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Ridgway, William MD
Division: Immunology, Allergy & Rheumatology
Title: Director, Division of Immunology
Education: MD - University of Rochester, NY
Training: Residency: Stanford University School of Medicine
Fellowship: Rheumatology/Immunology, Stanford University Hospital, CA Howard Hughes Medical Institute
Post-doc: Stanford University School of Medicine
Clinical Interests: Rheumatology
Research Interests: My major areas of investigative interest are autoimmunity, immunogenetics, T cells, autoimmune (type I) diabetes, autoimmune liver disease (primary biliary cirrhosis), and relapsing polychondritis. I am a Principal Investigator on two N.I.H. grants, The Pathogenesis of Autoimmunity in a Murine Model of Primary Biliary Cirrhosis and "Immunogenetic Control of NOD CD4+ T cell Tolerance". Our goal is to determine the immunogenetic mechanisms of autoimmune biliary disease, type one diabetes, and relapsing polychondritis arising in nonobese diabetic (NOD) and NOD congenic mice.
Recent Publications:
Junichiro Irie, Brian Reck, Yuehong Wu, Linda S. Wicker, Sarah Howlett, Daniel Rainbow, Eleanor Feingold and William M. Ridgway. Genome wide microarray expression analysis of CD4+ T cells from NOD congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes. The Journal of Immunology, Jan 15;180(2):1071-9. (2008)
Junichiro Irie, Yuehong Wu, Kritika Kachapati, Robert S. Mittler, and William M. Ridgway, Modulating Protective and Pathogenic CD4+ Subsets via CD137 in type one diabetes, Diabetes, 56(1): 186-96 (2007)
Junichiro Irie, Yuehong Wu, Linda S. Wicker, Daniel Rainbow, Michael K. Nalesnik, Raphael Hirsch, Larry Peterson, Patrick S.C. Leung, Chunmei Cheng, Ian Mackay , M. Eric Gershwin, and William M. Ridgway, NOD.c3c4 Congenic Mice Develop Autoimmune Biliary Disease that Serologically and Pathogenetically Models Human Primary Biliary Cirrhosis, The Journal of Experimental Medicine, 203(5):1209-1219 (2006)
Junichiro Irie, Yuehong WU, David A. Sass and William M. Ridgway, Genetic control of anti-Sm antibody production in NOD congenic mice narrowed to the Idd9.3 region. Immunogenetics, p.1-6, Jan, (2006).
Syuichi Koarada, Yuehong Wu, Noreen Fertig, Michael Nalesnik, John A. Todd, Paul A. Lyons, Judith Fenyk-Melody, Linda S. Wicker, Laurence B. Peterson, and William M. Ridgway, Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a non-obese diabetic (NOD) congenic strain. The Journal of Immunology, 173: 2315-2323 (2004)
Notes:
Email: william.ridgway@uc.edu
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