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Conforti, Laura PhD
Division: Nephrology & Hypertension
Title: Associate Professor
Education: 1987, PhD School of Specialization in Pharmacological Research, Regione Lombardia, Mario Negri Institute for Pharmacological Research, Milano, Italy. 1986, Dr. In Pharmacy. School of Pharmacy, University of Genova, Italy.
Training: 1985, Certified Pharmacist, University of Genova, Italy. 1984, Chemistry & Pharmaceutical Technology. School of Chemistry & Pharmaceutical Technology, University of Genova, Italy.
Clinical Interests:
Research Interests: Dr. Conforti's laboratory is interested in ion channels and membrane mechanisms regulating the function of human T lymphocytes. A current major interest in this laboratory is to study how ion channels contribute to T cell response and adaptation to changes in the microenvironment, especially to altered oxygen levels. Another major research interest of this laboratory is in the role that ion channel play in the activation process of human T cells in health and pathological conditions such as autoimmune diseases. Various techniques are used to perform these studies e.g. patch-clamping, molecular biology, and imaging among others.
Recent Publications:
Robbins J.R., Lee S.M. , Filipovich A.H., Neumeier L., Szigligeti P., Petrovic M. and Conforti L. Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels. J. Physiol, 564.1: 131-143, 2005.
Conforti L., Petrovic M., Mohammad D., Lee S., Ma Q., Barone S. and Filipovich A. H.: Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation. J. Immunol. 170: 695-702, 2003.
Conforti L., Takimoto K., Petrovic M., Pongs O. and Millhorn D.E.: The pore region of the Kv1.2a subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity. Biochem. Biophys. Res. Comm. 306: 450-456, 2003.
Takimoto K., Yang E-K and Conforti L. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. J. Biol. Chem. 277(30):26904-11, 2002.
Conforti L. and Sperelakis N.: The patch-clamp technique for measurement of K+ channels in Xenopus oocytes and mammalian expression systems. In: Potassium channels in cardiovascular biology. Kluwer-Plenum Press, S. L. Archer and N. J. Rusch. (eds), pg. 143-161, 2001.
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Email: conforl@ucmail.uc.edu
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