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Chatterjee, Sunil PhD
Division: Hematology & Oncology
Title: Professor of Medicine
Education: BS, Chemistry
Presidency College
Calcutta, India
MS, Biochemistry
University College of Science
Calcutta, India
PhD, Biochemistry
University College of Science
Calcutta, India
Training: PhD Thesis. University of Calcutta, Calcutta, India.
Protein biosynthesis in plant mitochondria.
Post-doctoral Fellow, Department of Microbiology University of Pennsylvania, Philadelphia.
Mechanism of peptide synthesis and the role of initiation factors in the process.
Clinical Interests: Dr. Chatterjee is a laboratory researcher.
Research Interests: Immuno/gene therapy is a promising approach for the management of malignancies. It is particularly useful for tumors that do not respond to or are resistant to conventional chemotherapy. The success of immuno/gene therapy depends on the ability of this approach to break tolerance of the host to the tumor. Tumors evade the hosts immune machinery by creating a microenvironment, which causes immune suppression. Our goal for the immuno/gene therapy is to create an inflammatory milieu designed to trigger a robust anti-tumor immune response. We designed a number of recombinant vaccinia viruses capable of creating an immune modulatory microenvironment at the tumor site. We are testing these constructs for their efficacy for invoking tumor specific immunity using suitable animal tumor models.
Recent Publications:
Dasgupta, S., Bhattacharya-Chatterjee, M., OMalley, Jr., B. W. and Chatterjee, S.K. Vaccination with Recombinant Vaccinia Virus Expressing Interleukin-2 Invokes Anti-tumor Cellular Immunity in An Orthotopic Murine Model of Head and Neck Squamous Cell Carcinoma. Molecular Therapy, 13: 183-193, 2005.
Dasgupta, S., Bhattacharya-Chatterjee, M., OMalley, Jr., B. W. and Chatterjee, S.K. Reversal of Immune Suppression Following Vaccination With Recombinant Vaccinia Virus Expressing IL-2 In An Orthotopic Murine Model of Head and Neck Squamous Cell Carcinoma. Cancer Therapy. 2:375-388, 2004.
Dasgupta, S., Bhattacharya-Chatterjee, M., OMalley, Jr., B. W. and Chatterjee, S.K. Inhibition of NK Cell Activity Through TGF-²1 By Down Regulation of NKG2D In A Murine Model of Head and Neck Cancer. J. Immunology 175: 5541-5550, 2005.
Dasgupta, S., Bhattacharya-Chatterjee, M, OMalley, B. W. Jr., and Chatterjee, S. K. Tumor Metastasis in An Orthotopic Murine Model of Head and Neck Cancer: Possible Role of TGF-beta 1 Secreted by the Tumor Cells. J. Cell. Biochem. 97: 1036-1051, 2006.
Dasgupta, S., Tripathi, P.K., Qin, H-X, Bhattacharya-Chatterjee, M., Valentino, J. and Chatterjee, S.K. Identification of Molecular Targets for Immunotherapy of Patients with Head and Neck Squamous Cell Carcinoma. Oral. Oncol. 42: 306-316, 2006.
Notes: Dr. Chatterjee has published extensively in the forms of manuscripts, abstracts, and book chapters and holds three patents. He has lectured extensively both nationally and internationally and has received many recognition awards. Over the years, he has trained several graduate students and post-doctoral fellows. Dr. Chatterjee is a member of the American Association for Advancement of Science, American Association for Cancer Research, New York Academy of Sciences, International Union Against Cancer (UICC Roll of Honour). He was a member of the Clinical Immunology: Biological Therapy Section of the IMMUNOLOGY/PRECLINICAL AND CLINICAL Subcommittee in 1999 and holds memberships in the American Association for Cancer Research and American Society of Gene Therapy. He is a grant reviewer and is an Ad Hoc grant reviewer for several scientific journals.
Email: chattesk@ucmail.uc.edu
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