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Newman, Simon PhD
Division: Infectious Diseases
Title: Professor
Education: PhD in Microbiology and Immunology, University of Alabama Medical Center, Birmingham, Alabama; MS in Cell and Molecular Biology, University of Alabama, University Station, Alabama; BA in Biology, Emory University, Atlanta, Georgia
Training: Postdoctoral training with Dr. Peter Henson, National Jewish Medical and Research Center, Denver, CO, and Dr. Gordon Ross, Univ. of North Carolina, Chapel Hill, NC
Clinical Interests:
Research Interests: The broad focus of research in my laboratory concerns the role of human neutrophils, monocyte/macrophages and dendritic cells in host defense against medically important fungal pathogens, including Histoplasma capsulatum, Candida albicans, Blastomyces dermatitidis, and Cryptococcus neoformans. Current projects are directed to: 1), define the role of extracellular matrix (EM) proteins and cytokines in activating macrophage anti-Histoplasma activity; and 2), to define the interactions between dendritic cells and fungi as to their phagocytic capacity and ability to present fungal antigens to T cells, and the regulation of this interaction by co-stimulatory molecules and cytokines.
Recent Publications:
Gomez FJ, R Pilcher-Roberts, A Alborzi, and SL Newman. Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5. J. Immunol. 2008; 181:7106-7114.
Hilty J, AG Smulian, and SL Newman. The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages, and for virulence in a murine model of histoplasmosis. Molecular Microbiology. 2008; 70: 127-139.
Newman SL, L Gootee, J Hilty, and RE Morris. Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. J. Immunol. 2006; 176:1806-1813.
Newman SL, B Bhugra, A Holly, and RE Morris. Enhanced killing of Candida albicans by human macrophages adherent to type 1 collagen matrices via induction of phagolysosomal fusion. Infect. Immun. 2005; 73:770-777.
Gildea LA, RE Morris, and SL Newman. Human dendritic cells kill and degrade Histoplasma capsulatum yeasts via phagolysosomal fusion. Infect. Immun. 2005; 73:6803-6811.
Notes: Dr. Newman is a well-established investigator in macrophage function and has recently gained recognition for his expertise in studies of host defenses against fungi. His specific research interests involve analysis of the interaction of H. capsulatum yeasts and conidia with human monocytes, macrophages, neutrophils and dendritic cells. He is a past Associate Editor of The Journal of Immunology and an Editorial Board member of Infection and Immunity. He also is an ad hoc reviewer for The Journal of Experimental Medicine, The Journal of Clinical Investigation, Proceedings of the National Academy of Sciences, USA, The Journal of Infectious Diseases, Medical Mycology, The American Journal of Pathology, American Review of Respiratory Disease, Arthritis and Rheumatism, The American Journal of Medical Sciences, Journal of Laboratory and Clinical Medicine, Kidney International, Natural Immunity and Blood. His published works include approximately 50 articles and approximately 60 abstracts.
Email: Simon.Newman@uc.edu
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