Overview and Objectives Clinical and Educational Activities Research Current Trainees Faculty Benefits Career Paths of Recent Graduates Contact Information and How to Apply

OVERVIEW AND OBJECTIVES
The goal of the Fellowship program in Infectious Diseases at the University of Cincinnati is to train physicians to become outstanding clinicians or clinician-investigators in infectious diseases. To achieve that goal, we provide physicians who have completed their residencies in internal medicine with two years of subspecialty training that is divided between instruction in clinical infectious diseases and research. For those interested in pursuing a career in academic medicine, we strongly recommend a three-year program. We believe that the infectious diseases specialist should be well schooled in research methodologies. The fellowship includes training in all clinical aspects of infectious diseases, infection control, diagnostic microbiology (bacteriology, virology, mycology, and parasitology) and clinical or basic laboratory research. At the completion of the fellowship, all participants in the program who have passed the Internal Medicine Boards are qualified for the subspecialty examination in Infectious Diseases administered by the American Board of Internal Medicine.

CLINICAL AND EDUCATIONAL ACTIVITIES

Clinical Experience
To develop a high level of clinical expertise, fellows spend up to twelve months of the first two years on an intensive infectious diseases consultation service. Under the supervision of faculty members, fellows serve as consultants within the Medical Center. They supervise and teach medical residents and fourth-year medical students who are assigned to the infectious diseases elective. Outpatient experience is obtained in the Infectious Diseases Center at University Hospital and in the Veterans Affairs Medical Center Infectious Diseases Clinic. Both are operated by the Division of Infectious Diseases. Clinic time averages one half-day per week for two years.

The Infectious Diseases faculty provides consultation to University Hospital and Veterans Affairs Medical Center. The fellows participate in this consultation activity to experience the clinical spectrum of infectious diseases. Furthermore, fellows rotate through the STD Clinic of the city of Cincinnati, the Blood and Marrow Unit of Jewish Hospital and the TB Control Clinic of Hamilton County Public Health. These rotations will provide experience in a broad range of infectious diseases.

One of the critical areas of any infectious diseases program is infection control. At the University of Cincinnati, infectious diseases fellows spend at least one month in the Infection Control programs at both The University Hospital and the VAMC. Under the direction of the Infection Control staff, fellows are assigned a problem and learn how to gather necessary information and resolve specific issues.

Diagnostic Laboratory Experience
Fellows receive practical training in the diagnostic laboratories including bacteriology, antimicrobial susceptibility testing, determination of serum antibiotic concentrations, mycology, virology, immunology, serology and parasitology.

Conferences and Educational Opportunities
An infectious diseases clinical conference and a journal club are held weekly. A formal research conference is held monthly. Combined Infectious Diseases Rounds is a monthly clinical conference attended by University of Cincinnati and Cincinnati Children's Hospital Medical Center. The Infectious Diseases Division presents Medical Grand Rounds at University Hospital five times a year. Throughout the fellowship, fellows have the opportunity to take tuition-free graduate courses given by the Department of Molecular Genetics, Biochemistry, and Microbiology (e.g. microbial physiology, medical microbiology, virology, molecular genetics, immunology and cell biology).

Fellows are given a travel allowance to attend one meeting per year after discussion with the director of the program.

RESEARCH

Research Experience
Infectious diseases fellows are actively involved in research projects. During the fellowship, eight months are available for required research. Fellow projects depend on previous experience, research interests and projects that are in progress in the laboratories of the faculty members. Fellows rotate through all of the laboratories during a separate research orientation month early in their fellowship, so that they can make informed decisions about their research efforts.

Research Activities
The Division of Infectious Diseases at the University of Cincinnati College of Medicine has a wide range of research activities in which fellows can participate. Whether your interest is clinical investigation, cellular immunology or molecular microbiology, there are faculty members actively involved in ongoing research in these areas. Currently, there is NIH-funded research in immunology, mycology, and host-pathogen interaction. The major research programs in the division are concerned with medical mycology, opportunistic infections and clinical management of AIDS.

Laboratory Investigation
The University of Cincinnati College of Medicine has a long tradition of excellence in the pathological and clinical aspects of fungal diseases. The geographic location of Cincinnati places it directly in an endemic region for Histoplasma capsulatum and Blastomyces dermatitidis. Since 1980, there has been a concerted effort to develop a core of investigators dedicated to basic and clinical research in medical mycology. This team consists of investigators with primary appointments in three departments: The Department of Medicine, the Department of Pathology, and the Department of Molecular Genetics, Biochemistry and Microbiology. The current projects include:

1) Analysis of the immunogenic determinants from H. capsulatum that activate murine and human T-cell clones. Analysis of T-cell receptor repertoire among Histoplasma-specific T-cells. Studies of cytokine-mediated immunity to H. capsulatum. Examination of apoptosis as a host defense mechanism to H. capsulatum

2) Studies of the interaction between human phagocytes and H. capsulatum yeast and microconidia including characterization of modulators of phagolysosomal conditions involved in yeast inhibition and killing

3) Sequencing the genome of P. carinii and genetic profiling of the organism in response to antimicrobial agents; understanding the signaling mechanisms associated with attachment

4) Analysis of the epidemiology of P. carinii infections in animals and transmission of P. carinii species and strains. Molecular characterization of species and strains of P. carinii. In vitro cultivation of P. carinii and drug susceptibility testing of P. carinii

5) Studies examining aspects of human P. carinii infection including epidemiology, development of in-vitro assays of viability and drug susceptibility, cell-mediated and humoral-immune responses

6) Studies of the pathogenesis of Aspergillus species

7) Studies of population genetics of HIV

Clinical Investigation
The University of Cincinnati is a regional referral center for patients with HIV infections. An active clinical and basic research program related to HIV infection and complicating opportunistic infection is based within the Division of Infectious Diseases. There also is a program to study human papilloma virus in HIV-infected individuals.

We are active participants in the AIDS Clinical Trials Group (ACTG) of the National Institute of Allergy and Infectious Diseases. Members of the faculty are engaged in studies of hyperlipidemia and cardiovascular events in AIDS patients. In addition to ACTG-sponsored clinical trials, the program participates actively in pharmaceutical studies. The Infectious Diseases Center of University Hospital, a multidisciplinary clinic for HIV and general ID, facilitates these research endeavors.

Interdepartmental cooperation allows opportunities for interaction with faculty within the Department of Molecular Genetics, Biochemistry, and Microbiology, Pathology, and other divisions within the Department of Medicine. Allied research interests include basic and clinical immunology, molecular microbiology, and health-outcomes research.

CURRENT TRAINEES

Name	Residency	Medical School	Years in Program
Bobula, Steven	University of Cincinnati, Cincinnati, OH	Wright State University School of Medicine, Dayton, OH	2008-2010
Devarajan, Vidya	New York Hospital, Cornell Medical Center, New York, NY	State University of New York Stony Brook School of Medicine, Stony Brook, NY	2008-2010
Ameneni, Shashikala	Rosalind Franklin University of Medicine and Science (formerly Chicago Medical School/Finch University) North Chicago, IL	Sri Devaraj Urs Medical College, India	2009-2011
Williams, Susana	University of Utah Medical Center, Salt Lake City, Utah	Meharry Medical College, Nashville, TN	2009-2011

FACULTY

Name	Position
Britigan, Bradley - MD	Taylor Professor, Chairman Department of Internal Medicine
Cushion, Melanie - PhD	Professor, Associate Chair for Research
Deepe, George - MD	Russell Morgan Professor of Medicine, Division Director
Feinberg, Judith - MD	Professor, Associate Chair of Medicine for Faculty Development
Fichtenbaum, Carl - MD	Professor, Associate Program Director, Internal MedicineResidency, Director Residency Research, Director, AIDS Clinical Trials Unit.
Forrester, Jennifer, MD	Assistant Professor of Clinical Medicine
Gomez, Francisco - MD	Assistant Professor
Grubbs, Peter - MD	Assistant Professor, Director, Infectious Diseases Center
Haglund, Lisa - MD	Associate Professor, Fellowship Program Director, Medical Director Hamilton County Tuberculosis Control
Kaul, Pamposh - MD	Assistant Professor, Clinical Director, AIDS Education Training Center
Kralovic, Stephen - MD	Associate Professor, Division of Infectious Diseases and Assistant Professor, Division of Epidemiology and Biostatistics
Newman, Simon - PhD	Professor
Robertson, Jaime - MD	Assistant Professor of Clinical Medicine
Roselle, Gary - MD	Professor, Chief, Medical Service, Veterans Affairs Medical Center, Associate Director, Department of Internal Medicine
Smulian, George - MD	Associate Professor, Associate Director, Division of Infectious Diseases, Chief, Infectious Diseases, Veterans Affairs Medical Center
Walzer, Peter - MD	Professor, Associate Chief of Staff for Research , Veterans Affairs Medical Center
Winters, Michael - MD	Research Assistant Professor

BENEFITS
You may find benefit information on the web site for the Health Alliance Office of Graduate Medical Education at www.med.uc.edu/residency.

CAREER PATHS OF RECENT GRADUATES

NAME	YEARS IN PROG	RESIDENCY	MEDICAL SCHOOL	POSITION AFTER FELLOWSHIP
Forrester, Jennifer	2007-2009	University of Cincinnati, Cincinnati, OH	University of Cincinnati, Cincinnati, OH	Assistant Professor, University of Cincinnati, Cincinnati, OH
Hebbeler-Clark, Renee	2007-2009	American University of the Caribbean, Netherlands Antilles	NEOUCOM/CMEF Northeastern Ohio University College of Medicine, Canton, OH	Critical Care Fellowship, University of Pittsburgh
De Perio, Marie	2006-2008	McGaw Medical Center, Northwestern University, Chicago, IL	Georgetown University Washington, DC	Fellow in Epidemic Intelligence Service, Centers for Diseases Control & Prevention, Atlanta, GA/Cincinnati, OH
Sharma, Sonia, MD	2005-2007	University of Cincinnati Cincinnati, OH, University of Wisconsin Milwaukee, WI	Saba University, Netherlands Antilles	Private Practice, Racin, WI
Cummins, Nathan, MD	2005-2007	University of Cincinnati Cincinnati, OH	University of Kentucky Lexington, KY	Fellow in Transplant Infectious Diseases at Mayo Clinic, Rochester, MN
Jaime Robertson, MD	2004-2006	University of Cincinnati, Cincinnati, OH	University of Oklahoma, Oklahoma City, OK	Assistant Professor, University of Cincinnati, Cincinnati, OH

CONTACT INFORMATION AND HOW TO APPLY
Jane Buchanan at Jane.Buchanan@uc.edu
Lisa Haglund, MD at Lisa.Haglund@uc.edu

The University of Cincinnati Department of Internal Medicine, Division of Infectious Diseases, accepts applications only through the Electronic Residency Application Service(ERAS)

Applications are accepted through ERAS as early as September. We begin reviewing applications in December and contacting selected applicants to schedule interview dates beginning January through April.

Additional information may be obtained at http://www.med.uc.edu/residency - Choose Prospective Residents & Fellows.