . Hood Foundation Basic Research Award. Bilirubin transport and toxicity in the neonate , P.I.
  • NIH/NIDDK . Pilot-Feasibility Grant. Role of lipid structures in hepatocellular transport, P.I.
  • NIH/NIDDK K11 . Physician Scientist Award. Hepatocellular transport of small hydrophobic compounds., P.I.
  • 1 R21 CA119006 National Cancer Institute. Role of Bilirubin in Colorectal Cancer Chemoprevention, PI, Closed.
  • R01 DK071125 National Inst of Diabetes and Digestive and Kidney Disease. Anti-Inflammatory Properties of Bilirubin, PI, Closed.
  • 5-R21-DK-063954-02-A0-S0-E0 National Inst of Diabetes and Digestive and Kidney Disease. Anti-Inflammatory Properties of Uncongugated Bilirubin, PI, Closed.
  • American Cancer Society - Ohio Chapter. Chemoprevention of Colorectal Cancer by Unconjugated Bilirubin, PI, Closed.
  • Cancer Research and Prevention Foundation. Use of Bilirubin for the Chemoprevention of Colorectal Cancer, PI, Closed.
  • Cancer Research and Prevention Foundation. Use of Bilirubin for the Chemoprevention of Colorectal Cancer, PI, Closed.
  • 5-R01-DK-51679-06-A0-S0-E0 National Inst of Diabetes and Digestive and Kidney Disease. Regulation of Hepatic Lipid Metabolism by Organic Anions, PI, Closed.
  • 3 R01 DK071125-03S1 National Inst of Diabetes and Digestive and Kidney Disease. Anti-Inflammatory Properties of Bilirubin, PI, Closed.

Recent Awards/Honors:

  • Stanley Adamson Prize in Chemistry, Swarthmore College, 1980
  • Student Medalist to the American Society of Chemists, 1981
  • B.A. in Biochemistry with Distinction, Swarthmore College, 1981
  • Phi Beta Kappa, Swarthmore College, 1981
  • Sigma Xi Scientific Research Society, Swarthmore College, 1981
  • American Gastroenterological Association Senior Fellow Award, 1991
  • American Association for the Study of Liver Diseases Trainee Travel Award, 1991
  • Glaxo Research Institute Fellows Award, 1991
  • Jerry S. Trier Award for Clinical Teaching in Gastroenterology. Brigham and Women's Hospital, 1998
  • The Ralph A. Giannella Award for Excellence in Clinical Teaching in Gastroenterology. University of Cincinnati, 2003
  • The Ralph A. Giannella Award for Excellence in Clinical Teaching in Gastroenterology. University of Cincinnati, 2006
  • Elected to Best Doctors in America , 2008,2009
  • Elected to Best Doctors in America , 2009,2010
CARE/Crawley Building

More Information


For more information on the UC Department of Internal Medicine, please contact us at:

UC Department of Internal Medicine
231 Albert Sabin Way
Medical Sciences Building Room 6065
PO Box 670557
Cincinnati, OH 45267-0557

Phone: 513-558-4231
Fax: 513-558-0852
Email: ucintmed@uc.edu